WormBase Tree Display for Gene: WBGene00004264
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WBGene00004264 | Evidence | Person_evidence | WBPerson83 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_II | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | qua-1 | Person_evidence | WBPerson83 | |||||
Sequence_name | T05C12.10 | ||||||||
Molecular_name | T05C12.10 | ||||||||
T05C12.10.1 | |||||||||
CE34989 | |||||||||
Other_name | CELE_T05C12.10 | Accession_evidence | NDB | BX284602 | |||||
Public_name | qua-1 | ||||||||
DB_info | Database | AceView | gene | 2I493 | |||||
WormQTL | gene | WBGene00004264 | |||||||
WormFlux | gene | WBGene00004264 | |||||||
NDB | locus_tag | CELE_T05C12.10 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00004264|UniProtKB=G5EC21 | |||||||
family | PTHR46706 | ||||||||
NCBI | gene | 174319 | |||||||
RefSeq | protein | NM_063324.5 | |||||||
SwissProt | UniProtAcc | G5EC21 | |||||||
TREEFAM | TREEFAM_ID | TF106458 | |||||||
UniProt_GCRP | UniProtAcc | G5EC21 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | qua | ||||||||
Allele (70) | |||||||||
Strain | WBStrain00002356 | ||||||||
WBStrain00035500 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (11) | |||||||||
Ortholog (31) | |||||||||
Paralog (24) | |||||||||
Structured_description | Concise_description | qua-1 encodes a hedgehog-like protein, with (from N- to C-terminus) asignal sequence, a Qua domain, a 5W repeat, an extended region oflow-complexity sequence, and a Hint/Hog domain; QUA-1 is conserved amongnematodes from Caenorhabditis to Brugia; QUA-1 is expressed prior tomolting in hyp1 to hyp11 hypodermal cells, but not in seam cells, andceases to be expressed after each molting cycle or in gravid adults nolonger molting; QUA-1 is strongly required for normal molting, withlethal molting defects in qua-1 mutants and severe defects inqua-1(RNAi) animals; similar molting defects in RNAi of ptr-4 and ptr-23(encoding Dispatched homologs) suggest that PTR-4 and PTR-23 may exportQUA-1 from hypodermal cells synthesizing it; other sites of QUA-1expression include intestinal and rectal cells, excretory duct and porecells, sensilla support cells, the P cell lineage in L1, body wallmuscle, and the adult reproductive system; QUA-1 is also required fornormal adult alae formation, growth to full size, cuticle adhesion,locomotion, and male tail development; the Hint/Hog domain is predictedto cut QUA-1 into two halves and then covalently link cholesterol to theC-terminus of the Qua domain; the Qua domain is predicted to form acysteine-crosslinked protein involved in intercellular signalling, andthe Qua domain has subtle similarity to the N-terminal Hedge domain ofHEDGEHOG proteins; both Qua and Hint/Hog domains are required fortransgenic rescue of a lethal qua-1 allele; defects in both qua-1mutants and qua-1(RNAi) animals; all of QUA-1's functions may reflectcommon defects in cholesterol-dependent hedgehog-like signalling. | Paper_evidence | WBPaper00003717 | |||||
WBPaper00006525 | |||||||||
WBPaper00026763 | |||||||||
WBPaper00026841 | |||||||||
WBPaper00027129 | |||||||||
WBPaper00027263 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 05 Nov 2006 00:00:00 | ||||||||
Automated_description | Involved in molting cycle and nematode larval development. Acts upstream of or within nematode male tail mating organ morphogenesis. Located in collagen and cuticulin-based cuticle extracellular matrix. Expressed in several structures, including P1; P12; P2; excretory system; and hypodermal cell. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | T05C12.10 | |||||||
Corresponding_CDS_history | T05C12.10:wp106 | ||||||||
Corresponding_transcript | T05C12.10.1 | ||||||||
Other_sequence (40) | |||||||||
Associated_feature | WBsf657206 | ||||||||
WBsf657945 | |||||||||
WBsf988670 | |||||||||
WBsf988671 | |||||||||
WBsf1012657 | |||||||||
WBsf1012658 | |||||||||
WBsf221705 | |||||||||
WBsf221706 | |||||||||
Experimental_info | RNAi_result (33) | ||||||||
Expr_pattern (11) | |||||||||
Drives_construct | WBCnstr00002958 | ||||||||
WBCnstr00004471 | |||||||||
WBCnstr00006893 | |||||||||
WBCnstr00011601 | |||||||||
WBCnstr00011933 | |||||||||
WBCnstr00015885 | |||||||||
WBCnstr00035603 | |||||||||
Construct_product | WBCnstr00015885 | ||||||||
WBCnstr00035603 | |||||||||
Microarray_results (19) | |||||||||
Expression_cluster (324) | |||||||||
Interaction (169) | |||||||||
WBProcess | WBbiopr:00000123 | ||||||||
Map_info | Map | II | Position | 0.749646 | Error | 0.000106 | |||
Positive | Positive_clone | T05C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4617 | |||||||
Pseudo_map_position | |||||||||
Reference (18) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |