WormBase Tree Display for Gene: WBGene00004311

WBGene00004311 SMap: S_parent: Sequence: F17C8
  Identity: Version: 1
    Name: CGC_name: ras-2
      Sequence_name: F17C8.4
      Molecular_name: F17C8.4
        F17C8.4.1
        CE00958
        F17C8.4.2
      Other_name: Ras2 Accession_evidence: EMBL U80675
        CELE_F17C8.4 Accession_evidence: NDB BX284603
      Public_name: ras-2
    DB_info: Database: AceView gene 3F828
        WormQTL gene WBGene00004311
        WormFlux gene WBGene00004311
        NDB locus_tag CELE_F17C8.4
        Panther gene CAEEL|WormBase=WBGene00004311|UniProtKB=G5EGA7
          family PTHR24070
        NCBI gene 175625
        RefSeq protein NM_065571.7
        TrEMBL UniProtAcc G5EGA7
        UniProt_GCRP UniProtAcc G5EGA7
        OMIM gene 608435
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ras
    Allele (24)
    Strain: WBStrain00031565
    RNASeq_FPKM (74)
    GO_annotation: 00019840
      00019841
      00019842
      00019843
      00112656
      00112657
      00112658
      00112659
    Ortholog (36)
    Paralog (14)
    Structured_description: Concise_description: ras-2 encodes member of the Ras subfamily of RAS small GTPases with highest similarity to human M-Ras Curator_confirmed: WBPerson48
          Date_last_updated: 09 Aug 2004 00:00:00
      Automated_description: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in signal transduction. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome 11. Is an ortholog of human MRAS (muscle RAS oncogene homolog). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0112169 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7227)
  Molecular_info: Corresponding_CDS: F17C8.4
    Corresponding_transcript: F17C8.4.1
      F17C8.4.2
    Other_sequence (23)
    Associated_feature: WBsf716734
      WBsf992204
      WBsf1014798
      WBsf226568
  Experimental_info: RNAi_result: WBRNAi00005467 Inferred_automatically: RNAi_primary
      WBRNAi00027695 Inferred_automatically: RNAi_primary
      WBRNAi00044885 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1014042
      Expr1032136
      Expr1148851
      Expr2015261
      Expr2033495
    Drives_construct: WBCnstr00035572
    Construct_product: WBCnstr00017961
      WBCnstr00035572
    Microarray_results (23)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_CoreEnriched
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00045521:Spermatogenic
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048988:daf-2(e1370)_daf-16(mu86)_downregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053599:mitosis_vs_meiosis_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056218:daf-16(mu86)_upregulated_Day5
      WBPaper00056284:ints-5(RNAi)_upregulated
      WBPaper00056293:rpl-5(0)-rpl-33(0)_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056826:SGP_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061045:Y56A3A.22(cck200)_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:P_cell
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061390:daf-22(ok693)_ascarosides_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061466:nath-10(icb99)_upregulated
      WBPaper00061527:dhs-28_22199-acs-14
      WBPaper00061818:ELKS-1_interacting
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064735:bet-1(uth41)_vs_N2_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065841:2_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025032:cluster_16
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00027342:alpha-Synuclein(WT)_upregulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00032948:StarveUp2
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_I
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040876:mir-35_upregulated
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(122_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(122_min)
      [cgc6390]:Cluster_A
    Interaction: WBInteraction000162490
      WBInteraction000167517
      WBInteraction000339776
      WBInteraction000441986
      WBInteraction000578799
      WBInteraction000579485
  Map_info: Map: III Position: -2.6181 Error: 0.007804
    Positive: Positive_clone: F17C8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4625
        5500
    Pseudo_map_position
  Reference: WBPaper00014573
    WBPaper00015190
    WBPaper00027296
    WBPaper00038491
    WBPaper00040813
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene