WormBase Tree Display for Gene: WBGene00004029

WBGene00004029 SMap: S_parent: Sequence: K09B11
  Identity: Version: 2
    Name: CGC_name: pik-1 Person_evidence: WBPerson1122
      Sequence_name: K09B11.1
      Molecular_name: K09B11.1a
        K09B11.1a.1
        CE31033
        K09B11.1b
        CE45959
        K09B11.1a.2
        K09B11.1b.1
        K09B11.1c
      Other_name: CELE_K09B11.1 Accession_evidence: NDB BX284604
      Public_name: pik-1
    DB_info: Database (15)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 15 Aug 2011 12:02:42 WBPerson4025 Event: Acquires_merge: WBGene00206467
      Acquires_merge: WBGene00206467
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pik
    Allele (149)
    RNASeq_FPKM (74)
    GO_annotation (22)
    Contained_in_operon: CEOP4552
    Ortholog (42)
    Paralog (12)
    Structured_description: Concise_description: The pik-1 gene encodes a pelle/IRAK kinase homolog that may be involved in apoptosis. Paper_evidence: WBPaper00004589
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in cellular response to lipopolysaccharide and signal transduction. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Expressed in RMGL; RMGR; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of musculoskeletal system (multiple); diffuse scleroderma; and melioidosis. Is an ortholog of human IRAK1 (interleukin 1 receptor associated kinase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17967)
      DOID:9008 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6112)
      DOID:7147 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6112)
      DOID:8893 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6112)
      DOID:399 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17020)
      DOID:2841 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17020)
      DOID:1580 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6112)
      DOID:1749 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6112)
      DOID:5052 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17020)
  Molecular_info: Corresponding_CDS: K09B11.1a
      K09B11.1b
    Corresponding_CDS_history: K09B11.1:wp80
    Corresponding_transcript: K09B11.1c
      K09B11.1a.1
      K09B11.1a.2
      K09B11.1b.1
    Other_sequence (35)
    Associated_feature: WBsf998403
      WBsf998404
  Experimental_info: RNAi_result: WBRNAi00112978 Inferred_automatically: RNAi_primary
      WBRNAi00016868 Inferred_automatically: RNAi_primary
      WBRNAi00113208 Inferred_automatically: RNAi_primary
      WBRNAi00034179 Inferred_automatically: RNAi_primary
      WBRNAi00075962 Inferred_automatically: RNAi_primary
      WBRNAi00050370 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr13217
      Expr1010645
      Expr1031931
      Expr1154076
      Expr2014927
      Expr2033162
    Drives_construct: WBCnstr00038894
    Construct_product: WBCnstr00038894
    Microarray_results (22)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032528:L3_depleted
      WBPaper00037950:all-neurons_embryo_enriched
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045521:Gender_Neutral
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_upregulated_ClassI
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00055334:DLC-1_interacting
      WBPaper00055648:germline_expressed
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061340:AIN_parent
      WBPaper00061340:AMso_parent
      WBPaper00061340:K_Kprime
      WBPaper00061340:Neuroblast_ADF_AWB
      WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061527:176662_at-Y53F4B.16
      WBPaper00061613:human-amyloid-beta_upregulated
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062146:MOG-7-degron_1h_regulated
      WBPaper00062146:MOG-7-degron_2h_regulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00035479:daf-16(RNAi)_upregulated
      WBPaper00036286:Pattern_H
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00055899:nitroguanidine_regulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (320)
    WBProcess: WBbiopr:00000039
  Map_info: Map: IV Position: 9.21545 Error: 0.07179
    Positive: Positive_clone: K09B11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4585
        4914
    Pseudo_map_position
  Reference (14)
  Remark: Sequence given as K09B11 BUT subsequence not given [sdm]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene