WormBase Tree Display for Gene: WBGene00004414

WBGene00004414 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 1
    Name: CGC_name: rpl-3
      Sequence_name: F13B10.2
      Molecular_name (11)
      Other_name: CELE_F13B10.2 Accession_evidence: NDB BX284603
      Public_name: rpl-3
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rpl
    Allele (27)
    Legacy_information: Orthologous to yeast (S.cerevisiae) ribosomal protein rpl3 using blastP
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (45)
    Structured_description: Concise_description: rpl-3 encodes a large ribosomal subunit L3 protein required in mass RNAi assays for embryonic and larval viability, fertility, and general health; the rpl-3 transcription unit has a nonsense transcript that is up-regulated in vivo by smg[-] mutations, indicating that rpl-3 is a natural substrate for SMG-mediated nonsense suppresssion; several other natural mRNA substrates of SMG suppression (e.g., rpl-7, rpl-10, rpl-12) have protein products that are involved in translation. Paper_evidence: WBPaper00004313
            WBPaper00004403
            WBPaper00004651
            WBPaper00005654
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in cytoplasm and ribosome. Predicted to be part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2D. Is an ortholog of human RPL3 (ribosomal protein L3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0081160 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10351)
  Molecular_info: Corresponding_CDS: F13B10.2a
      F13B10.2c
      F13B10.2d
    Corresponding_transcript: F13B10.2b
      F13B10.2a.1
      F13B10.2a.2
      F13B10.2c.1
      F13B10.2d.1
    Other_sequence (421)
    Associated_feature (15)
  Experimental_info: RNAi_result (22)
    Expr_pattern: Expr1021197
      Expr1032218
      Expr1148423
      Expr2015473
      Expr2033708
    Drives_construct: WBCnstr00035504
    Construct_product: WBCnstr00035504
    Microarray_results (33)
    Expression_cluster: WBPaper00024704:Soluble_protein
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00035211:age-1_vs_age-1_upregulated
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00038357:atx-3_regulated_heat-shock
      WBPaper00039873:multi-aminoacyl-tRNA-synthetase-complex
      WBPaper00040209:B.thuringiensis_downregulated_N2
      WBPaper00040209:B.thuringiensis_upregulated_MY15
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040446:insoluble_protein
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042552:daf-2(e1370)_downregulated_daf-16-dependent
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044034:LEC-1_associated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045971:tunicamycin_upregulated_RtcB(null)
      WBPaper00046303:P.aeruginosa_upregulated_protein
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050412:cco-1(RNAi)_downregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050636:aging_regulated_insoluble_protein
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051558:aging_regulated
      WBPaper00051558:fog-2(q71)_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053039:Aspirin_upregulated
      WBPaper00053289:DREAM-target
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00055013:HMG-3_interacting_transcript
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:SGP_biased
      WBPaper00056900:ERH-2_interacting
      WBPaper00056900:PID-3_interacting
      WBPaper00056900:TOFU-6_interacting
      WBPaper00056900:TOST-1_interacting
      WBPaper00056997:nmad-1(ok3133)_downregulated_germline_25C
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00059194:KLF-1_interacting
      WBPaper00059254:CSR-1_interacting
      WBPaper00059254:PRG-1_interacting
      WBPaper00059254:WAGO-1_interacting
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-infection_12h_regulated
      WBPaper00060908:TEBP-1_interacting
      WBPaper00060908:TEBP-2_interacting
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061285:wounding_0h_upregulated
      WBPaper00061340:Excretory_cell
      WBPaper00061340:M_cell
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061377:PAN-1_interacting
      WBPaper00061393:C.albicans_regulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:rps-14_21270-rps-11_20714
      WBPaper00061651:CAN_enriched
      WBPaper00061651:Distal_tip_cell_enriched
      WBPaper00061651:Excretory_gland_cell_enriched
      WBPaper00061651:Germline_enriched
      WBPaper00061651:I4_enriched
      WBPaper00061651:M2_enriched
      WBPaper00061651:MC_enriched
      WBPaper00061651:MI_enriched
      WBPaper00061651:RIG_enriched
      WBPaper00061651:Spermatheca_enriched
      WBPaper00061818:AFD_enriched_protein
      WBPaper00061818:ELKS-1_interacting
      WBPaper00062002:Day4-adult_secretome
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064201:SNA-3_interacting
      WBPaper00064257:UNG-1_interacting
      WBPaper00064933:E.coli-binding_secret_protein
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065392:Lb.plantarum_downregulated
      WBPaper00065392:P.pentosaceus_downregulated
      WBPaper00065623:27
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00066085:hda-3(ok1991)_downregulated
      WBPaper00066085:sin-3(syb2172)_downregulated
      cgc4489_group_3
      WBPaper00005124:estrogen_10-5M_regulated
      WBPaper00005124:progesterone_10-7M_regulated
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025032:cluster_2
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00036286:Pattern_E
      WBPaper00039835:ifg-1_downregulated
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
    Interaction (375)
  Map_info: Map: III Position: -4.2473 Error: 0.000149
    Positive: Positive_clone: F13B10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene