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WormBase Tree Display for Gene: WBGene00004367

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Name Class

WBGene00004367SMapS_parentSequenceY69A2AR
IdentityVersion1
NameCGC_nameric-8Person_evidenceWBPerson508
Sequence_nameY69A2AR.2
Molecular_name (13)
Other_nameCELE_Y69A2AR.2Accession_evidenceNDBBX284604
Public_nameric-8
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:35WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classric
Allele (179)
StrainWBStrain00002734
WBStrain00023477
WBStrain00033385
WBStrain00033390
WBStrain00037694
RNASeq_FPKM (74)
GO_annotation (20)
Contained_in_operonCEOP4064
OrthologWBGene00071906Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00034564Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00155895Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00227273Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g11491Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g4612Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g12977Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g2355Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g13593Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g10207Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g6452Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g6850Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g1521Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g1682Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00123.g4979Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-ric-8Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold630.g18960Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_04081.g32014Caenorhabditis sinicaFrom_analysisWormBase-Compara
Csp5_scaffold_04574.g33256Caenorhabditis sinicaFrom_analysisWormBase-Compara
GCK72_015398Caenorhabditis remaneiFrom_analysisWormBase-Compara
GCK72_015399Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g09042Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g11084Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_40004700Caenorhabditis inopinataFrom_analysisWormBase-Compara
Sp34_40004800Caenorhabditis inopinataFrom_analysisWormBase-Compara
Sp34_40033600Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrIV_pilon.g9835Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00210859Caenorhabditis japonicaFrom_analysisWormBase-Compara
WBGene00071907Caenorhabditis remaneiFrom_analysisWormBase-Compara
WBGene00243576Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00097113Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00263037Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00287664Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0028292Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-030131-6435Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-040927-18Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ZFIN:ZDB-GENE-131121-183Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-121214-276Danio rerioFrom_analysisEnsEMBL-Compara
OrthoFinder
OrthoInspector
PhylomeDB
HGNC:25555Homo sapiensFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:29550Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:2141866Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
MGI:2682307Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:727957Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
RGD:631419Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
Structured_descriptionConcise_descriptionric-8 encodes a receptor-independent G alpha guanine nucleotide exchange factor (GEF); ric-8 activity is required for regulating heterotrimeric G protein signaling pathways that control asymmetric cell division in the embryo as well as synaptic transmission in the nervous system; in the 1-cell embryo, RIC-8 functions as a GEF for GOA-1 thereby regulating spindle morphology, position, and consequently, the first asymmetric cell division; in the nervous system, RIC-8 likely functions to regulate activity of both the EGL-30 and GSA-1 pathways to regulate neurotransmitter secretion and thus, coordinated locomotion; RIC-8 also functions, with AGS-3, to activate GOA-1/Galpha0 in the ASH chemosensory neurons to modulate behavior after food deprivation; in vitro, RIC-8 preferentially binds GOA-1-GDP and increases the rate of GOA-1 GTP binding; in the early embryo, RIC-8 localizes to the cellular cortex, junctions between cells, asters of the mitotic spindle, the central spindle (kinetochore microtubules), the nuclear envelope, and chromatin; RIC-8's localization to the cortex and asters mirrors that of GOA-1, while localization to the cortex and central spindle is similar to that of the GOA-1 regulators GPR-1/2, whose subcellular localization is RIC-8-dependent; in later stage animals, RIC-8 is seen in head and tail ganglia, amphid processes, and the ventral nerve cord, as well as in larval nonneuronal cells, such as germline nuclei, where it localizes near the nuclear membrane.Paper_evidenceWBPaper00002590
WBPaper00004296
WBPaper00004446
WBPaper00024480
WBPaper00024481
WBPaper00024543
WBPaper00024986
WBPaper00040078
Curator_confirmedWBPerson1843
Date_last_updated19 Aug 2011 00:00:00
Automated_descriptionEnables guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of protein kinase C signaling; protein localization to cell cortex; and regulation of feeding behavior. Located in aster; cell cortex; and kinetochore microtubule. Expressed in germ line and neurons. Is an ortholog of human RIC8A (RIC8 guanine nucleotide exchange factor A).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSY69A2AR.2a
Y69A2AR.2b
Y69A2AR.2c
Y69A2AR.2d
Corresponding_transcriptY69A2AR.2a.1
Y69A2AR.2b.1
Y69A2AR.2c.1
Y69A2AR.2d.1
Y69A2AR.2d.2
Other_sequence (23)
Associated_featureWBsf995737
WBsf995738
WBsf1016925
WBsf228040
WBsf228041
WBsf228042
Experimental_info (9)
Map_infoMapIVPosition-6.76529Error0.01152
PositivePositive_cloneY69A2ARInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point3915
5262
5671
Reference (53)
MethodGene