WormBase Tree Display for Gene: WBGene00004392

WBGene00004392 SMap: S_parent: Sequence: C03C10
  Identity: Version: 1
    Name: CGC_name: rnr-2 Person_evidence: WBPerson732
      Sequence_name: C03C10.3
      Molecular_name: C03C10.3
        C03C10.3.1
        CE00874
      Other_name: CELE_C03C10.3 Accession_evidence: NDB BX284603
      Public_name: rnr-2
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rnr
    Allele (20)
    Strain: WBStrain00001566
      WBStrain00037537
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (52)
    Paralog: WBGene00017610 Caenorhabditis elegans From_analysis: Panther
      WBGene00019588 Caenorhabditis elegans From_analysis: Panther
      WBGene00018842 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: rnr-2 encodes the small subunit of ribonucleotide reductase; by homology, RNR-2 is predicted to function in deoxyribonucleotide biosynthesis; in C. elegans rnr-2 is an essential gene whose activity is required for reproduction and embryonic development. Curator_confirmed: WBPerson1843
          Date_last_updated: 02 Aug 2007 00:00:00
      Automated_description: Predicted to enable ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in embryo development. Predicted to be located in cytosol. Expressed in gonad. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; lung non-small cell carcinoma; and mitochondrial DNA depletion syndrome (multiple). Is an ortholog of human RRM2 (ribonucleotide reductase regulatory subunit M2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080127 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17296)
      DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10452)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10452)
      DOID:0070331 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17296)
      DOID:1793 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10452)
      DOID:3459 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10452)
      DOID:0111518 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17296)
  Molecular_info: Corresponding_CDS: C03C10.3
    Corresponding_transcript: C03C10.3.1
    Other_sequence (127)
    Associated_feature (14)
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr4005
      Expr5124
      Expr8343
      Expr8344
      Expr1021420
      Expr1032203
      Expr1143611
      Expr2015399
      Expr2033633
    Drives_construct: WBCnstr00002406
      WBCnstr00035515
    Construct_product: WBCnstr00035515
    Antibody: WBAntibody00001449
    Microarray_results (24)
    Expression_cluster (240)
    Interaction: WBInteraction000006613
      WBInteraction000006800
      WBInteraction000006841
      WBInteraction000009034
      WBInteraction000009040
      WBInteraction000029119
      WBInteraction000033660
      WBInteraction000033812
      WBInteraction000036353
      WBInteraction000036790
      WBInteraction000037870
      WBInteraction000038547
      WBInteraction000039639
      WBInteraction000039758
      WBInteraction000040097
      WBInteraction000040449
      WBInteraction000040661
      WBInteraction000040662
      WBInteraction000040902
      WBInteraction000041337
      WBInteraction000041470
      WBInteraction000042155
      WBInteraction000042404
      WBInteraction000042493
      WBInteraction000042715
      WBInteraction000043279
      WBInteraction000043499
      WBInteraction000043938
      WBInteraction000045707
      WBInteraction000045787
      WBInteraction000045788
      WBInteraction000046619
      WBInteraction000046725
      WBInteraction000047073
      WBInteraction000047215
      WBInteraction000047216
      WBInteraction000047218
      WBInteraction000047524
      WBInteraction000047525
      WBInteraction000047965
      WBInteraction000048259
      WBInteraction000048276
      WBInteraction000048435
      WBInteraction000048463
      WBInteraction000048999
      WBInteraction000049000
      WBInteraction000049001
      WBInteraction000049002
      WBInteraction000049643
      WBInteraction000050282
      WBInteraction000050283
      WBInteraction000050856
      WBInteraction000103391
      WBInteraction000121062
      WBInteraction000122840
      WBInteraction000122841
      WBInteraction000122842
      WBInteraction000146040
      WBInteraction000146827
      WBInteraction000147834
      WBInteraction000148846
      WBInteraction000149063
      WBInteraction000151355
      WBInteraction000154435
      WBInteraction000154436
      WBInteraction000154437
      WBInteraction000154438
      WBInteraction000154439
      WBInteraction000154440
      WBInteraction000156931
      WBInteraction000176638
      WBInteraction000177430
      WBInteraction000177781
      WBInteraction000179601
      WBInteraction000181555
      WBInteraction000182092
      WBInteraction000184724
      WBInteraction000189995
      WBInteraction000191734
      WBInteraction000198090
      WBInteraction000198850
      WBInteraction000202278
      WBInteraction000202370
      WBInteraction000203341
      WBInteraction000204740
      WBInteraction000206469
      WBInteraction000206672
      WBInteraction000210207
      WBInteraction000211803
      WBInteraction000212686
      WBInteraction000213723
      WBInteraction000216537
      WBInteraction000223548
      WBInteraction000226851
      WBInteraction000229588
      WBInteraction000229820
      WBInteraction000229857
      WBInteraction000232353
      WBInteraction000238378
      WBInteraction000239295
      WBInteraction000242270
      WBInteraction000245081
      WBInteraction000246107
      WBInteraction000251015
      WBInteraction000251272
      WBInteraction000252150
      WBInteraction000252889
      WBInteraction000253310
      WBInteraction000254945
      WBInteraction000255361
      WBInteraction000260694
      WBInteraction000261989
      WBInteraction000262834
      WBInteraction000265725
      WBInteraction000268949
      WBInteraction000275031
      WBInteraction000279540
      WBInteraction000279641
      WBInteraction000280013
      WBInteraction000281104
      WBInteraction000285102
      WBInteraction000285113
      WBInteraction000286480
      WBInteraction000286997
      WBInteraction000288999
      WBInteraction000290386
      WBInteraction000292082
      WBInteraction000292494
      WBInteraction000300652
      WBInteraction000306665
      WBInteraction000306942
      WBInteraction000309215
      WBInteraction000309463
      WBInteraction000309468
      WBInteraction000309699
      WBInteraction000311093
      WBInteraction000313876
      WBInteraction000315174
      WBInteraction000315587
      WBInteraction000315825
      WBInteraction000316193
      WBInteraction000316303
      WBInteraction000319328
      WBInteraction000319817
      WBInteraction000326178
      WBInteraction000326187
      WBInteraction000327253
      WBInteraction000328053
      WBInteraction000329068
      WBInteraction000333455
      WBInteraction000334120
      WBInteraction000335270
      WBInteraction000335936
      WBInteraction000337271
      WBInteraction000338677
      WBInteraction000339973
      WBInteraction000342454
      WBInteraction000342548
      WBInteraction000346409
      WBInteraction000346618
      WBInteraction000347682
      WBInteraction000348097
      WBInteraction000349796
      WBInteraction000351213
      WBInteraction000354329
      WBInteraction000354649
      WBInteraction000355559
      WBInteraction000357362
      WBInteraction000357414
      WBInteraction000357487
      WBInteraction000357609
      WBInteraction000358952
      WBInteraction000362783
      WBInteraction000364751
      WBInteraction000367007
      WBInteraction000367686
      WBInteraction000371022
      WBInteraction000371803
      WBInteraction000376674
      WBInteraction000379788
      WBInteraction000388909
      WBInteraction000392586
      WBInteraction000392983
      WBInteraction000393740
      WBInteraction000394930
      WBInteraction000396279
      WBInteraction000399507
      WBInteraction000400968
      WBInteraction000401728
      WBInteraction000404350
      WBInteraction000411532
      WBInteraction000418578
      WBInteraction000419175
      WBInteraction000423024
      WBInteraction000423161
      WBInteraction000424582
      WBInteraction000425158
      WBInteraction000425437
      WBInteraction000427327
      WBInteraction000431967
      WBInteraction000432221
      WBInteraction000433608
      WBInteraction000433829
      WBInteraction000435391
      WBInteraction000438490
      WBInteraction000442050
      WBInteraction000444929
      WBInteraction000448616
      WBInteraction000450371
      WBInteraction000453933
      WBInteraction000456630
      WBInteraction000456718
      WBInteraction000456916
      WBInteraction000457372
      WBInteraction000459999
      WBInteraction000460968
      WBInteraction000463678
      WBInteraction000464406
      WBInteraction000465339
      WBInteraction000466147
      WBInteraction000467713
      WBInteraction000467811
      WBInteraction000472624
      WBInteraction000475371
      WBInteraction000504172
      WBInteraction000514702
      WBInteraction000570608
      WBInteraction000577695
      WBInteraction000580298
      WBInteraction000582602
  Map_info: Map: III Position: -3.80673 Error: 0.007598
    Positive: Positive_clone: C03C10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00032112
    WBPaper00033122
    WBPaper00035098
    WBPaper00035228
    WBPaper00038491
    WBPaper00055090
    WBPaper00061547
    WBPaper00064934
  Remark: Sequence connection from [Boxem M, van den Heuvel S]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene