WormBase Tree Display for Gene: WBGene00004078
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| WBGene00004078 | SMap | S_parent | Sequence | F52E1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pos-1 | Person_evidence | WBPerson419 | |||||
| Sequence_name | F52E1.1 | ||||||||
| Molecular_name | F52E1.1 | ||||||||
| F52E1.1.1 | |||||||||
| CE04629 | |||||||||
| Other_name | CELE_F52E1.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | pos-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pos | ||||||||
| Allele (25) | |||||||||
| Legacy_information | [Tabara H] Terminal stage pos-1 mutant embryos lack germ cell progenitors and intestine. ABp also produces pharynx. Maternal mRNA of pos-1 localizes into P-lineage. | ||||||||
| Strain | WBStrain00022471 | ||||||||
| WBStrain00005744 | |||||||||
| WBStrain00030276 | |||||||||
| WBStrain00022478 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (47) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | pos-1 encodes a CCCH-type zinc-finger protein; during embryogenesis, maternally provided POS-1 is essential for proper fate specification of germ cells, intestine, pharynx, and hypodermis; POS-1's role in cell fate specification is likely as a translational regulator, as POS-1 is required, in posterior blastomeres, for positive regulation of apx-1 mRNA translation and negative regulation of glp-1 mRNA translation via direct binding to the spatial control region (SCR) in the glp-1 mRNA 3' UTR; in regulating mRNA translation, POS-1 interacts with SPN-4, an RNP-type RNA binding protein, that may function to negatively regulate POS-1 activity; POS-1 can also bind the mex-6 3'-UTR in vitro, although expression of a MEX-6 reporter fusion protein does not appear to be affected in pos-1 mutant animals; pos-1 mRNA is first detected in the gonads of L4 and adult animals, and is present uniformly in oocytes and newly fertilized embryos; during early embryonic divisions, pos-1 mRNA is present at higher levels in germline blastomeres until it disappears following the division of P4; POS-1 protein is first apparent at low levels in 1-cell embryos, with subsequent expression mirroring that of pos-1 mRNA: high levels in germline blastomeres until its disappearance after the P4 division; in the germline blastomeres P1, P2, P3, and P4, POS-1 colocalizes with cytoplasmic and perinuclear P granules. | Paper_evidence | WBPaper00003382 | |||||
| WBPaper00005822 | |||||||||
| WBPaper00028569 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 09 Feb 2012 00:00:00 | ||||||||
| Automated_description | Enables mRNA 3'-UTR binding activity; poly(U) RNA binding activity; and transcription corepressor activity. Involved in several processes, including cell fate specification; embryonic pattern specification; and negative regulation of transcription by RNA polymerase II. Located in P granule. Expressed in several structures, including Psub4; germ line; neurons; oocyte; and rectal gland cell. Human ortholog(s) of this gene implicated in breast cancer. Is an ortholog of human ZFP36 (ZFP36 ring finger protein); ZFP36L1 (ZFP36 ring finger protein like 1); and ZFP36L2 (ZFP36 ring finger protein like 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12862) | ||||
| EFO:MONDO:0014769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1108) | ||||||
| Molecular_info | Corresponding_CDS | F52E1.1 | |||||||
| Corresponding_transcript | F52E1.1.1 | ||||||||
| Other_sequence (43) | |||||||||
| Associated_feature | WBsf977478 | ||||||||
| WBsf977479 | |||||||||
| WBsf977480 | |||||||||
| WBsf978729 | |||||||||
| WBsf232104 | |||||||||
| WBsf232105 | |||||||||
| Gene_product_binds | WBsf028078 | ||||||||
| WBsf034245 | |||||||||
| Transcription_factor | WBTranscriptionFactor000111 | ||||||||
| Experimental_info | RNAi_result (46) | ||||||||
| Expr_pattern (14) | |||||||||
| Drives_construct | WBCnstr00012723 | ||||||||
| WBCnstr00017949 | |||||||||
| WBCnstr00040853 | |||||||||
| WBCnstr00042916 | |||||||||
| Construct_product | WBCnstr00000085 | ||||||||
| WBCnstr00005587 | |||||||||
| WBCnstr00016851 | |||||||||
| WBCnstr00017949 | |||||||||
| WBCnstr00021253 | |||||||||
| WBCnstr00022630 | |||||||||
| Antibody | WBAntibody00000207 | ||||||||
| WBAntibody00000208 | |||||||||
| WBAntibody00000425 | |||||||||
| WBAntibody00001053 | |||||||||
| WBAntibody00001403 | |||||||||
| WBAntibody00001621 | |||||||||
| WBAntibody00001637 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (255) | |||||||||
| Interaction (331) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| Map_info | Map | V | Position | 1.40307 | Error | 0.003599 | |||
| Positive | Positive_clone | F52E1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4596 | |||||||
| Pseudo_map_position | |||||||||
| Reference (132) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
