WormBase Tree Display for Gene: WBGene00004032
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| WBGene00004032 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | pkc-1 | Person_evidence | WBPerson1505 | |||||
| Sequence_name | F57F5.5 | ||||||||
| Molecular_name (11) | |||||||||
| Other_name | kin-13 | ||||||||
| ttx-4 | Person_evidence | WBPerson433 | |||||||
| CELE_F57F5.5 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | pkc-1 | ||||||||
| DB_info | Database (15) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 28 Jul 2005 11:55:35 | WBPerson2970 | Name_change | Other_name | ttx-4 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pkc | ||||||||
| Allele (284) | |||||||||
| Legacy_information | [C.elegansII] NMK CR#PKC1A sofar??? | ||||||||
| [C.elegansII] VNMK. Not located on physical map. Encodes kinases related to protein kinase C (PKC1A and PKC1B). Transcript from proximal promoter encodes 707aa PKC1B, antibody stains cell bodies and processes of ~75 sensory neurons. Transcription from distal promoter yields kup-1, PKC1A (SL2 transpliced, 763 aa (additional 56aa at N-term of PKC1B). B:A ratio ~40 in early development, unity in adults. [Land et al. 1994a; Land et al. 1994b; CR] | |||||||||
| Strain | WBStrain00023632 | ||||||||
| WBStrain00031494 | |||||||||
| WBStrain00021994 | |||||||||
| WBStrain00021992 | |||||||||
| WBStrain00021993 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (62) | |||||||||
| Contained_in_operon | CEOP5312 | ||||||||
| Ortholog (43) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages. | Paper_evidence | WBPaper00001919 | |||||
| WBPaper00005493 | |||||||||
| WBPaper00018062 | |||||||||
| WBPaper00019015 | |||||||||
| WBPaper00019386 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables protein kinase C activity. Involved in several processes, including nervous system process; regulation of presynaptic dense core granule exocytosis; and signaling. Located in cholinergic synapse and neuron projection. Expressed in ganglia; linker cell; and neurons. Human ortholog(s) of this gene implicated in cerebral infarction. Is an ortholog of human PRKCE (protein kinase C epsilon). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9403) | ||||
| Molecular_info | Corresponding_CDS | F57F5.5a | |||||||
| F57F5.5b | |||||||||
| F57F5.5c | |||||||||
| Corresponding_CDS_history | F57F5.5:wp63 | ||||||||
| Corresponding_transcript | F57F5.5a.1 | ||||||||
| F57F5.5a.2 | |||||||||
| F57F5.5a.3 | |||||||||
| F57F5.5b.1 | |||||||||
| F57F5.5c.1 | |||||||||
| Other_sequence (51) | |||||||||
| Associated_feature (20) | |||||||||
| Experimental_info | RNAi_result (28) | ||||||||
| Expr_pattern (14) | |||||||||
| Drives_construct | WBCnstr00010322 | ||||||||
| WBCnstr00011283 | |||||||||
| WBCnstr00012366 | |||||||||
| Construct_product | WBCnstr00001337 | ||||||||
| WBCnstr00009752 | |||||||||
| WBCnstr00010322 | |||||||||
| WBCnstr00011283 | |||||||||
| WBCnstr00011511 | |||||||||
| WBCnstr00040056 | |||||||||
| Antibody | WBAntibody00000080 | ||||||||
| Microarray_results (32) | |||||||||
| Expression_cluster (147) | |||||||||
| Interaction (110) | |||||||||
| WBProcess | WBbiopr:00000120 | ||||||||
| Map_info | Map | V | Position | 3.59318 | Error | 0.006692 | |||
| Positive | Positive_clone | F10C2 | |||||||
| F57F5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 4470 | |||||||
| 4586 | |||||||||
| 5713 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (102) | |||||||||
| Remark | Map is V. | ||||||||
| Sequence connection updated to F57F5.5 as previous sequence (F10C2.1) was merged into F57F5.5. [020620 krb] | |||||||||
| clone CR#PKC1A appears to be spuriously associated with F48E8 on LGIII [jah 040303][030407 ck1] | |||||||||
| Method | Gene |
