WormBase Tree Display for Gene: WBGene00004166

WBGene00004166 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 3
    Name: CGC_name: scc-2
      Sequence_name: Y43H11AL.3
      Molecular_name: Y43H11AL.3a
        Y43H11AL.3a.1
        CE53800
        Y43H11AL.3b
        CE50846
        Y43H11AL.3a.2
        Y43H11AL.3b.1
      Other_name: Y43H11AL.a Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        Y43H11AL.b Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        Y43H11AL.e Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        Y43H11AL.f Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        pqn-85 Paper_evidence: WBPaper00040110
        CELE_Y43H11AL.3 Accession_evidence: NDB BX284602
      Public_name: scc-2
    DB_info: Database: AceView gene 2A532
        WormQTL gene WBGene00004166
        WormFlux gene WBGene00004166
        NDB locus_tag CELE_Y43H11AL.3
        Panther gene CAEEL|WormBase=WBGene00004166|UniProtKB=Q95XZ5
          family PTHR21704
        NCBI gene 173410
        RefSeq protein NM_001313675.3
            NM_001377684.4
        SwissProt UniProtAcc Q95XZ5
        UniProt_GCRP UniProtAcc Q95XZ5
        OMIM gene 608667
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 16 Feb 2021 13:27:21 WBPerson1983 Name_change: Other_name: scc-2
        3 11 Mar 2021 09:37:10 WBPerson1983 Name_change: CGC_name: scc-2
                Other_name: pqn-85
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: scc
    Allele: WBVar02148947
      WBVar00697602
      WBVar00697603
      WBVar00251175
      WBVar00697604
      WBVar00697605
      WBVar00697606
      WBVar00697607
      WBVar00697608
      WBVar01429656
      WBVar00697609
      WBVar00697610
      WBVar00697611
      WBVar00697612
      WBVar00697613
      WBVar00697614
      WBVar00697615
      WBVar00697616
      WBVar00697617
      WBVar02039839
      WBVar00697618
      WBVar02039840
      WBVar02039842
      WBVar00697619
      WBVar00697620
      WBVar02039843
      WBVar00697621
      WBVar00095683
      WBVar02006383
      WBVar00095684
      WBVar02006384
      WBVar00697622
      WBVar00697623
      WBVar02006385
      WBVar00697624
      WBVar02006387
      WBVar00697625
      WBVar02006388
      WBVar00259488
      WBVar00697626
      WBVar02006389
      WBVar00697627
      WBVar02006390
      WBVar00697628
      WBVar00697629
      WBVar00697630
      WBVar00697631
      WBVar00697632
      WBVar00697633
      WBVar00601265
      WBVar00697634
      WBVar00697635
      WBVar00697636
      WBVar01665158
      WBVar02093581
      WBVar00697637
      WBVar01237029
      WBVar00697638
      WBVar00697639
      WBVar00697640
      WBVar01500106
      WBVar01412414
      WBVar01412415
      WBVar00697641
      WBVar01412416
      WBVar02066919
      WBVar00697642
      WBVar00697643
      WBVar00697644
      WBVar00697645
      WBVar00697646
      WBVar00697647
      WBVar00143753
      WBVar00697648
      WBVar00697649
      WBVar00697650
      WBVar00697651
      WBVar00697652
      WBVar00697653
      WBVar00697654
      WBVar00697655
      WBVar00697656
      WBVar00697657
      WBVar00697658
      WBVar00697659
      WBVar00697660
      WBVar00697661
      WBVar00697662
      WBVar00697663
      WBVar00251235
      WBVar00697664
      WBVar00697665
      WBVar00697666
      WBVar01498661
      WBVar00697667
      WBVar00697668
      WBVar00251239
      WBVar00249394
      WBVar00697669
      WBVar00697670
      WBVar00697671
      WBVar00697672
      WBVar00697673
      WBVar00697674
      WBVar02098955
      WBVar00697675
      WBVar00697676
      WBVar01488917
      WBVar01681609
      WBVar00697677
      WBVar00354400
      WBVar01681610
      WBVar00697678
