WormBase Tree Display for Gene: WBGene00004363
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| WBGene00004363 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | T14A8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ric-3 | Person_evidence | WBPerson508 | |||||
| Sequence_name | T14A8.1 | ||||||||
| Molecular_name | T14A8.1 | ||||||||
| T14A8.1.1 | |||||||||
| CE27448 | |||||||||
| Other_name | des-5 | ||||||||
| CELE_T14A8.1 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | ric-3 | ||||||||
| DB_info | Database | AceView | gene | 4I585 | |||||
| WormQTL | gene | WBGene00004363 | |||||||
| WormFlux | gene | WBGene00004363 | |||||||
| NDB | locus_tag | CELE_T14A8.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004363|UniProtKB=Q22472 | |||||||
| family | PTHR21723 | ||||||||
| NCBI | gene | 177570 | |||||||
| RefSeq | protein | NM_068898.7 | |||||||
| SwissProt | UniProtAcc | Q22472 | |||||||
| TREEFAM | TREEFAM_ID | TF317692 | |||||||
| UniProt_GCRP | UniProtAcc | Q22472 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ric | ||||||||
| Allele (36) | |||||||||
| Legacy_information | [Rand JB] Unc, small, slow growing, resistant to cholinesterase inhibitors | ||||||||
| [M Treinin] suppression of deg-3(u662) induced degenerations, Coilers, Levamisole resistance, Aldicarb resistance, pharyngeal pumping defect, temperature sensitive growth | |||||||||
| Complementation_data | [Rand JB] complements unc-5, unc-8, unc-24, unc-43, unc-44 | ||||||||
| Strain | WBStrain00026485 | ||||||||
| WBStrain00033372 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (33) | |||||||||
| Structured_description | Concise_description | ric-3 encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; RIC-3 is necessary for the maturation and function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor; RIC-3 levels and hence, activity, are regulated by BATH-42, a BTB and MATH domain-containing protein, with which RIC-3 interacts in vitro; as BATH-42 also interacts with the CUL-3 cullin, RIC-3 levels are thus likely regulated by a CUL-3-containing ubiquitin ligase complex. | Paper_evidence | WBPaper00005151 | |||||
| WBPaper00025230 | |||||||||
| WBPaper00032915 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Feb 2009 00:00:00 | ||||||||
| Automated_description | Enables protein folding chaperone. Involved in several processes, including cholinergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and protein localization to cell surface. Located in intracellular membrane-bounded organelle; neuron projection; and neuronal cell body. Expressed in body wall musculature; neurons; and pharyngeal muscle cell. Is an ortholog of human RIC3 (RIC3 acetylcholine receptor chaperone). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T14A8.1 | |||||||
| Corresponding_transcript | T14A8.1.1 | ||||||||
| Other_sequence (19) | |||||||||
| Associated_feature | WBsf646116 | ||||||||
| WBsf997051 | |||||||||
| WBsf997052 | |||||||||
| WBsf1017761 | |||||||||
| WBsf228581 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr1841 | ||||||||
| Expr1015755 | |||||||||
| Expr1032178 | |||||||||
| Expr1156889 | |||||||||
| Expr2015346 | |||||||||
| Expr2033580 | |||||||||
| Drives_construct | WBCnstr00000299 | ||||||||
| WBCnstr00035537 | |||||||||
| Construct_product | WBCnstr00035537 | ||||||||
| Antibody | WBAntibody00001494 | ||||||||
| WBAntibody00001724 | |||||||||
| WBAntibody00002709 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (171) | |||||||||
| Interaction (44) | |||||||||
| Map_info | Map | IV | Position | 3.49037 | Error | 0.000987 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | T14A8 | Person_evidence | WBPerson661 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Negative | Negative_clone | C33H5 | Person_evidence | WBPerson661 | |||||
| Mapping_data | Multi_point | 2009 | |||||||
| 4320 | |||||||||
| 4464 | |||||||||
| Reference (47) | |||||||||
| Remark | previously appeared as des-5 | ||||||||
| Sequence connection from [Halevi S, Treinin M] | |||||||||
| Method | Gene |
