WormBase Tree Display for Gene: WBGene00003955
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| WBGene00003955 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_IV | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | pcn-1 | Person_evidence | WBPerson1551 | |||||
| Sequence_name | W03D2.4 | ||||||||
| Molecular_name | W03D2.4 | ||||||||
| W03D2.4.1 | |||||||||
| CE14512 | |||||||||
| Other_name | CELE_W03D2.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | pcn-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pcn | ||||||||
| Allele (32) | |||||||||
| Strain | WBStrain00036585 | ||||||||
| WBStrain00047706 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (44) | |||||||||
| Structured_description | Concise_description | pcn-1 encodes the C. elegans ortholog of proliferating cell nuclear antigen (PCNA), an acidic protein that is an essential component of the DNA replication and repair machinery and serves as a processivity factor for DNA polymerase delta; PCN-1 is required for early embryogenesis and for proper germ-line development, and directly interacts with CKI-2, a cyclin-dependent kinase inhibitor homolog that may be required for cell cycle progression during embryogenesis, and with ATL-1/PI3K, KIN-20, MRT-2/RAD1, and RFC-1, proteins that all play a role in the DNA damage checkpoint pathway; PCN-1 is highly expressed in ovaries and developing embryos. | Paper_evidence | WBPaper00004540 | |||||
| WBPaper00005039 | |||||||||
| WBPaper00018634 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables DNA polymerase binding activity. Predicted to be involved in leading strand elongation; mismatch repair; and translesion synthesis. Predicted to be located in nucleus. Predicted to be part of PCNA complex. Human ortholog(s) of this gene implicated in several diseases, including Lewy body dementia; invasive ductal carcinoma; and kidney cancer (multiple). Is an ortholog of human PCNA (proliferating cell nuclear antigen). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2154 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8729) | ||||
| DOID:3008 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8729) | ||||||
| DOID:127 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8729) | ||||||
| DOID:0081385 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8729) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8729) | ||||||
| DOID:12217 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8729) | ||||||
| DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8729) | ||||||
| DOID:4440 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8729) | ||||||
| Molecular_info | Corresponding_CDS | W03D2.4 | |||||||
| Corresponding_CDS_history | W03D2.4:wp134 | ||||||||
| W03D2.4:wp203 | |||||||||
| Corresponding_transcript | W03D2.4.1 | ||||||||
| Other_sequence (33) | |||||||||
| Associated_feature | WBsf651719 | ||||||||
| WBsf977079 | |||||||||
| WBsf977080 | |||||||||
| WBsf977081 | |||||||||
| WBsf977082 | |||||||||
| WBsf981731 | |||||||||
| WBsf996166 | |||||||||
| WBsf229942 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00085676 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00054674 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007524 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106605 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106680 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091559 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr13737 | ||||||||
| Expr1021605 | |||||||||
| Expr1031881 | |||||||||
| Expr1158214 | |||||||||
| Expr2014782 | |||||||||
| Expr2033016 | |||||||||
| Drives_construct | WBCnstr00035777 | ||||||||
| Construct_product | WBCnstr00035777 | ||||||||
| Antibody | WBAntibody00001310 | ||||||||
| WBAntibody00002559 | |||||||||
| WBAntibody00002560 | |||||||||
| WBAntibody00002742 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (234) | |||||||||
| Interaction (403) | |||||||||
| Map_info | Map | IV | Position | -0.966799 | Error | 0.019425 | |||
| Positive | Positive_clone | W03D2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (23) | |||||||||
| Remark | Sequence connection from [Boulton S, Vidal M] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
