pak-1 encodes, by alternative splicing, at least five isoforms of aputative p21-activated kinase orthologous to human PAK1, PAK2 (OMIM:?),and PAK3 (OMIM:300142, mutated in nonsyndromic mental retardation);PAK-1 is required (redundantly with its paralog, MAX-2) for normalaxonal guidance of motoneurons, P cell migration, and locomotion, withmax-2(cy2);pak-1(ok448) double mutants phenotypically resembling unc-73or ced-10;mig-2 mutants; pak-1 is expressed in pharyngeal muscles, CANneurons, ventral cord motoneurons, migrating distal tip cells,developing uterus, B, Y, and T cells in the male tail, and vulval musclecells; by itself, the null pak-1(ok448) mutation has no known phenotype.
Enables GTP binding activity and protein kinase activity. Involved in several processes, including anatomical structure morphogenesis; hemidesmosome assembly; and inductive cell migration. Located in several cellular components, including axon; hemidesmosome; and neuronal cell body. Expressed in several structures, including P5.p hermaphrodite; P7.p hermaphrodite; gonad; hypodermis; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); kidney cancer (multiple); and non-syndromic X-linked intellectual disability 30. Is an ortholog of human PAK1 (p21 (RAC1) activated kinase 1); PAK2 (p21 (RAC1) activated kinase 2); and PAK3 (p21 (RAC1) activated kinase 3).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.