WormBase Tree Display for Gene: WBGene00004048

WBGene00004048 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: K04B12
  Identity: Version: 1
    Name: CGC_name: plx-2 Person_evidence: WBPerson644
      Sequence_name: K04B12.1
      Molecular_name: K04B12.1
        K04B12.1.1
        CE53912
      Other_name: cep-1 Paper_evidence: WBPaper00018146
            WBPaper00023469
            WBPaper00011906
        CELE_K04B12.1 Accession_evidence: NDB BX284602
      Public_name: plx-2
    DB_info: Database: AceView gene 2O704
        WormQTL gene WBGene00004048
        WormFlux gene WBGene00004048
        NDB locus_tag CELE_K04B12.1
        Panther gene CAEEL|WormBase=WBGene00004048|UniProtKB=O45657
          family PTHR22625
        NCBI gene 175101
        RefSeq protein NM_001377900.1
        SwissProt UniProtAcc O45657
        UniProt_GCRP UniProtAcc O45657
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: plx
    Allele (139)
    Strain: WBStrain00029146
      WBStrain00029147
      WBStrain00029148
      WBStrain00029149
      WBStrain00030125
    RNASeq_FPKM (74)
    GO_annotation (30)
    Ortholog (31)
    Paralog: WBGene00004047 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: plx-2 encodes one of two C. elegans plexins, conserved transmembrane proteins that function as semaphorin receptors in both vertebrates and invertebrates; plx-2 activity is essential for proper male tail and epidermal morphogenesis and for normal axon guidance in a select group of neurons, including SDQL; genetic analyses indicate that plx-2 functions with mab-20/semaphorin-2a, efn-4/ephrin-4, and unc-129/TGF-beta to regulate male tail morphogenesis and with mab-20 and lad-2/L1CAM to mediate axon guidance; PLX-2 can bind MAB-20 and this interaction is enhanced in the presence of LAD-2; PLX-2::GFP reporters are expressed in a subset of neurons and epidermal cells, as well as a subset (1, 3, 5, and 7) of male sensory ray cell clusters. Paper_evidence: WBPaper00006490
            WBPaper00029396
            WBPaper00031430
          Curator_confirmed: WBPerson1843
          Date_last_updated: 23 Jul 2008 00:00:00
      Automated_description: Enables semaphorin receptor activity. Involved in several processes, including axonal fasciculation; nematode larval development; and nematode male tail tip morphogenesis. Located in cell leading edge and cell surface. Expressed in several structures, including P3/4L; P9/10L; P9/10R; neuroblasts; and ray structural cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K04B12.1
    Corresponding_CDS_history: K04B12.1:wp92
      K04B12.1:wp109
      K04B12.1:wp180
      K04B12.1:wp274
    Corresponding_transcript: K04B12.1.1
    Other_sequence: Dviv_isotig22187
      FC552303.1
      ACC17590_1
      FC551755.1
      JI164274.1
      Acan_isotig12889
      Dviv_isotig33737
      Dviv_isotig33915
      Oden_isotig23212
    Associated_feature (17)
  Experimental_info: RNAi_result: WBRNAi00065915 Inferred_automatically: RNAi_primary
      WBRNAi00016577 Inferred_automatically: RNAi_primary
      WBRNAi00049879 Inferred_automatically: RNAi_primary
      WBRNAi00000986 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2929
      Expr4682
      Expr10005
      Expr1023808
      Expr1031948
      Expr1153584
      Expr1200099
      Expr2014968
      Expr2033203
    Drives_construct (15)
    Construct_product: WBCnstr00000486
      WBCnstr00035722
    Microarray_results (21)
    Expression_cluster (209)
    Interaction (29)
    WBProcess: WBbiopr:00000025
  Map_info: Map: II Position: 22.9962 Error: 0.007199
    Positive: Positive_clone: K04B12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4590
    Pseudo_map_position
  Reference: WBPaper00004919
    WBPaper00005257
    WBPaper00006025
    WBPaper00006490
    WBPaper00010350
    WBPaper00010377
    WBPaper00010664
    WBPaper00011512
    WBPaper00016598
    WBPaper00016847
    WBPaper00017077
    WBPaper00017611
    WBPaper00017949
    WBPaper00018146
    WBPaper00018972
    WBPaper00019066
    WBPaper00019399
    WBPaper00019428
    WBPaper00019492
    WBPaper00019536
    WBPaper00019582
    WBPaper00023469
    WBPaper00023993
    WBPaper00024036
    WBPaper00024072
    WBPaper00024301
    WBPaper00024937
    WBPaper00024954
    WBPaper00025087
    WBPaper00025747
    WBPaper00025933
    WBPaper00025987
    WBPaper00026229
    WBPaper00026289
    WBPaper00026339
    WBPaper00026794
    WBPaper00027223
    WBPaper00027234
    WBPaper00027253
    WBPaper00027256
    WBPaper00027278
    WBPaper00027307
    WBPaper00027315
    WBPaper00027421
    WBPaper00027462
    WBPaper00027594
    WBPaper00028397
    WBPaper00029011
    WBPaper00029085
    WBPaper00029396
    WBPaper00030303
    WBPaper00030412
    WBPaper00030422
    WBPaper00030994
    WBPaper00031034
    WBPaper00031430
    WBPaper00031605
    WBPaper00031994
    WBPaper00032022
    WBPaper00032137
    WBPaper00032268
    WBPaper00032356
    WBPaper00033066
    WBPaper00033127
    WBPaper00033129
    WBPaper00033279
    WBPaper00033376
    WBPaper00033761
    WBPaper00033940
    WBPaper00033961
    WBPaper00033963
    WBPaper00034305
    WBPaper00034306
    WBPaper00034523
    WBPaper00034556
    WBPaper00034799
    WBPaper00034891
    WBPaper00036023
    WBPaper00036108
    WBPaper00036429
    WBPaper00036971
    WBPaper00038001
    WBPaper00038491
    WBPaper00038703
    WBPaper00038788
    WBPaper00038927
    WBPaper00039038
    WBPaper00039044
    WBPaper00039512
    WBPaper00039612
    WBPaper00040551
    WBPaper00040786
    WBPaper00040806
    WBPaper00041066
    WBPaper00041495
    WBPaper00041756
    WBPaper00042351
    WBPaper00042800
    WBPaper00043090
    WBPaper00043639
    WBPaper00043656
    WBPaper00043659
    WBPaper00043757
    WBPaper00044641
    WBPaper00044798
    WBPaper00044858
    WBPaper00044938
    WBPaper00044942
    WBPaper00045374
    WBPaper00045954
    WBPaper00046362
    WBPaper00047319
    WBPaper00047796
    WBPaper00048917
    WBPaper00049178
    WBPaper00049274
    WBPaper00049480
    WBPaper00049555
    WBPaper00050602
    WBPaper00052038
    WBPaper00053317
    WBPaper00054641
    WBPaper00054936
    WBPaper00055090
    WBPaper00055127
    WBPaper00055968
    WBPaper00056814
    WBPaper00056888
    WBPaper00057093
    WBPaper00057362
    WBPaper00059071
    WBPaper00059862
    WBPaper00060014
    WBPaper00060598
    WBPaper00060608
    WBPaper00060635
    WBPaper00060772
    WBPaper00060787
    WBPaper00061470
    WBPaper00061670
    WBPaper00062826
    WBPaper00062830
    WBPaper00063038
    WBPaper00063123
    WBPaper00063964
    WBPaper00064256
    WBPaper00065765
    WBPaper00065779
  Remark: Sequence connection from [Takagi S]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [wm99ab616], [wm2001p535], and [jwm2000ab65] used cep-1 as an unapproved name for CGC plx-2 (K04B12.1). The CGC cep-1 (F52B5.5) is a p53 homolog
  Method: Gene