WormBase Tree Display for Gene: WBGene00004392

WBGene00004392 SMap: S_parent: Sequence: C03C10
  Identity: Version: 1
    Name: CGC_name: rnr-2 Person_evidence: WBPerson732
      Sequence_name: C03C10.3
      Molecular_name: C03C10.3
        C03C10.3.1
        CE00874
      Other_name: CELE_C03C10.3 Accession_evidence: NDB BX284603
      Public_name: rnr-2
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rnr
    Allele (20)
    Strain: WBStrain00001566
      WBStrain00037537
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog: WBGene00061620 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00039246 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00160406 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00112008 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00061850 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00127416 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00234134 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g4959 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g8303 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g21124 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g6577 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g1367 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g25419 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g11756 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g3820 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g18873 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g18080 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g9858 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00298.g8762 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-rnr-2 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g17509 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00433.g11301 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_02416.g26393 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_11971.g40525 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_11978.g40528 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_07242 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_008870 Caenorhabditis remanei From_analysis: WormBase-Compara
      GCK72_008884 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g01810 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g2604 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g477 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g7680 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g7694 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30000910 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g7371 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00061609 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00239522 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00275324 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00264940 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00291001 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000003412 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      SGD:S000003563 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0011704 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-990415-25 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030616-614 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10452 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:17296 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:98181 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2155865 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1306045 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1598310 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2323655 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00017610 Caenorhabditis elegans From_analysis: Panther
      WBGene00019588 Caenorhabditis elegans From_analysis: Panther
      WBGene00018842 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: rnr-2 encodes the small subunit of ribonucleotide reductase; by homology, RNR-2 is predicted to function in deoxyribonucleotide biosynthesis; in C. elegans rnr-2 is an essential gene whose activity is required for reproduction and embryonic development. Curator_confirmed: WBPerson1843
          Date_last_updated: 02 Aug 2007 00:00:00
      Automated_description: Predicted to enable ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in embryo development. Predicted to be located in cytosol. Expressed in gonad. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; lung non-small cell carcinoma; and mitochondrial DNA depletion syndrome (multiple). Is an ortholog of human RRM2 (ribonucleotide reductase regulatory subunit M2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080127 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17296)
      DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10452)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10452)
      DOID:0070331 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17296)
      DOID:1793 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10452)
      DOID:3459 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10452)
      DOID:0111518 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17296)
  Molecular_info: Corresponding_CDS: C03C10.3
    Corresponding_transcript: C03C10.3.1
    Other_sequence (127)
    Associated_feature (14)
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr4005
      Expr5124
      Expr8343
      Expr8344
      Expr1021420
      Expr1032203
      Expr1143611
      Expr2015399
      Expr2033633
    Drives_construct: WBCnstr00002406
      WBCnstr00035515
    Construct_product: WBCnstr00035515
    Antibody: WBAntibody00001449
    Microarray_results (24)
    Expression_cluster (240)
    Interaction (230)
  Map_info: Map: III Position: -3.80673 Error: 0.007598
    Positive: Positive_clone: C03C10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00032112
    WBPaper00033122
    WBPaper00035098
    WBPaper00035228
    WBPaper00038491
    WBPaper00055090
    WBPaper00061547
    WBPaper00064934
  Remark: Sequence connection from [Boxem M, van den Heuvel S]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene