WormBase Tree Display for Gene: WBGene00004036
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WBGene00004036 | SMap | S_parent | Sequence | CHROMOSOME_X | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | plc-1 | Person_evidence | WBPerson51 | |||
WBPerson1983 | |||||||
Sequence_name | F31B12.1 | ||||||
Molecular_name (36) | |||||||
Other_name | PLC210 | Paper_evidence | WBPaper00003022 | ||||
WBPaper00003365 | |||||||
WBPaper00003875 | |||||||
WBPaper00003432 | |||||||
WBPaper00023291 | |||||||
frm-9 | Curator_confirmed | WBPerson4025 | |||||
CELE_F31B12.1 | Accession_evidence | NDB | BX284606 | ||||
Public_name | plc-1 | ||||||
DB_info | Database (14) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | plc | ||||||
Allele (621) | |||||||
Strain | WBStrain00002612 | ||||||
WBStrain00030932 | |||||||
WBStrain00030933 | |||||||
WBStrain00051732 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (25) | |||||||
Ortholog (36) | |||||||
Paralog | WBGene00001177 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00004045 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004037 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004039 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004038 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | plc-1 encodes a predicted phospholipase C that affects fertility and possesses two functional domains not commonly seen in other phospholipases: a C-terminal Ras-associating domain with structural similarity to RalGDS and AF-6, and an N-terminal CDC25-like domain that possesses structural homology to guanine nucleotide exchange proteins for Ras. | Paper_evidence | WBPaper00003022 | |||
WBPaper00023291 | |||||||
Curator_confirmed | WBPerson48 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables GTPase inhibitor activity; phosphatidylinositol phospholipase C activity; and small GTPase binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process; defense response to Gram-positive bacterium; and positive regulation of protein import into nucleus. Expressed in excretory system; intestine; neurons; spermatheca; and vulva. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; nephrotic syndrome type 2; and nephrotic syndrome type 3. Is an ortholog of human PLCE1 (phospholipase C epsilon 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:3717 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17175) | ||
DOID:0080379 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17175) | ||||
DOID:1184 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17175) | ||||
DOID:0080382 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17175) | ||||
Molecular_info | Corresponding_CDS (12) | ||||||
Corresponding_CDS_history | F31B12.1a:wp40 | ||||||
F31B12.1b:wp40 | |||||||
F31B12.1b:wp52 | |||||||
Corresponding_transcript (12) | |||||||
Other_sequence (49) | |||||||
Associated_feature (13) | |||||||
Experimental_info | RNAi_result (25) | ||||||
Expr_pattern (11) | |||||||
Drives_construct (5) | |||||||
Construct_product | WBCnstr00006426 | ||||||
WBCnstr00035730 | |||||||
Microarray_results (85) | |||||||
Expression_cluster (182) | |||||||
Interaction (14) | |||||||
WBProcess | WBbiopr:00000067 | ||||||
Map_info | Map | X | Position | 2.53988 | Error | 0.004789 | |
Positive | Positive_clone | F31B12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (40) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |