WormBase Tree Display for Gene: WBGene00004367
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| WBGene00004367 | SMap | S_parent | Sequence | Y69A2AR | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ric-8 | Person_evidence | WBPerson508 | |||||
| Sequence_name | Y69A2AR.2 | ||||||||
| Molecular_name (13) | |||||||||
| Other_name | CELE_Y69A2AR.2 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | ric-8 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ric | ||||||||
| Allele (179) | |||||||||
| Strain | WBStrain00002734 | ||||||||
| WBStrain00023477 | |||||||||
| WBStrain00033385 | |||||||||
| WBStrain00033390 | |||||||||
| WBStrain00037694 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Contained_in_operon | CEOP4064 | ||||||||
| Ortholog (44) | |||||||||
| Structured_description | Concise_description | ric-8 encodes a receptor-independent G alpha guanine nucleotide exchange factor (GEF); ric-8 activity is required for regulating heterotrimeric G protein signaling pathways that control asymmetric cell division in the embryo as well as synaptic transmission in the nervous system; in the 1-cell embryo, RIC-8 functions as a GEF for GOA-1 thereby regulating spindle morphology, position, and consequently, the first asymmetric cell division; in the nervous system, RIC-8 likely functions to regulate activity of both the EGL-30 and GSA-1 pathways to regulate neurotransmitter secretion and thus, coordinated locomotion; RIC-8 also functions, with AGS-3, to activate GOA-1/Galpha0 in the ASH chemosensory neurons to modulate behavior after food deprivation; in vitro, RIC-8 preferentially binds GOA-1-GDP and increases the rate of GOA-1 GTP binding; in the early embryo, RIC-8 localizes to the cellular cortex, junctions between cells, asters of the mitotic spindle, the central spindle (kinetochore microtubules), the nuclear envelope, and chromatin; RIC-8's localization to the cortex and asters mirrors that of GOA-1, while localization to the cortex and central spindle is similar to that of the GOA-1 regulators GPR-1/2, whose subcellular localization is RIC-8-dependent; in later stage animals, RIC-8 is seen in head and tail ganglia, amphid processes, and the ventral nerve cord, as well as in larval nonneuronal cells, such as germline nuclei, where it localizes near the nuclear membrane. | Paper_evidence | WBPaper00002590 | |||||
| WBPaper00004296 | |||||||||
| WBPaper00004446 | |||||||||
| WBPaper00024480 | |||||||||
| WBPaper00024481 | |||||||||
| WBPaper00024543 | |||||||||
| WBPaper00024986 | |||||||||
| WBPaper00040078 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 19 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of protein kinase C signaling; protein localization to cell cortex; and regulation of feeding behavior. Located in aster; cell cortex; and kinetochore microtubule. Expressed in germ line and neurons. Is an ortholog of human RIC8A (RIC8 guanine nucleotide exchange factor A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y69A2AR.2a | |||||||
| Y69A2AR.2b | |||||||||
| Y69A2AR.2c | |||||||||
| Y69A2AR.2d | |||||||||
| Corresponding_transcript | Y69A2AR.2a.1 | ||||||||
| Y69A2AR.2b.1 | |||||||||
| Y69A2AR.2c.1 | |||||||||
| Y69A2AR.2d.1 | |||||||||
| Y69A2AR.2d.2 | |||||||||
| Other_sequence (23) | |||||||||
| Associated_feature | WBsf995737 | ||||||||
| WBsf995738 | |||||||||
| WBsf1016925 | |||||||||
| WBsf228040 | |||||||||
| WBsf228041 | |||||||||
| WBsf228042 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00062802 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00058038 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076838 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00021307 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00102067 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062799 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063011 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00000338 | ||||||||
| WBCnstr00003264 | |||||||||
| WBCnstr00011143 | |||||||||
| WBCnstr00012139 | |||||||||
| WBCnstr00035535 | |||||||||
| Construct_product | WBCnstr00000336 | ||||||||
| WBCnstr00011143 | |||||||||
| WBCnstr00035535 | |||||||||
| Antibody | WBAntibody00000300 | ||||||||
| WBAntibody00000791 | |||||||||
| WBAntibody00000944 | |||||||||
| WBAntibody00002825 | |||||||||
| WBAntibody00002826 | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (88) | |||||||||
| Interaction (45) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| Map_info | Map | IV | Position | -6.76529 | Error | 0.01152 | |||
| Positive | Positive_clone | Y69A2AR | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 3915 | |||||||
| 5262 | |||||||||
| 5671 | |||||||||
| Reference (53) | |||||||||
| Method | Gene |
