WormBase Tree Display for Gene: WBGene00004092
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| WBGene00004092 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F44C4 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ppt-1 | |||||||
| Sequence_name | F44C4.5 | ||||||||
| Molecular_name | F44C4.5 | ||||||||
| F44C4.5.1 | |||||||||
| CE47017 | |||||||||
| Other_name | CELE_F44C4.5 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | ppt-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ppt | ||||||||
| Allele (29) | |||||||||
| Strain | WBStrain00026618 | ||||||||
| WBStrain00035551 | |||||||||
| WBStrain00035553 | |||||||||
| WBStrain00035567 | |||||||||
| WBStrain00035568 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (37) | |||||||||
| Structured_description | Concise_description | ppt-1 encodes the C. elegans palmitoyl protein thioesterase-1 ortholog; by homology PPT-1 is predicted to function in degradation of palmitoylated proteins and ppt-1 mutations result in loss of enzymatic activity from mixed-stage extracts; in C. elegans, ppt-1 activity is essential for mitochondrial organization and biogenesis in neuronal and muscle cells, as well as for proper timing of the onset of both the L4-to-adult molt and egg laying; ppt-1 is also required for normal egg-laying behavior and for a fully normal adult | Paper_evidence | WBPaper00025120 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 01 Sep 2006 00:00:00 | ||||||||
| Automated_description | Enables palmitoyl-(protein) hydrolase activity. Involved in several processes, including egg-laying behavior; mitochondrion organization; and protein catabolic process. Predicted to be located in lysosome. Used to study neuronal ceroid lipofuscinosis. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 1. Is an ortholog of human PPT1 (palmitoyl-protein thioesterase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14503 | Homo sapiens | Paper_evidence | WBPaper00025120 | ||||
| Accession_evidence | OMIM | 256730 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 15 May 2017 00:00:00 | ||||||||
| Potential_model | DOID:0110721 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9325) | |||||
| Disease_relevance | Mutations in human palmitoyl-protein thioesterase (PPT1), which is a small glycoprotein that removes palmitate groups from cysteine residues in lipid-modified proteins, have been implicated in neuronal ceroid lipofuscinosis. | Homo sapiens | Paper_evidence | WBPaper00025120 | |||||
| Accession_evidence | OMIM | 600722 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 15 May 2017 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000182 | ||||||||
| Molecular_info | Corresponding_CDS | F44C4.5 | |||||||
| Corresponding_CDS_history | F44C4.5:wp229 | ||||||||
| Corresponding_transcript | F44C4.5.1 | ||||||||
| Other_sequence (46) | |||||||||
| Associated_feature | WBsf652722 | ||||||||
| WBsf1000316 | |||||||||
| WBsf1019831 | |||||||||
| WBsf233839 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00032222 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00103724 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00047260 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103743 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00014912 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103712 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103734 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1027609 | ||||||||
| Expr1031976 | |||||||||
| Expr1151116 | |||||||||
| Expr2015022 | |||||||||
| Expr2033257 | |||||||||
| Drives_construct | WBCnstr00035704 | ||||||||
| Construct_product | WBCnstr00035704 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (171) | |||||||||
| Interaction | WBInteraction000237919 | ||||||||
| WBInteraction000258346 | |||||||||
| WBInteraction000332092 | |||||||||
| WBInteraction000348884 | |||||||||
| WBInteraction000350173 | |||||||||
| WBInteraction000414701 | |||||||||
| WBInteraction000416289 | |||||||||
| WBInteraction000421043 | |||||||||
| WBInteraction000461229 | |||||||||
| WBInteraction000521754 | |||||||||
| Map_info | Map | V | Position | 0.1242 | Error | 0.002992 | |||
| Positive | Positive_clone | F44C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4598 | |||||||
| 5361 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00025120 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00042257 | |||||||||
| WBPaper00042615 | |||||||||
| WBPaper00045834 | |||||||||
| WBPaper00053559 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | [Sara E Mole] Three C. elegans genes are equally similar to the human gene CLN3 which causes juvenile neuronal ceroid lipofuscinosis (NCL) or Batten disease. There is at least one similar gene in over 20 eukaryotic species, including S. cerevisiae, S.pombe, D. melanogaster. No other completely sequenced genome has more than one CLN3 homologue. All three cln-3 genes in C. elegans are trancribed and accession numbers have been applied for. In human there are up to 8 NCL genes named CLN-8. CLN1 also has one homologue in C. elegans. CLN1 encodes the enzyme palmitoyl protein thioesterase 1 (PPT1). | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
