swsn-4 (phasmid socket absent) gene encodes an ortholog of SWI2/SNF2, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; swsn-4 is probably required during mitosis of the T cells for asymmetric cell division.
Predicted to enable ATP-dependent activity, acting on DNA and DNA binding activity. Involved in gonad development. Predicted to be located in nucleus. Expressed in several structures, including head; hyp7 syncytium; tail; ventral cord neurons; and vulval cell. Used to study alcohol use disorder and cancer. Human ortholog(s) of this gene implicated in several diseases, including Coffin-Siris syndrome 4; carcinoma (multiple); and rhabdoid cancer. Is an ortholog of human SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2) and SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4).
Sequence connection from [Goldstein B], [020620 krb]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.