WormBase Tree Display for Gene: WBGene00004210

WBGene00004210 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: Y110A2AL
  Identity: Version: 1
    Name: CGC_name: ptc-3 Person_evidence: WBPerson349
      Sequence_name: Y110A2AL.8
      Molecular_name: Y110A2AL.8a
        Y110A2AL.8a.1
        CE37163
        Y110A2AL.8b
        CE37164
        Y110A2AL.8c
        CE42182
        Y110A2AL.8b.1
        Y110A2AL.8c.1
      Other_name: Y110A2AL.j Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y110A2AL.8 Accession_evidence: NDB BX284602
      Public_name: ptc-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ptc
    Allele: WBVar01846596
      WBVar01499702
      WBVar01576570
      WBVar01993906
      WBVar01790569
      WBVar01790570
      WBVar01790571
      WBVar01790572
      WBVar01790573
      WBVar01790574
      WBVar01826530
      WBVar00265925
      WBVar00265926
      WBVar02113443
      WBVar01412949
      WBVar01412950
      WBVar01412952
      WBVar02084557
      WBVar01490712
      WBVar02028966
      WBVar02121367
      WBVar02092107
      WBVar01915927
      WBVar02092108
      WBVar01915928
      WBVar01500106
      WBVar02097634
      WBVar01243252
      WBVar01243263
      WBVar01499387
      WBVar01499388
      WBVar01243274
      WBVar02119923
      WBVar02124159
      WBVar00251790
      WBVar01365407
      WBVar00167996
      WBVar00167997
      WBVar01365416
      WBVar02108705
      WBVar00167998
      WBVar00167999
      WBVar00168000
      WBVar00360286
      WBVar00168001
      WBVar00360287
      WBVar00168002
      WBVar00360288
      WBVar00168003
      WBVar00714992
      WBVar00360289
      WBVar00168004
      WBVar00714993
      WBVar00360290
      WBVar00168005
      WBVar00168006
      WBVar00360291
      WBVar00714994
      WBVar00360292
      WBVar00168007
      WBVar00714995
      WBVar00360293
      WBVar00714996
      WBVar00168008
      WBVar00714997
      WBVar00360294
      WBVar02017709
      WBVar00268316
      WBVar00714998
      WBVar00360295
      WBVar00360296
      WBVar00714999
      WBVar00715000
      WBVar00360297
      WBVar00715001
      WBVar00360298
      WBVar00236971
      WBVar00360299
      WBVar01493346
      WBVar00715002
      WBVar00236972
      WBVar00360300
      WBVar01765138
      WBVar00715003
      WBVar01765139
      WBVar00715004
      WBVar00360301
      WBVar01765140
      WBVar00715005
      WBVar00360302
      WBVar00360303
      WBVar00715006
      WBVar00360304
      WBVar00715007
      WBVar00715008
      WBVar00277520
      WBVar01393071
      WBVar00715009
      WBVar00715010
      WBVar01393074
      WBVar01959558
      WBVar00715011
      WBVar01234165
      WBVar01959559
      WBVar01234166
      WBVar00715012
      WBVar01959560
      WBVar01234168
      WBVar00715013
      WBVar01234169
      WBVar00715014
      WBVar01234170
      WBVar00715015
      WBVar00715016
      WBVar01234173
      WBVar00715017
      WBVar00715018
      WBVar01300081
      WBVar01234176
      WBVar00715019
      WBVar01234178
      WBVar01300103
      WBVar01234183
      WBVar00715020
      WBVar02122912
      WBVar00715021
      WBVar01234186
      WBVar00715022
      WBVar01234189
      WBVar00715023
      WBVar00715024
      WBVar00715025
      WBVar00715026
      WBVar00715028
      WBVar00715029
      WBVar00547330
      WBVar00715030
      WBVar02068108
      WBVar01503679
      WBVar00715031
      WBVar02111696
      WBVar00248319
      WBVar01503680
      WBVar00715032
      WBVar00715033
      WBVar01503681
      WBVar01503682
      WBVar00715034
      WBVar00715035
      WBVar01503683
      WBVar00715036
      WBVar01503684
      WBVar02129565
      WBVar01503685
      WBVar00715037
      WBVar02129566
      WBVar01503686
      WBVar00715038
      WBVar00715039
      WBVar00715040
      WBVar01988956
      WBVar00715041
      WBVar01718930
      WBVar00715042
      WBVar01718931
      WBVar02052763
      WBVar01718932
      WBVar00715043
      WBVar01536745
      WBVar00715044
      WBVar01536746
      WBVar00715045
      WBVar00715046
      WBVar01817611
      WBVar01817612
      WBVar00305119
      WBVar01894888
      WBVar01894889
      WBVar01894890
      WBVar01404429
      WBVar01436716
      WBVar01436718
      WBVar00215119
      WBVar00215120
      WBVar00215121
      WBVar02123883
      WBVar00215122
      WBVar00215123
      WBVar00215124
      WBVar00215125
      WBVar02045532
      WBVar01934081
      WBVar02035537
      WBVar00100750
      WBVar00100751
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (41)
    Paralog (31)
    Structured_description: Concise_description: ptc-3 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH(OMIM:601309, mutated in basal cell nevus syndrome), which defines oneof seven paralogous families of sterol sensing domain (SSD) proteins;PTC-3 is strongly required for normal molting from L1 to L3 larvalstages; PTC-3 is also required for normal growth to full size and forviability. Paper_evidence: WBPaper00004265
            WBPaper00026841
            WBPaper00027263
          Curator_confirmed: WBPerson567
          Date_last_updated: 08 Nov 2006 00:00:00
      Automated_description: Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in molting cycle. Located in apical plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CEP; cloaca; egg-laying apparatus; excretory duct; and preanal ganglion. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal adenoma; and holoprosencephaly 7. Is an ortholog of human PTCH1 (patched 1) and PTCH2 (patched 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (18)
  Molecular_info: Corresponding_CDS: Y110A2AL.8a
      Y110A2AL.8b
      Y110A2AL.8c
    Corresponding_CDS_history: Y110A2AL.8a:wp127
      Y110A2AL.8b:wp127
    Corresponding_transcript: Y110A2AL.8a.1
      Y110A2AL.8b.1
      Y110A2AL.8c.1
    Other_sequence: CRC01499_1
      JI466102.1
      FC542662.1
      RS10592
      Oden_isotig18879
      TSC10955_1
      HBC18725_1
      EX564995.1
      BMC12862_1
      Dviv_isotig06231
      CBC13056_1
      Dviv_isotig06232
      CR01496
      MAC02080_1
      BM00762
      MA01112
      EX501518.1
      Acan_isotig02692
      JI479119.1
      ES567197.1
      CR02074
      JI164462.1
      DN153091.1
      ACC30645_1
      RS06795
      RSC04460_1
      FC548736.1
      Dviv_contig12364
      FC549925.1
      MHC09340_1
      TSC07345_1
      ACC24546_1
      Acan_isotig02691
      CRC04917_1
    Associated_feature (13)
  Experimental_info: RNAi_result (14)
    Expr_pattern: Expr9231
      Expr9232
      Expr1017786
      Expr1032067
      Expr1158842
      Expr2015145
      Expr2033383
    Drives_construct: WBCnstr00008494
      WBCnstr00008496
      WBCnstr00035634
    Construct_product: WBCnstr00008494
      WBCnstr00008495
      WBCnstr00008496
      WBCnstr00008497
      WBCnstr00008498
      WBCnstr00008502
      WBCnstr00035634
    Antibody: WBAntibody00002998
    Microarray_results (31)
    Expression_cluster (200)
    Interaction (78)
    WBProcess: WBbiopr:00000123
  Map_info: Map: II Position: -9.82406 Error: 0.084736
    Positive: Positive_clone: Y110A2AL Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (21)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene