WormBase Tree Display for Gene: WBGene00003893
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| WBGene00003893 | SMap | S_parent | Sequence | C44B12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ost-1 | |||||||
| Sequence_name | C44B12.2 | ||||||||
| Molecular_name | C44B12.2a | ||||||||
| C44B12.2a.1 | |||||||||
| CE08703 | |||||||||
| C44B12.2b | |||||||||
| CE48586 | |||||||||
| C44B12.2b.1 | |||||||||
| Other_name | SPARC/1 | ||||||||
| SPARC | Accession_evidence | EMBL | L21758 | ||||||
| CELE_C44B12.2 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | ost-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ost | ||||||||
| Allele (92) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes predicted protein with 38% identity to mammalian extracellular matrix protein SPARC/Osteonectin. ost-1:lacZ expressed in body wall muscle, vulval muscle. Transgene overexpression leads to deformity, variable locomotion defects. [Schwarzbauer and Spencer 1993] | ||||||||
| Strain | WBStrain00002655 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | ost-1 encodes the C. elegans ortholog of the conserved basement membrane glycoprotein component osteonectin/SPARC/BM-40; loss of ost-1 function via RNAi indicates that ost-1 activity is required for embryonic and larval development, as well as for normal gut development, body size, and fecundity; an OST-1::GFP reporter fusion protein localizes to the basement membranes along body wall and sex muscles, as well as around the pharynx and gonad, with particular concentration at the spermatheca and distal tip cells. | Paper_evidence | WBPaper00001812 | |||||
| WBPaper00002873 | |||||||||
| WBPaper00003285 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 29 Mar 2007 00:00:00 | ||||||||
| Automated_description | Enables calcium ion binding activity. Located in basement membrane and extracellular space. Expressed in body wall musculature; gonad; head; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); osteogenesis imperfecta type 17; and progressive osseous heteroplasia. Is an ortholog of human SPARC (secreted protein acidic and cysteine rich). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110338 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11219) | ||||
| DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11219) | ||||||
| DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11219) | ||||||
| DOID:2893 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11219) | ||||||
| DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11219) | ||||||
| DOID:2152 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11219) | ||||||
| DOID:0111535 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11219) | ||||||
| DOID:9538 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11219) | ||||||
| DOID:182 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11219) | ||||||
| Molecular_info | Corresponding_CDS | C44B12.2a | |||||||
| C44B12.2b | |||||||||
| Corresponding_transcript | C44B12.2a.1 | ||||||||
| C44B12.2b.1 | |||||||||
| Other_sequence (185) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00042417 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00001609 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027583 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00064054 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00001227 | ||||||||
| WBCnstr00001228 | |||||||||
| WBCnstr00002431 | |||||||||
| WBCnstr00004341 | |||||||||
| WBCnstr00012499 | |||||||||
| WBCnstr00012500 | |||||||||
| Construct_product | WBCnstr00012499 | ||||||||
| WBCnstr00012500 | |||||||||
| Antibody | WBAntibody00001818 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (234) | |||||||||
| Interaction (19) | |||||||||
| Map_info | Map | IV | Position | -22.0306 | Error | 0.044335 | |||
| Positive | Positive_clone | C44B12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| JS#L1 | |||||||||
| Mapping_data | Multi_point | 4561 | |||||||
| 4589 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (16) | |||||||||
| Remark | C44B12.7 appears to be a typo. this codes for reverse transcriptase. .2 codes for osteonectin. sdm 12/00 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
