WormBase Tree Display for Gene: WBGene00004397
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| WBGene00004397 | SMap | S_parent | Sequence | T01B7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | rol-6 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T01B7.7 | ||||||||
| Molecular_name | T01B7.7 | ||||||||
| T01B7.7.1 | |||||||||
| CE03591 | |||||||||
| Other_name | CELE_T01B7.7 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | rol-6 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rol | ||||||||
| Reference_allele | WBVar00143020 | ||||||||
| Allele (70) | |||||||||
| Legacy_information | e187 : adults L3 and L4 larvae right-handed rollers. ES3 (adults late larvae). ME0. Similar phenotype in e187/Df. NA (recessive) 7 (sc90 : no phenotype alone but fails to complement e187). Null phenotype may be wildtype. Also Class 3 (neomorphic) allele su1006dm : both su1006 and su1006/+ severe right-handed rollers in L3 L4 adult; phenotype more extreme than e187. | ||||||||
| See also e187, n1177, n1178, n1268, n1269, n1270, n1271, n1272 | |||||||||
| [C.elegansII] e187 : adults, L3 and L4 larvae right-handed rollers. ES3 (adults, late larvae). ME0. Similar phenotype in e187/Df. OA6 (recessive): sc90, n1177 (both have no phenotype alone but fail to complement e187). Also intragenic revertants e187n1270 (WT) etc.; null phenotype probably wildtype. Also neomorphic allele:su1006dm (both su1006 and su1006/+ severe right-handed rollers in L3, L4, adult; phenotype more extreme than e187).su1006 widely used as dominant transformation marker (ES3; ME1). Cloned: encodes collagen, sqt-1 family. [Cox et al. 1980; Kramer et al. 1990; Mello etal. 1992; Park and Kramer 1994; CH] | |||||||||
| Strain (34) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00039850 | ||||||||
| 00039851 | |||||||||
| 00039852 | |||||||||
| 00039853 | |||||||||
| 00039854 | |||||||||
| 00039855 | |||||||||
| 00039856 | |||||||||
| 00039857 | |||||||||
| 00112774 | |||||||||
| Ortholog (39) | |||||||||
| Paralog (161) | |||||||||
| Structured_description | Concise_description | The rol-6 gene encodes a cuticle collagen related to human collagen alpha 1 (III) chain precursor (OMIM:120180), and is required for normal cuticular morphology; ROL-6 interacts with SQT-1, a closely related cuticle collagen, and is expressed at all stages from L2 to adult with transcripts detected at each of the molts preceding these stages. | Paper_evidence | WBPaper00001273 | |||||
| WBPaper00001951 | |||||||||
| WBPaper00002665 | |||||||||
| WBPaper00003853 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | A structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Located in collagen and cuticulin-based cuticle extracellular matrix. Expressed in hypodermis. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 5. Is an ortholog of human COLQ (collagen like tail subunit of asymmetric acetylcholinesterase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110667 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2226) | ||||
| Molecular_info | Corresponding_CDS | T01B7.7 | |||||||
| Corresponding_transcript | T01B7.7.1 | ||||||||
| Other_sequence (36) | |||||||||
| Associated_feature | WBsf988805 | ||||||||
| WBsf1012736 | |||||||||
| WBsf221806 | |||||||||
| WBsf221807 | |||||||||
| Experimental_info | RNAi_result (21) | ||||||||
| Expr_pattern | Expr714 | ||||||||
| Expr3828 | |||||||||
| Expr1014037 | |||||||||
| Expr1032207 | |||||||||
| Expr1155717 | |||||||||
| Expr2015404 | |||||||||
| Expr2033639 | |||||||||
| Drives_construct (14) | |||||||||
| Construct_product | WBCnstr00000984 | ||||||||
| WBCnstr00011679 | |||||||||
| WBCnstr00014434 | |||||||||
| WBCnstr00016623 | |||||||||
| WBCnstr00016624 | |||||||||
| WBCnstr00019530 | |||||||||
| WBCnstr00035512 | |||||||||
| WBCnstr00039780 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (321) | |||||||||
| Interaction (292) | |||||||||
| WBProcess | WBbiopr:00000124 | ||||||||
| Map_info | Map | II | Position | 0.871333 | Error | 0.001551 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mnDf16 | |||||||
| mnDf44 | |||||||||
| mnDf45 | |||||||||
| mnDf46 | |||||||||
| mnDf47 | |||||||||
| mnDf48 | |||||||||
| mnDf49 | |||||||||
| mnDf67 | |||||||||
| Positive_clone | C12G12 | ||||||||
| T01B7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Outside_rearr | mDf17 | |||||||
| Mapping_data | 2_point | 217 | |||||||
| 2631 | |||||||||
| 5725 | |||||||||
| 6167 | |||||||||
| 6168 | |||||||||
| 7090 | |||||||||
| Multi_point (29) | |||||||||
| Pos_neg_data (21) | |||||||||
| Reference (367) | |||||||||
| Method | Gene |
