WormBase Tree Display for Gene: WBGene00004002

WBGene00004002 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: pgp-8 Person_evidence: WBPerson490
      Sequence_name: T21E8.3
      Molecular_name: T21E8.3
        T21E8.3.1
        CE31624
      Other_name: CELE_T21E8.3 Accession_evidence: NDB BX284606
      Public_name: pgp-8
    DB_info: Database: AceView gene XL480
        WormQTL gene WBGene00004002
        WormFlux gene WBGene00004002
        NDB locus_tag CELE_T21E8.3
        Panther gene CAEEL|WormBase=WBGene00004002|UniProtKB=G5EG03
          family PTHR24221
        NCBI gene 181277
        RefSeq protein NM_077410.6
        TrEMBL UniProtAcc G5EG03
        UniProt_GCRP UniProtAcc G5EG03
        OMIM gene 171050
            171060
            603201
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pgp
    Allele (100)
    Strain: WBStrain00001121
      WBStrain00032601
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog: WBGene00023572 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00023573 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00023575 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00023577 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00026762 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00028069 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00033821 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00034135 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00034271 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037005 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037006 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037161 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00037162 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
      WBGene00037165 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00193770 Caenorhabditis brenneri From_analysis: TreeFam
      CBOVI.g3553 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP29.g15954 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g18380 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g18381 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP38.g18701 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      Cang_2012_03_13_00373.g9936 Caenorhabditis angaria From_analysis: WormBase-Compara
      Csp11.Scaffold629.g13816 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02403 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02473 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g04111 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g11889 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g603 Panagrellus redivivus From_analysis: WormBase-Compara
      chrX_pilon.g19956 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00256217 Strongyloides ratti From_analysis: WormBase-Compara
      SGD:S000001692 Saccharomyces cerevisiae From_analysis: Inparanoid
            OrthoInspector
            PhylomeDB
            SonicParanoid
      FB:FBgn0004512 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Panther
            PhylomeDB
      FB:FBgn0010241 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      FB:FBgn0035695 Drosophila melanogaster From_analysis: OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0004513 Drosophila melanogaster From_analysis: OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-050517-14 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      ZFIN:ZDB-GENE-030131-6414 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      ZFIN:ZDB-GENE-080204-52 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      HGNC:40 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      HGNC:45 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      HGNC:42 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      HGNC:46 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      MGI:97568 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      MGI:97569 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      MGI:97570 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      MGI:1351619 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      MGI:1924956 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      RGD:3318 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      RGD:620248 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      RGD:619930 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      RGD:1566342 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
    Paralog (23)
    Structured_description: Concise_description: pgp-8 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-8 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-8 activity via RNAi results in no obvious defects, the precise role of PGP-8 in C. elegans development and/or behavior is not yet known; pgp-8 promoter-gfp fusion proteins are expressed in adult head neurons. Paper_evidence: WBPaper00006421
            WBPaper00024561
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 07 Mar 2006 00:00:00
      Automated_description: Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Expressed in head neurons. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (41)
  Molecular_info: Corresponding_CDS: T21E8.3
    Corresponding_CDS_history: T21E8.3:wp83
    Corresponding_transcript: T21E8.3.1
    Other_sequence: HC05950
      HCC00124_1
      SSC04460_1
      SS02645
      FC544610.1
    Associated_feature (2)
  Experimental_info: RNAi_result: WBRNAi00053751 Inferred_automatically: RNAi_primary
      WBRNAi00035767 Inferred_automatically: RNAi_primary
      WBRNAi00077358 Inferred_automatically: RNAi_primary
      WBRNAi00070100 Inferred_automatically: RNAi_primary
      WBRNAi00018984 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1650
      Expr3333
      Expr3334
      Expr1017136
      Expr1157298
      Expr2014875
      Expr2033110
    Drives_construct: WBCnstr00002004
      WBCnstr00011329
      WBCnstr00011330
      WBCnstr00035748
    Construct_product: WBCnstr00016458
      WBCnstr00035748
    Microarray_results (18)
    Expression_cluster (206)
    Interaction (133)
  Map_info: Map: X Position: 2.59416 Error: 0.011138
    Positive: Positive_clone: T21E8 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00006402
    WBPaper00006421
    WBPaper00028970
    WBPaper00031023
    WBPaper00035429
    WBPaper00038491
    WBPaper00046184
    WBPaper00055090
    WBPaper00062515
    WBPaper00064375
  Remark: Sequence connection from [Sheps JA, Baillie DL] [040902 ck1]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene