WormBase Tree Display for Gene: WBGene00003909
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| WBGene00003909 | SMap | S_parent | Sequence | F45B8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pag-3 | |||||||
| Sequence_name | F45B8.4 | ||||||||
| Molecular_name | F45B8.4 | ||||||||
| F45B8.4.1 | |||||||||
| CE24977 | |||||||||
| Other_name | CELE_F45B8.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | pag-3 | ||||||||
| DB_info | Database | AceView | gene | XP570 | |||||
| WormQTL | gene | WBGene00003909 | |||||||
| WormFlux | gene | WBGene00003909 | |||||||
| NDB | locus_tag | CELE_F45B8.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003909|UniProtKB=G5EDE1 | |||||||
| family | PTHR24390 | ||||||||
| NCBI | gene | 181588 | |||||||
| RefSeq | protein | NM_078079.6 | |||||||
| SwissProt | UniProtAcc | G5EDE1 | |||||||
| TREEFAM | TREEFAM_ID | TF317208 | |||||||
| UniProt_GCRP | UniProtAcc | G5EDE1 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pag | ||||||||
| Allele | WBVar00088519 | Inferred_automatically | From strain object: EA81 | ||||||
| WBVar00088521 | |||||||||
| WBVar00088520 | |||||||||
| WBVar01499887 | |||||||||
| WBVar01499519 | |||||||||
| WBVar01499888 | |||||||||
| WBVar00102104 | |||||||||
| WBVar00102105 | |||||||||
| WBVar00237446 | |||||||||
| WBVar01499710 | |||||||||
| WBVar01942263 | |||||||||
| WBVar01211685 | |||||||||
| WBVar01211686 | |||||||||
| WBVar01211687 | |||||||||
| WBVar01211688 | |||||||||
| WBVar01211689 | |||||||||
| WBVar01211690 | |||||||||
| WBVar01211691 | |||||||||
| WBVar01211692 | |||||||||
| WBVar01211693 | |||||||||
| WBVar01211694 | |||||||||
| WBVar01211695 | |||||||||
| WBVar01211696 | |||||||||
| WBVar01211697 | |||||||||
| WBVar01211698 | |||||||||
| WBVar01211699 | |||||||||
| WBVar01211700 | |||||||||
| WBVar01211701 | |||||||||
| WBVar01528193 | |||||||||
| WBVar01211702 | |||||||||
| WBVar01211703 | |||||||||
| WBVar01211704 | |||||||||
| WBVar01211705 | |||||||||
| WBVar01211706 | |||||||||
| WBVar01211707 | |||||||||
| WBVar01211708 | |||||||||
| WBVar01211709 | |||||||||
| WBVar01211710 | |||||||||
| WBVar01211711 | |||||||||
| WBVar01211712 | |||||||||
| WBVar01211713 | |||||||||
| WBVar00525499 | |||||||||
| WBVar01211714 | |||||||||
| WBVar00525500 | |||||||||
| WBVar01211715 | |||||||||
| WBVar00525501 | |||||||||
| WBVar00525502 | |||||||||
| WBVar00090662 | |||||||||
| WBVar01211716 | |||||||||
| WBVar01211717 | |||||||||
| WBVar00525503 | |||||||||
| WBVar00525504 | |||||||||
| WBVar01211718 | |||||||||
| WBVar01211719 | |||||||||
| WBVar00525505 | |||||||||
| WBVar00525506 | |||||||||
| WBVar01211720 | |||||||||
| WBVar00525507 | |||||||||
| WBVar01211721 | |||||||||
| WBVar00525508 | |||||||||
| WBVar01211722 | |||||||||
| WBVar00525509 | |||||||||
| WBVar01211723 | |||||||||
| WBVar00525510 | |||||||||
| WBVar01928689 | |||||||||
| WBVar01928690 | |||||||||
| WBVar01928691 | |||||||||
| WBVar01788247 | |||||||||
| WBVar01545067 | |||||||||
| WBVar00278478 | |||||||||
| WBVar01497222 | |||||||||
| WBVar01830911 | |||||||||
| WBVar00087970 | |||||||||
| WBVar00085842 | |||||||||
| WBVar00085843 | |||||||||
| WBVar00085844 | |||||||||
| WBVar02051115 | |||||||||
| WBVar00091776 | |||||||||
| WBVar00218879 | |||||||||
| WBVar00258538 | |||||||||
| WBVar01498960 | |||||||||
| WBVar01500067 | |||||||||
| Legacy_information | [Aamodt EJ, Jia Y] ls20 causes misexpression of the mec-7 gene, mec-7lacZ and mec-4lacZ fusion genes in the BDU neurons. Also causes a reverse kinker uncoordinated phenotype, and occasional axonal guidance errors in the PLM and BDU neurons. NA1. | ||||||||
| [C.elegansII] ls20 : homozygotes exhibit misexpression of the mec-7 gene, mec-7lacZ and mec-4lacZ fusion genes in the BDU neurons. Also causes a reverse kinker uncoordinated phenotype, and occasional axonal guidance errors in the PLM and BDU neurons. NA1. [EA] | |||||||||
| [Aamodt EJ] predicted gene F45B8.4 | |||||||||
| Strain | WBStrain00027353 | ||||||||
| WBStrain00035715 | |||||||||
| WBStrain00006454 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00012639 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00017430 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00009937 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00022762 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00015138 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00009508 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | pag-3 encodes a C2H2 zinc-finger protein orthologous to DrosophilaSENSELESS, and to human GFI1 (OMIM:600871, mutated in neutropenia) andGFI1B (OMIM:604383); pag-3 is expressed in neurons (touch receptors, BDUinterneurons, ventral cord motor neurons, and others); PAG-3 is requiredto repress the touch neuron-specific genes mec-4 and mec-7 in BDUneurons, but since this repression does not occur in touch neurons(which also have PAG-3), PAG-3 may require another protein or proteinsfor repression (such as PRK-1 or PRK-2, the C. elegans orthologs ofhuman PIM-1); PAG-3 is also needed for normal neuroblast lineages in theventral nerve cord, and for normal locomotion; pag-3 mutants have areverse kinker uncoordinated phenotype, and occasional axonal guidanceerrors in the PLM and BDU neurons; PAG-3's similarity to GFI1 and GFIBfalls mainly within residues 159-261, but within these residues (whichoverlap PAG-3's five zinc-finger domains in residues 126-265) the aminoacid identity is 87%; pag-3 transcript quantities are doubled in pag-3mutants, suggesting that PAG-3 inhibits its own gene. | Paper_evidence | WBPaper00002355 | |||||
| WBPaper00002800 | |||||||||
| WBPaper00003922 | |||||||||
| WBPaper00005229 | |||||||||
| WBPaper00005359 | |||||||||
| WBPaper00028605 | |||||||||
| Person_evidence | WBPerson2238 | ||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 26 Oct 2006 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; and transcription corepressor binding activity. Involved in several processes, including negative regulation of secretion by cell; neuroblast fate specification; and regulation of locomotion. Located in nucleus. Expressed in several structures, including P1.aap; P11.aaap; P12.aaap; neurons; and retrovesicular ganglion. Used to study alcohol use disorder. Is an ortholog of human ZNF683 (zinc finger protein 683). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00041098 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 05 Jun 2019 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000696 | ||||||||
| Molecular_info | Corresponding_CDS | F45B8.4 | |||||||
| Corresponding_transcript | F45B8.4.1 | ||||||||
| Other_sequence (19) | |||||||||
| Associated_feature (12) | |||||||||
| Transcription_factor | WBTranscriptionFactor000513 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00027820 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00047348 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr521 | ||||||||
| Expr1872 | |||||||||
| Expr1018152 | |||||||||
| Expr1031844 | |||||||||
| Expr1151201 | |||||||||
| Expr1200026 | |||||||||
| Expr2014684 | |||||||||
| Expr2032917 | |||||||||
| Drives_construct | WBCnstr00012418 | ||||||||
| WBCnstr00035802 | |||||||||
| Construct_product | WBCnstr00012418 | ||||||||
| WBCnstr00020653 | |||||||||
| WBCnstr00021744 | |||||||||
| WBCnstr00035802 | |||||||||
| Antibody | WBAntibody00000504 | ||||||||
| Microarray_results | SMD_F45B8.4 | ||||||||
| 193449_at | |||||||||
| A_12_P116336 | |||||||||
| A_12_P147980 | |||||||||
| Aff_F45B8.4 | |||||||||
| GPL13394_WBGene00003909 | |||||||||
| GPL13914_F45B8.4 | |||||||||
| GPL14144_F45B8.4_133-192_0.883_16_C | |||||||||
| GPL14144_F45B8.4_541-600_0.906_10_A | |||||||||
| GPL14144_F45B8.4_641-700_0.927_4_B | |||||||||
| GPL19516_CGZ0012940 | |||||||||
| GPL19516_CGZ0021777 | |||||||||
| GPL21109_F45B8.4 | |||||||||
| GPL3518_CE24977 | |||||||||
| GPL8304_CE_WBGene00003909_A | |||||||||
| GPL8673_F45B8_4P00238 | |||||||||
| GPL8673_F45B8_4P00758 | |||||||||
| GPL8673_F45B8_4P00890 | |||||||||
| GPL9450_F45B8.4 | |||||||||
| cea2.c.45059 | |||||||||
| Expression_cluster (113) | |||||||||
| Interaction (51) | |||||||||
| WBProcess | WBbiopr:00000024 | ||||||||
| Map_info | Map | X | Position | 21.592 | Error | 0.004611 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F45B8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Y37H4 | |||||||||
| Mapping_data | 2_point | 7015 | |||||||
| Multi_point | 4508 | ||||||||
| 5033 | |||||||||
| Pos_neg_data (11) | |||||||||
| Reference (51) | |||||||||
| Method | Gene |
