WormBase Tree Display for Gene: WBGene00003995
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| WBGene00003995 | SMap | S_parent | Sequence | K08E7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pgp-1 | Person_evidence | WBPerson490 | |||||
| Sequence_name | K08E7.9 | ||||||||
| Molecular_name | K08E7.9 | ||||||||
| K08E7.9.1 | |||||||||
| CE11932 | |||||||||
| Other_name | cepgpA | Accession_evidence | EMBL | X65054 | |||||
| CELE_K08E7.9 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | pgp-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pgp | ||||||||
| Allele (118) | |||||||||
| Legacy_information | [C.elegansII] pk17 : deletion derived from pk28tci, no apparent drug sensitivity or other phenotype. Cloned: encodes 1321 aa P-glycoprotein, 61-65% identical to mammalian P-glycoproteins.Transcripts relatively low, peak early;pgp-1:lacZ expressed in intestine, throughout development. Tagged PGP-1 detected in gut apical membrane. [Broeks et al. 1995; NL] | ||||||||
| Strain | WBStrain00028887 | ||||||||
| WBStrain00028889 | |||||||||
| WBStrain00028891 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (64) | |||||||||
| Paralog (23) | |||||||||
| Structured_description | Concise_description | pgp-1 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; along with PGP-3, PGP-1 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-1 is expressed in the apical membrane of intestinal cells and in the intestinal valve cells. | Paper_evidence | WBPaper00002180 | |||||
| WBPaper00003366 | |||||||||
| WBPaper00003925 | |||||||||
| WBPaper00005654 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in defense response to other organism; response to metal ion; and response to nematicide. Located in apical plasma membrane. Expressed in intestinal cell; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (41) | ||||||||
| Molecular_info (4) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00070104 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00016820 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085165 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050311 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085169 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091137 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085175 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr710 | ||||||||
| Expr1546 | |||||||||
| Expr1548 | |||||||||
| Expr3339 | |||||||||
| Expr12394 | |||||||||
| Expr1021232 | |||||||||
| Expr1031911 | |||||||||
| Expr1154012 | |||||||||
| Expr2014868 | |||||||||
| Expr2033103 | |||||||||
| Drives_construct | WBCnstr00010330 | ||||||||
| WBCnstr00011335 | |||||||||
| WBCnstr00012502 | |||||||||
| WBCnstr00017594 | |||||||||
| WBCnstr00017595 | |||||||||
| WBCnstr00019886 | |||||||||
| WBCnstr00035755 | |||||||||
| Construct_product | WBCnstr00007868 | ||||||||
| WBCnstr00007870 | |||||||||
| WBCnstr00007871 | |||||||||
| WBCnstr00019886 | |||||||||
| WBCnstr00035755 | |||||||||
| Antibody | WBAntibody00000095 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (314) | |||||||||
| Interaction | WBInteraction000122582 | ||||||||
| WBInteraction000122808 | |||||||||
| WBInteraction000123089 | |||||||||
| WBInteraction000126398 | |||||||||
| WBInteraction000133028 | |||||||||
| WBInteraction000133042 | |||||||||
| WBInteraction000135484 | |||||||||
| WBInteraction000138046 | |||||||||
| WBInteraction000138050 | |||||||||
| WBInteraction000138052 | |||||||||
| WBInteraction000139920 | |||||||||
| WBInteraction000144990 | |||||||||
| WBInteraction000149872 | |||||||||
| WBInteraction000163621 | |||||||||
| WBInteraction000168177 | |||||||||
| WBInteraction000169569 | |||||||||
| WBInteraction000179328 | |||||||||
| WBInteraction000190908 | |||||||||
| WBInteraction000191403 | |||||||||
| WBInteraction000207934 | |||||||||
| WBInteraction000213080 | |||||||||
| WBInteraction000237031 | |||||||||
| WBInteraction000240322 | |||||||||
| WBInteraction000242842 | |||||||||
| WBInteraction000251531 | |||||||||
| WBInteraction000271506 | |||||||||
| WBInteraction000280709 | |||||||||
| WBInteraction000290238 | |||||||||
| WBInteraction000298879 | |||||||||
| WBInteraction000304277 | |||||||||
| WBInteraction000310789 | |||||||||
| WBInteraction000313886 | |||||||||
| WBInteraction000318268 | |||||||||
| WBInteraction000325171 | |||||||||
| WBInteraction000335940 | |||||||||
| WBInteraction000335942 | |||||||||
| WBInteraction000393536 | |||||||||
| WBInteraction000395468 | |||||||||
| WBInteraction000437356 | |||||||||
| WBInteraction000439224 | |||||||||
| WBInteraction000439225 | |||||||||
| WBInteraction000439226 | |||||||||
| WBInteraction000444489 | |||||||||
| WBInteraction000459544 | |||||||||
| WBInteraction000465752 | |||||||||
| WBInteraction000466812 | |||||||||
| WBInteraction000467404 | |||||||||
| WBInteraction000468035 | |||||||||
| WBInteraction000468870 | |||||||||
| WBInteraction000471103 | |||||||||
| WBInteraction000473069 | |||||||||
| WBInteraction000474320 | |||||||||
| WBInteraction000474833 | |||||||||
| WBInteraction000474834 | |||||||||
| WBInteraction000504800 | |||||||||
| WBInteraction000524442 | |||||||||
| WBInteraction000525280 | |||||||||
| WBInteraction000536776 | |||||||||
| WBInteraction000541242 | |||||||||
| WBInteraction000571190 | |||||||||
| WBInteraction000580241 | |||||||||
| WBInteraction000583079 | |||||||||
| WBInteraction000585880 | |||||||||
| WBProcess | WBbiopr:00000096 | ||||||||
| Map_info | Map | IV | Position | 6.0845 | Error | 0.005937 | |||
| Positive | Positive_clone | K08E7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| PB#CPG10 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (45) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
