WormBase Tree Display for Gene: WBGene00004036
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WBGene00004036 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | plc-1 | Person_evidence | WBPerson51 | |||||
WBPerson1983 | |||||||||
Sequence_name | F31B12.1 | ||||||||
Molecular_name (36) | |||||||||
Other_name | PLC210 | Paper_evidence (5) | |||||||
frm-9 | Curator_confirmed | WBPerson4025 | |||||||
CELE_F31B12.1 | Accession_evidence | NDB | BX284606 | ||||||
Public_name | plc-1 | ||||||||
DB_info | Database (14) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 20 May 2019 14:10:26 | WBPerson1983 | Name_change | CGC_name | plc-1 | ||||
Other_name | frm-9 | ||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | plc | ||||||||
Allele (621) | |||||||||
Strain | WBStrain00002612 | ||||||||
WBStrain00030932 | |||||||||
WBStrain00030933 | |||||||||
WBStrain00051732 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (25) | |||||||||
Ortholog (36) | |||||||||
Paralog | WBGene00001177 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00004045 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00004037 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00004039 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00004038 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | plc-1 encodes a predicted phospholipase C that affects fertility and possesses two functional domains not commonly seen in other phospholipases: a C-terminal Ras-associating domain with structural similarity to RalGDS and AF-6, and an N-terminal CDC25-like domain that possesses structural homology to guanine nucleotide exchange proteins for Ras. | Paper_evidence (2) | ||||||
Curator_confirmed | WBPerson48 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables GTPase inhibitor activity; phosphatidylinositol phospholipase C activity; and small GTPase binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process; defense response to Gram-positive bacterium; and positive regulation of protein import into nucleus. Expressed in excretory system; intestine; neurons; spermatheca; and vulva. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; nephrotic syndrome type 2; and nephrotic syndrome type 3. Is an ortholog of human PLCE1 (phospholipase C epsilon 1). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:3717 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17175) | ||||
DOID:0080379 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17175) | ||||||
DOID:1184 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17175) | ||||||
DOID:0080382 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17175) | ||||||
Molecular_info | Corresponding_CDS (12) | ||||||||
Corresponding_CDS_history | F31B12.1a:wp40 | ||||||||
F31B12.1b:wp40 | |||||||||
F31B12.1b:wp52 | |||||||||
Corresponding_transcript (12) | |||||||||
Other_sequence (49) | |||||||||
Associated_feature (13) | |||||||||
Experimental_info | RNAi_result (25) | ||||||||
Expr_pattern (11) | |||||||||
Drives_construct | WBCnstr00000769 | ||||||||
WBCnstr00003170 | |||||||||
WBCnstr00006426 | |||||||||
WBCnstr00018194 | |||||||||
WBCnstr00035730 | |||||||||
Construct_product | WBCnstr00006426 | ||||||||
WBCnstr00035730 | |||||||||
Microarray_results (85) | |||||||||
Expression_cluster (182) | |||||||||
Interaction (14) | |||||||||
WBProcess | WBbiopr:00000067 | ||||||||
Map_info | Map | X | Position | 2.53988 | Error | 0.004789 | |||
Positive | Positive_clone | F31B12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (40) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |