WormBase Tree Display for Gene: WBGene00004735
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| WBGene00004735 | Evidence | Paper_evidence | WBPaper00005707 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y47D3B | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | sbp-1 | Person_evidence | WBPerson1122 | |||||
| Sequence_name | Y47D3B.7 | ||||||||
| Molecular_name | Y47D3B.7 | ||||||||
| Y47D3B.7.1 | |||||||||
| CE19180 | |||||||||
| Other_name | lpd-1 | Person_evidence | WBPerson346 | ||||||
| hlh-20 | CGC_data_submission | ||||||||
| SREBP | Paper_evidence | WBPaper00045855 | |||||||
| CELE_Y47D3B.7 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | sbp-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sbp | ||||||||
| Allele (221) | |||||||||
| Strain | WBStrain00036945 | ||||||||
| WBStrain00004778 | |||||||||
| WBStrain00004779 | |||||||||
| WBStrain00004781 | |||||||||
| WBStrain00030028 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Ortholog (39) | |||||||||
| Structured_description | Concise_description | sbp-1 encodes a basic helix-loop-helix (bHLH) transcription factor homologous to the mammalian Sterol Regulatory Element Binding Proteins (SREBPs, OMIM:184756, overexpression of nuclear form of SREBP-1c is associated with insulin resistance and features of congenital generalized lipodystrophy); in C. elegans, SBP-1 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for embryonic and larval development; in addition, sbp-1 is required for mediating the lipid accumulation and increased body width/length ratio that occurs in response to oxygen deprivation; sbp-1 expression is detected in the intestine, the major site of fat storage, from early embryogenesis through adulthood and also in the amphid neurons. | Paper_evidence | WBPaper00004403 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00005655 | |||||||||
| WBPaper00005707 | |||||||||
| WBPaper00024532 | |||||||||
| WBPaper00032534 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 22 May 2009 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor activity. Involved in several processes, including cellular response to zinc ion; fatty acid metabolic process; and positive regulation of macromolecule biosynthetic process. Located in nucleus. Expressed in several structures, including amphid neurons; head; intestine; and neurons. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including carotid artery disease; diabetes mellitus (multiple); and vascular dementia. Is an ortholog of human SREBF2 (sterol regulatory element binding transcription factor 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00041098 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Jun 2019 00:00:00 | ||||||||
| Potential_model | DOID:3407 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11290) | |||||
| DOID:0014667 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11289) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11289,HGNC:11290) | ||||||
| EFO:MONDO:0100212 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11289) | ||||||
| DOID:9744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11290) | ||||||
| DOID:1115 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11290) | ||||||
| DOID:8725 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11290) | ||||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11290) | ||||||
| DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11289,HGNC:11290) | ||||||
| Models_disease_asserted | WBDOannot00000695 | ||||||||
| Molecular_info | Corresponding_CDS | Y47D3B.7 | |||||||
| Corresponding_transcript | Y47D3B.7.1 | ||||||||
| Other_sequence | MC03533 | ||||||||
| CBC08829_1 | |||||||||
| Dviv_isotig09356 | |||||||||
| Dviv_isotig09354 | |||||||||
| CJC03389_1 | |||||||||
| JI165440.1 | |||||||||
| Associated_feature | WBsf717112 | ||||||||
| WBsf978916 | |||||||||
| WBsf994378 | |||||||||
| WBsf1015997 | |||||||||
| WBsf227574 | |||||||||
| Transcription_factor | WBTranscriptionFactor000200 | ||||||||
| Experimental_info | RNAi_result (106) | ||||||||
| Expr_pattern | Expr2348 | ||||||||
| Expr3071 | |||||||||
| Expr15552 | |||||||||
| Expr15752 | |||||||||
| Expr1026810 | |||||||||
| Expr1032335 | |||||||||
| Expr1160230 | |||||||||
| Expr1200022 | |||||||||
| Expr2015611 | |||||||||
| Expr2033846 | |||||||||
| Drives_construct | WBCnstr00010783 | ||||||||
| WBCnstr00011113 | |||||||||
| WBCnstr00015916 | |||||||||
| WBCnstr00022267 | |||||||||
| WBCnstr00035422 | |||||||||
| WBCnstr00042397 | |||||||||
| Construct_product | WBCnstr00010783 | ||||||||
| WBCnstr00016899 | |||||||||
| WBCnstr00022267 | |||||||||
| WBCnstr00035422 | |||||||||
| WBCnstr00042397 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (115) | |||||||||
| Interaction (99) | |||||||||
| WBProcess | WBbiopr:00000121 | ||||||||
| Map_info | Map | III | Position | 9.54307 | Error | 0.106683 | |||
| Positive | Positive_clone | H10N23 | |||||||
| Y47D3B | Inferred_automatically | From CDS info | |||||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (109) | |||||||||
| Picture | WBPicture0000013096 | ||||||||
| WBPicture0000013098 | |||||||||
| Remark | We were given the connection to sequence H10N23 in 1999. This sequence has been replaced by Y66A7A which has not been annotated. sdm 11/00 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
