WormBase Tree Display for Gene: WBGene00003911
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| WBGene00003911 | SMap | S_parent | Sequence | C09B8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pak-1 | Person_evidence | WBPerson516 | |||||
| Sequence_name | C09B8.7 | ||||||||
| Molecular_name | C09B8.7a | ||||||||
| C09B8.7a.1 | |||||||||
| CE27670 | |||||||||
| C09B8.7b | |||||||||
| CE06792 | |||||||||
| C09B8.7c | |||||||||
| CE33559 | |||||||||
| C09B8.7b.1 | |||||||||
| C09B8.7c.1 | |||||||||
| Other_name | CePAK | ||||||||
| CELE_C09B8.7 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | pak-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pak | ||||||||
| Allele (77) | |||||||||
| Strain | WBStrain00031427 | ||||||||
| WBStrain00000137 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (49) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (27) | |||||||||
| Structured_description | Concise_description | pak-1 encodes, by alternative splicing, at least five isoforms of aputative p21-activated kinase orthologous to human PAK1, PAK2 (OMIM:?),and PAK3 (OMIM:300142, mutated in nonsyndromic mental retardation);PAK-1 is required (redundantly with its paralog, MAX-2) for normalaxonal guidance of motoneurons, P cell migration, and locomotion, withmax-2(cy2);pak-1(ok448) double mutants phenotypically resembling unc-73or ced-10;mig-2 mutants; pak-1 is expressed in pharyngeal muscles, CANneurons, ventral cord motoneurons, migrating distal tip cells,developing uterus, B, Y, and T cells in the male tail, and vulval musclecells; by itself, the null pak-1(ok448) mutation has no known phenotype. | Paper_evidence | WBPaper00003060 | |||||
| WBPaper00028729 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 31 Jan 2007 00:00:00 | ||||||||
| Automated_description | Enables GTP binding activity and protein kinase activity. Involved in several processes, including anatomical structure morphogenesis; hemidesmosome assembly; and inductive cell migration. Located in several cellular components, including axon; hemidesmosome; and neuronal cell body. Expressed in several structures, including P5.p hermaphrodite; P7.p hermaphrodite; gonad; hypodermis; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); kidney cancer (multiple); and non-syndromic X-linked intellectual disability 30. Is an ortholog of human PAK1 (p21 (RAC1) activated kinase 1); PAK2 (p21 (RAC1) activated kinase 2); and PAK3 (p21 (RAC1) activated kinase 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8590) | ||||
| DOID:2154 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8590) | ||||||
| DOID:0112051 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8592) | ||||||
| DOID:2671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8590) | ||||||
| DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8590) | ||||||
| DOID:0060074 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8591) | ||||||
| EFO:MONDO:0800166 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8591) | ||||||
| DOID:4001 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8590) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8590) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8590) | ||||||
| Molecular_info | Corresponding_CDS | C09B8.7a | |||||||
| C09B8.7b | |||||||||
| C09B8.7c | |||||||||
| Corresponding_CDS_history | C09B8.7d:wp135 | ||||||||
| C09B8.7e:wp275 | |||||||||
| Corresponding_transcript | C09B8.7a.1 | ||||||||
| C09B8.7b.1 | |||||||||
| C09B8.7c.1 | |||||||||
| Other_sequence (45) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00005467 | ||||||||
| WBCnstr00008104 | |||||||||
| WBCnstr00012501 | |||||||||
| WBCnstr00015511 | |||||||||
| WBCnstr00018256 | |||||||||
| WBCnstr00035801 | |||||||||
| WBCnstr00041561 | |||||||||
| Construct_product | WBCnstr00008104 | ||||||||
| WBCnstr00012501 | |||||||||
| WBCnstr00015511 | |||||||||
| WBCnstr00018885 | |||||||||
| WBCnstr00035801 | |||||||||
| WBCnstr00041561 | |||||||||
| Antibody | WBAntibody00000121 | ||||||||
| Microarray_results (37) | |||||||||
| Expression_cluster (124) | |||||||||
| Interaction (222) | |||||||||
| Map_info | Map | X | Position | -3.80222 | Error | 0.008236 | |||
| Positive | Positive_clone | C09B8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4344 | |||||||
| 4562 | |||||||||
| 5639 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (60) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
