pcs-1 encodes a phytochelatin synthase; PCS-1 exhibits cadmium-activated synthesis of phytochelatins, peptides with the general structure (gamma-Glu-Cys)n-Xaa that sequester heavy metals, and is required in animals for the response to, and detoxification of cadmium; when expressed in yeast, PCS-1 also mediates the detoxification of mercury and arsenic.
Enables glutathione gamma-glutamylcysteinyltransferase activity. Involved in phytochelatin biosynthetic process and response to metal ion. Expressed in several structures, including coelomocyte; non-striated muscle; pharyngeal-intestinal valve; pharynx; and rectal valve cell.
Sequence connection from [Vatamaniuk OK, Bucher EA]. krb 13/11/01
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.