WormBase Tree Display for Gene: WBGene00004222

WBGene00004222 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F44F4
  Identity: Version: 1
    Name: CGC_name: ptr-8 Person_evidence: WBPerson349
      Sequence_name: F44F4.4
      Molecular_name: F44F4.4
        F44F4.4.1
        CE01000
      Other_name: CELE_F44F4.4 Accession_evidence: NDB BX284602
      Public_name: ptr-8
    DB_info: Database: AceView gene 2L183
        WormQTL gene WBGene00004222
        WormFlux gene WBGene00004222
        NDB locus_tag CELE_F44F4.4
        Panther gene CAEEL|WormBase=WBGene00004222|UniProtKB=Q20404
          family PTHR10796
        NCBI gene 174678
        RefSeq protein NM_063942.6
        TREEFAM TREEFAM_ID TF331806
        TrEMBL UniProtAcc Q20404
        UniProt_GCRP UniProtAcc Q20404
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ptr
    Allele (61)
    RNASeq_FPKM (74)
    GO_annotation: 00068055
      00068056
      00068057
      00068058
      00068059
      00068060
      00112512
    Ortholog (27)
    Paralog (30)
    Structured_description: Concise_description: ptr-8 encodes a nematode-specific member of the sterol sensing domain(SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) andhuman PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-8 isweakly required for normal molting from L4 to adult stages; PTR-8 isalso required for normal growth to full size and locomotion; PTR-8 isexpressed in hypodermis. Paper_evidence: WBPaper00004265
            WBPaper00026596
            WBPaper00026841
            WBPaper00027263
          Curator_confirmed: WBPerson48
            WBPerson567
          Date_last_updated: 08 Nov 2006 00:00:00
      Automated_description: Involved in molting cycle. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Expressed in hypodermis and rectum. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F44F4.4
    Corresponding_transcript: F44F4.4.1
    Other_sequence: Name_isotig02160
      Dviv_isotig21035
      Dviv_isotig21036
      Acan_isotig07632
      Oden_isotig19722
      Dviv_isotig20408
    Associated_feature: WBsf989520
      WBsf222082
  Experimental_info: RNAi_result (7)
    Expr_pattern: Expr2067
      Expr1017982
      Expr1151174
      Expr2015174
      Expr2033412
    Drives_construct: WBCnstr00035627
    Construct_product: WBCnstr00035627
    Microarray_results (17)
    Expression_cluster: WBPaper00031040:Cluster_3
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032425:down_in_alg-1
      WBPaper00032425:down_in_zfp-1
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00034761:hlh-30_downregulated
      WBPaper00037849:sam-10(js94)_upregulated
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00044037:eat-2_upregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045017:blmp-1(tm548)_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_upregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046858:elt-2(RNAi)_downregulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched
      WBPaper00048690:male-Z1-Z4-daughter_enriched
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049134:hpk-1(pk1393)_upregulated
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050332:juglone_upregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050496:unc-39(hp701)_regulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_20C_upregulated
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051388:Glucose-diet_upregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053140:IncreasingResponse_20nmAgCit
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054191:H3.3(null)_embryo_upregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055013:hmg-4(RNAi)_upregulated
      WBPaper00055013:spt-16(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056169:rrf-3(pk1426)_upregulated_L3
      WBPaper00056218:daf-16(mu86)_upregulated_Day3
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056617:adr-1_upregulated_embryo_transcript
      WBPaper00056826:SGP_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057068:Cadmium_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059537:ngn-1(ok2200)_upregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_downregulated_N2
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
      WBPaper00059739:hira-1(gk835598)_upregulated_L4
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
      WBPaper00060445:ikb-1(nr2027)_upregulated_L1
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060871:M.humicola-infection_24h_regulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:snt-4_17845-T27C4.1
      WBPaper00061653:alh-4(hj221)_downregulated
      WBPaper00061823:mex-3(spr9)_downregulated
      WBPaper00062118:neural-HSF-1_upregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062347:blmp-1(tm548)_upregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062354:H.zoospora_12h_regulated
      WBPaper00062456:doxycycline_upregulated_N2_protein
      WBPaper00062715:blmp-1(s71)_upregulated
      WBPaper00063926:chd-7(gk290)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064762:freezing-thaw_regulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065759:dot-1.1(knu339)_upregulated
      WBPaper00065841:0_0
      WBPaper00065841:21_0
      WBPaper00065841:21_1
      WBPaper00065841:30_1
      WBPaper00065841:30_2
      WBPaper00065841:33_0
      WBPaper00065841:33_1
      WBPaper00065841:34_0
      WBPaper00065841:34_1
      WBPaper00065841:79_0
      WBPaper00065841:79_2
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00028948:cep-1(gk138)_upregulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_upregulated
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_I
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00041211:RPW-24_Up
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042067:Cu2+_upregulated_WT
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00045015:acs-3(ft5)_upregulated
      WBPaper00045015:nhr-25(RNAi)_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
      WBPaper00053827:pyoverdine_upregulated
      WBPaper00055899:nitroguanidine_regulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:Cluster_B
    Interaction: WBInteraction000140439
      WBInteraction000141398
      WBInteraction000351878
      WBInteraction000385069
      WBInteraction000406657
      WBInteraction000407281
      WBInteraction000409575
      WBInteraction000453122
      WBInteraction000472506
  Map_info: Map: II Position: 3.13127 Error: 9.3e-05
    Positive: Positive_clone: F44F4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00004265
    WBPaper00025183
    WBPaper00026596
    WBPaper00026841
    WBPaper00038491
    WBPaper00055090
    WBPaper00062715
    WBPaper00066265
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene