WormBase Tree Display for Gene: WBGene00004166
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| WBGene00004166 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | scc-2 | |||||||
| Sequence_name | Y43H11AL.3 | ||||||||
| Molecular_name | Y43H11AL.3a | ||||||||
| Y43H11AL.3a.1 | |||||||||
| CE53800 | |||||||||
| Y43H11AL.3b | |||||||||
| CE50846 | |||||||||
| Y43H11AL.3a.2 | |||||||||
| Y43H11AL.3b.1 | |||||||||
| Other_name | Y43H11AL.a | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| Y43H11AL.b | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| Y43H11AL.e | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| Y43H11AL.f | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| pqn-85 | Paper_evidence | WBPaper00040110 | |||||||
| CELE_Y43H11AL.3 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | scc-2 | ||||||||
| DB_info | Database | AceView | gene | 2A532 | |||||
| WormQTL | gene | WBGene00004166 | |||||||
| WormFlux | gene | WBGene00004166 | |||||||
| NDB | locus_tag | CELE_Y43H11AL.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004166|UniProtKB=Q95XZ5 | |||||||
| family | PTHR21704 | ||||||||
| NCBI | gene | 173410 | |||||||
| RefSeq | protein | NM_001313675.3 | |||||||
| NM_001377684.4 | |||||||||
| SwissProt | UniProtAcc | Q95XZ5 | |||||||
| UniProt_GCRP | UniProtAcc | Q95XZ5 | |||||||
| OMIM | gene | 608667 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 16 Feb 2021 13:27:21 | WBPerson1983 | Name_change | Other_name | scc-2 | ||||
| 3 | 11 Mar 2021 09:37:10 | WBPerson1983 | Name_change | CGC_name | scc-2 | ||||
| Other_name | pqn-85 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | scc | ||||||||
| Allele (335) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Contained_in_operon | CEOP2016 | ||||||||
| Ortholog (43) | |||||||||
| Structured_description | Concise_description | pqn-85 encodes an ortholog of budding yeast Scc2p, Drosophila NIPPED-B,and human NIPBL (OMIM:608667, mutated in Cornelia de Lange syndrome)that is required for resistance to double-stranded DNA breakage; PQN-85is also required, with MAU-2 and SCC-3, for normal chromosomesegregation and embryonic viability; pqn-85(RNAi) induceshypersensitivity to double-stranded breaks in DNA (manifested byabnormal sterility induced by ionizing radiation, cisplatin, orcamptothecin); pqn-85(RNAi) of early embryos produces lagging ofanaphase chromosomes and 100% embryonic lethality; pqn-85(RNAi) isphenotypically enhanced by joint RNAi with mau-2, and jointpqn-85/scc-3(RNAi) grossly deranges chromosomal segregation in earlyembryos; by orthology with NIPPED-B, PQN-85 might also enable regulatoryinteractions between promoters and distant enhancers by antagonizingSCC-3. | Paper_evidence | WBPaper00005068 | |||||
| WBPaper00012788 | |||||||||
| WBPaper00012830 | |||||||||
| WBPaper00012882 | |||||||||
| WBPaper00012897 | |||||||||
| WBPaper00013003 | |||||||||
| WBPaper00027710 | |||||||||
| WBPaper00027740 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 25 Apr 2007 00:00:00 | ||||||||
| Automated_description | Enables cohesin loader activity. Involved in several processes, including chromosome organization; double-strand break repair involved in meiotic recombination; and regulation of cell cycle process. Located in chromosome and nucleus. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 1. Is an ortholog of human NIPBL (NIPBL cohesin loading factor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:11725 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:28862) | ||||
| DOID:0080505 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:28862) | ||||||
| Molecular_info | Corresponding_CDS | Y43H11AL.3a | |||||||
| Y43H11AL.3b | |||||||||
| Corresponding_CDS_history | Y43H11AL.3:wp112 | ||||||||
| Y43H11AL.3a:wp274 | |||||||||
| Corresponding_transcript | Y43H11AL.3a.1 | ||||||||
| Y43H11AL.3a.2 | |||||||||
| Y43H11AL.3b.1 | |||||||||
| Other_sequence (15) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern | Expr1014154 | ||||||||
| Expr1032031 | |||||||||
| Expr1160014 | |||||||||
| Expr2015077 | |||||||||
| Expr2033313 | |||||||||
| Antibody | WBAntibody00002289 | ||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (123) | |||||||||
| Interaction | WBInteraction000036615 | ||||||||
| WBInteraction000040815 | |||||||||
| WBInteraction000521894 | |||||||||
| WBInteraction000548804 | |||||||||
| WBInteraction000548805 | |||||||||
| WBInteraction000565533 | |||||||||
| WBInteraction000575020 | |||||||||
| WBInteraction000585366 | |||||||||
| Map_info | Map | II | Position | -15.7162 | Error | 0.02322 | |||
| Positive | Positive_clone | Y43H11AL | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00027710 | ||||||||
| WBPaper00027740 | |||||||||
| WBPaper00034662 | |||||||||
| WBPaper00038432 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040110 | |||||||||
| WBPaper00041549 | |||||||||
| WBPaper00043670 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00065958 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
