WormBase Tree Display for Gene: WBGene00004395
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| WBGene00004395 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | rol-3 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C16D9.2 | ||||||||
| Molecular_name | C16D9.2 | ||||||||
| C16D9.2.1 | |||||||||
| CE44893 | |||||||||
| Other_name | let-333 | ||||||||
| CELE_C16D9.2 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | rol-3 | ||||||||
| DB_info | Database | AceView | gene | 5I710 | |||||
| WormQTL | gene | WBGene00004395 | |||||||
| WormFlux | gene | WBGene00004395 | |||||||
| NDB | locus_tag | CELE_C16D9.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004395|UniProtKB=Q8I7I5 | |||||||
| family | PTHR24418 | ||||||||
| NCBI | gene | 179204 | |||||||
| RefSeq | protein | NM_001269168.3 | |||||||
| SwissProt | UniProtAcc | Q8I7I5 | |||||||
| UniProt_GCRP | UniProtAcc | Q8I7I5 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rol | ||||||||
| Reference_allele | WBVar00143458 | ||||||||
| Allele (123) | |||||||||
| Legacy_information | e754 : adults left-handed rollers. ES3 (adult) ME1. NA1. | ||||||||
| [Rogalski TM, Rosenbluth RE, Johnsen RC] Number of s alleleles = 11 (as of 01/93). In contrast to the reference allele, e754, these s alleles are recessive lethal mutations. A 12th mutation, s501 induced with 500R gamma radiation, has been renamed sDf57. | |||||||||
| See also e202, e754, s126, s422, s742, s833, s1030, s1040, s1040ts, s1408, s1409, s1473, s1494, s1519 | |||||||||
| [C.elegansII] e754 : adults left-handed rollers. ES3 (adult) ME1. OA1 (viable): e202.Also lethal alleles (high forward mutation rate), OA>10: s126, s422 (pka let-333), s742gri, s833,s1040ts (lethality suppressed by srl-1 orsrl-2), s1408, s1519 etc. Lethal arrest for most alleles early to mid larval. [Cox et al. 1980; Barbazuk et al. 1994; BC] | |||||||||
| Strain | WBStrain00000610 | ||||||||
| WBStrain00000658 | |||||||||
| WBStrain00000691 | |||||||||
| WBStrain00000751 | |||||||||
| WBStrain00004203 | |||||||||
| WBStrain00005459 | |||||||||
| WBStrain00002406 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (33) | |||||||||
| Paralog (47) | |||||||||
| Structured_description | Concise_description | rol-3 was identified in screens for recessive mutations that affect body morphology; strong loss-of-function mutations in rol-3 result in early-to-mid larval lethality, while weaker mutations result in animals that are left-handed rollers at the adult stage only; lethal rol-3 mutations are suppressed by mutations in srl-1 and srl-2. | Paper_evidence | WBPaper00000465 | |||||
| WBPaper00001853 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 08 Sep 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATP binding activity and protein kinase activity. Involved in embryo development and locomotion. Located in cell leading edge and cell periphery. Expressed in head; seam cell; and vulval precursor cell. Is an ortholog of human ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C16D9.2 | |||||||
| Corresponding_CDS_history | C16D9.2:wp90 | ||||||||
| C16D9.2a:wp214 | |||||||||
| C16D9.2b:wp214 | |||||||||
| C16D9.2c:wp214 | |||||||||
| Corresponding_transcript | C16D9.2.1 | ||||||||
| Other_sequence | MH05375 | ||||||||
| JO471540.1 | |||||||||
| OOC02564_1 | |||||||||
| Oden_isotig28774 | |||||||||
| ACC33716_1 | |||||||||
| FC549938.1 | |||||||||
| MHC01849_1 | |||||||||
| FC548009.1 | |||||||||
| JI164136.1 | |||||||||
| Associated_feature | WBsf652834 | ||||||||
| WBsf652835 | |||||||||
| WBsf669151 | |||||||||
| WBsf981967 | |||||||||
| WBsf1000601 | |||||||||
| WBsf1000602 | |||||||||
| WBsf1019993 | |||||||||
| WBsf234052 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr5282 | ||||||||
| Expr5283 | |||||||||
| Expr11036 | |||||||||
| Expr11037 | |||||||||
| Expr1027637 | |||||||||
| Expr1032206 | |||||||||
| Expr1144777 | |||||||||
| Expr2015403 | |||||||||
| Expr2033638 | |||||||||
| Drives_construct | WBCnstr00002551 | ||||||||
| WBCnstr00004374 | |||||||||
| WBCnstr00017709 | |||||||||
| WBCnstr00035513 | |||||||||
| Construct_product | WBCnstr00017710 | ||||||||
| WBCnstr00035513 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (74) | |||||||||
| Map_info | Map | V | Position | 1.24774 | Error | 0.001962 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C16D9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Negative | Negative_clone | T24H5 | |||||||
| Mapping_data | 2_point | 128 | |||||||
| 1771 | |||||||||
| 1772 | |||||||||
| 3565 | |||||||||
| Multi_point (17) | |||||||||
| Pos_neg_data (23) | |||||||||
| Landmark_gene | |||||||||
| Reference (39) | |||||||||
| Remark | Interacting_genes 'srl-1: Suppressor of Rol-3 Lethality. | ||||||||
| Interacting_genes 'srl-2 Suppressor of Rol-3 Lethality. | |||||||||
| Method | Gene |