      WBVar00697679
      WBVar01681611
      WBVar00354401
      WBVar00354402
      WBVar01681612
      WBVar00697680
      WBVar00697681
      WBVar00354403
      WBVar01681613
      WBVar01681614
      WBVar00697682
      WBVar00354404
      WBVar00697683
      WBVar00354405
      WBVar01681615
      WBVar00697684
      WBVar00354406
      WBVar01681616
      WBVar00354407
      WBVar01681617
      WBVar00697685
      WBVar00354408
      WBVar01681618
      WBVar00697686
      WBVar00354409
      WBVar01681619
      WBVar00697687
      WBVar02002445
      WBVar01958925
      WBVar00354410
      WBVar00697688
      WBVar01681620
      WBVar00697689
      WBVar01958926
      WBVar00354411
      WBVar00697690
      WBVar00354412
      WBVar01291205
      WBVar00697691
      WBVar00354413
      WBVar00354414
      WBVar01291207
      WBVar00697692
      WBVar00697693
      WBVar01291208
      WBVar00354415
      WBVar00275656
      WBVar01291209
      WBVar00697694
      WBVar01476791
      WBVar00354416
      WBVar01291210
      WBVar00697695
      WBVar01476792
      WBVar00354417
      WBVar00697696
      WBVar00354418
      WBVar01476793
      WBVar01291212
      WBVar00354419
      WBVar01291213
      WBVar00697697
      WBVar01476794
      WBVar00354420
      WBVar01291214
      WBVar01476795
      WBVar00697698
      WBVar01476796
      WBVar01291215
      WBVar00697699
      WBVar00354421
      WBVar00354422
      WBVar01291216
      WBVar00697700
      WBVar00697701
      WBVar00543526
      WBVar01291218
      WBVar00354423
      WBVar00697702
      WBVar00543529
      WBVar00354424
      WBVar01291219
      WBVar00354425
      WBVar01291220
      WBVar00543531
      WBVar00697703
      WBVar01291222
      WBVar00543532
      WBVar00354426
      WBVar00697704
      WBVar00697705
      WBVar00354427
      WBVar01291223
      WBVar00354428
      WBVar00697706
      WBVar01291224
      WBVar01291225
      WBVar00697707
      WBVar00354429
      WBVar00354430
      WBVar00697708
      WBVar01291226
      WBVar00354431
      WBVar00697709
      WBVar01291227
      WBVar00354432
      WBVar00697710
      WBVar01291229
      WBVar00697711
      WBVar01291230
      WBVar00354433
      WBVar00697712
      WBVar01291231
      WBVar00354434
      WBVar00697713
      WBVar01291232
      WBVar00354435
      WBVar00354436
      WBVar00697714
      WBVar00697715
      WBVar00354437
      WBVar01532496
      WBVar00697716
      WBVar00354438
      WBVar00697717
      WBVar00354439
      WBVar00697718
      WBVar00354440
      WBVar00697719
      WBVar00354441
      WBVar00354442
      WBVar00697720
      WBVar01435243
      WBVar00354443
      WBVar00697721
      WBVar00697722
      WBVar01435244
      WBVar00354444
      WBVar00354445
      WBVar00697723
      WBVar01435245
      WBVar01435246
      WBVar00697724
      WBVar00354446
      WBVar01435247
      WBVar00697725
      WBVar00354447
      WBVar01435248
      WBVar00697726
      WBVar00354448
      WBVar01435250
      WBVar00354449
      WBVar00697727
      WBVar00697728
      WBVar00354450
      WBVar00354451
      WBVar00354452
      WBVar00354453
      WBVar02129205
      WBVar00354454
      WBVar02129206
      WBVar00354455
      WBVar00354456
      WBVar00354457
      WBVar01988581
      WBVar01988582
      WBVar01988583
      WBVar01358144
      WBVar00162892
      WBVar00162893
      WBVar01358156
      WBVar00162894
      WBVar01358167
      WBVar00162896
      WBVar00162898
      WBVar00162899
      WBVar01801426
      WBVar00162900
      WBVar01801427
      WBVar01623016
      WBVar00162901
      WBVar01801428
      WBVar00162902
      WBVar02017214
      WBVar01623017
      WBVar01623018
      WBVar01623019
      WBVar00009131
      WBVar00296988
      WBVar02014220
      WBVar00009136
      WBVar02075058
      WBVar02014221
      WBVar00697583
      WBVar00697584
      WBVar00697585
      WBVar00009141
      WBVar00697586
      WBVar00697587
      WBVar01715478
      WBVar01715479
      WBVar00009146
      WBVar00697588
      WBVar01715480
      WBVar00697589
      WBVar01715481
      WBVar00697590
      WBVar01715482
      WBVar00697591
      WBVar00697592
      WBVar01715483
      WBVar00697593
      WBVar01762465
      WBVar00009156
      WBVar00697594
      WBVar00697595
      WBVar00697596
      WBVar00697597
      WBVar00697598
      WBVar00697599
      WBVar00697600
      WBVar00697601
    RNASeq_FPKM (74)
    GO_annotation (27)
    Contained_in_operon: CEOP2016
    Ortholog (43)
    Structured_description: Concise_description: pqn-85 encodes an ortholog of budding yeast Scc2p, Drosophila NIPPED-B,and human NIPBL (OMIM:608667, mutated in Cornelia de Lange syndrome)that is required for resistance to double-stranded DNA breakage; PQN-85is also required, with MAU-2 and SCC-3, for normal chromosomesegregation and embryonic viability; pqn-85(RNAi) induceshypersensitivity to double-stranded breaks in DNA (manifested byabnormal sterility induced by ionizing radiation, cisplatin, orcamptothecin); pqn-85(RNAi) of early embryos produces lagging ofanaphase chromosomes and 100% embryonic lethality; pqn-85(RNAi) isphenotypically enhanced by joint RNAi with mau-2, and jointpqn-85/scc-3(RNAi) grossly deranges chromosomal segregation in earlyembryos; by orthology with NIPPED-B, PQN-85 might also enable regulatoryinteractions between promoters and distant enhancers by antagonizingSCC-3. Paper_evidence: WBPaper00005068
            WBPaper00012788
            WBPaper00012830
            WBPaper00012882
            WBPaper00012897
            WBPaper00013003
            WBPaper00027710
            WBPaper00027740
          Curator_confirmed: WBPerson567
          Date_last_updated: 25 Apr 2007 00:00:00
      Automated_description: Enables cohesin loader activity. Involved in several processes, including chromosome organization; double-strand break repair involved in meiotic recombination; and regulation of cell cycle process. Located in chromosome and nucleus. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 1. Is an ortholog of human NIPBL (NIPBL cohesin loading factor). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:11725 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:28862)
      DOID:0080505 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:28862)
  Molecular_info: Corresponding_CDS: Y43H11AL.3a
      Y43H11AL.3b
    Corresponding_CDS_history: Y43H11AL.3:wp112
      Y43H11AL.3a:wp274
    Corresponding_transcript: Y43H11AL.3a.1
      Y43H11AL.3a.2
      Y43H11AL.3b.1
    Other_sequence (15)
    Associated_feature (11)
  Experimental_info: RNAi_result (23)
    Expr_pattern: Expr1014154
      Expr1032031
      Expr1160014
      Expr2015077
      Expr2033313
    Antibody: WBAntibody00002289
    Microarray_results (25)
    Expression_cluster (123)
    Interaction: WBInteraction000036615
      WBInteraction000040815
      WBInteraction000521894
      WBInteraction000548804
      WBInteraction000548805
      WBInteraction000565533
      WBInteraction000575020
      WBInteraction000585366
  Map_info: Map: II Position: -15.7162 Error: 0.02322
    Positive: Positive_clone: Y43H11AL Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027710
    WBPaper00027740
    WBPaper00034662
    WBPaper00038432
    WBPaper00038491
    WBPaper00040110
    WBPaper00041549
    WBPaper00043670
    WBPaper00055090
    WBPaper00065958
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene