WormBase Tree Display for Gene: WBGene00003890
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| WBGene00003890 | SMap | S_parent | Sequence | T20H4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | osm-10 | Person_evidence | WBPerson242 | |||||
| Sequence_name | T20H4.1 | ||||||||
| Molecular_name | T20H4.1a | ||||||||
| T20H4.1a.1 | |||||||||
| CE00750 | |||||||||
| T20H4.1b | |||||||||
| CE51605 | |||||||||
| T20H4.1b.1 | |||||||||
| Other_name | CELE_T20H4.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | osm-10 | ||||||||
| DB_info | Database | AceView | gene | 3I337 | |||||
| WormQTL | gene | WBGene00003890 | |||||||
| WormFlux | gene | WBGene00003890 | |||||||
| OMIM | disease | 256000 | |||||||
| gene | 602141 | ||||||||
| NDB | locus_tag | CELE_T20H4.1 | |||||||
| NCBI | gene | 191740 | |||||||
| RefSeq | protein | NM_001330924.2 | |||||||
| NM_066197.7 | |||||||||
| TrEMBL | UniProtAcc | A0A168H2S6 | |||||||
| Q22622 | |||||||||
| UniProt_GCRP | UniProtAcc | Q22622 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | osm | ||||||||
| Allele (30) | |||||||||
| Legacy_information | [C.elegansII] n1602 : specifically defective in osmotic avoidance; normal chemotaxis; normal garlic avoidance; normal nose touch response. NA1. Cloned: cosmid rescue [Bargmann et al. 1990; CX, KP] | ||||||||
| Strain | WBStrain00008277 | ||||||||
| WBStrain00008292 | |||||||||
| WBStrain00008293 | |||||||||
| WBStrain00008294 | |||||||||
| WBStrain00029473 | |||||||||
| WBStrain00027082 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (22) | |||||||||
| Structured_description | Concise_description | osm-10 encodes a novel protein conserved amongst several Caenorhabditis species; osm-10 activity is required for normal osmosensory signaling in the ASH sensory neuron; in regulating ASH-mediated osmosensation, osm-10 interacts genetically with eos-1 and eos-2; OSM-10 is expressed in the ASH, ASI, PHA, and PHB sensory neurons beginning just prior to hatching and continuing through larval and adult stages; OSM-10 localizes to cell bodies, sensory processes, and axons. | Paper_evidence | WBPaper00003408 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 25 Sep 2006 00:00:00 | ||||||||
| Automated_description | Enables osmosensor activity. Involved in osmosensory signaling pathway. Located in axon; cytoplasm; and neuronal cell body. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Disease_relevance | Mutations in the human NADH-Ubiquinone oxidoreductase Fe-S protein 8 (NDUFS8; orthologous to elegans T20H4.1), are associated with Leigh syndrome, which is an an early-onset progressive neurodegenerative disorder, characterized by progressive loss of mental and movement abilities (psychomotor regression) and typically results in death within a couple of years, usually due to respiratory failure. | Homo sapiens | Accession_evidence | OMIM | 256000 | |||
| 602141 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 15 Jun 2012 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T20H4.1a | |||||||
| T20H4.1b | |||||||||
| Corresponding_transcript | T20H4.1a.1 | ||||||||
| T20H4.1b.1 | |||||||||
| Associated_feature | WBsf645329 | ||||||||
| WBsf225227 | |||||||||
| WBsf225228 | |||||||||
| WBsf225229 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00035727 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00053670 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00018934 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005588 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065896 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram614 | ||||||||
| Expr515 | |||||||||
| Expr1266 | |||||||||
| Expr6725 | |||||||||
| Expr15400 | |||||||||
| Expr1022236 | |||||||||
| Expr1031833 | |||||||||
| Expr1157225 | |||||||||
| Expr2014639 | |||||||||
| Expr2032872 | |||||||||
| Drives_construct (17) | |||||||||
| Construct_product | WBCnstr00012411 | ||||||||
| WBCnstr00022367 | |||||||||
| WBCnstr00035810 | |||||||||
| Antibody | WBAntibody00000213 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (104) | |||||||||
| Interaction (14) | |||||||||
| Map_info | Map | III | Position | -0.764685 | Error | 0.000739 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | T20H4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 3719 | |||||||
| Multi_point | 1363 | ||||||||
| 4042 | |||||||||
| 4043 | |||||||||
| 4146 | |||||||||
| Pos_neg_data | 3720 | ||||||||
| 3721 | |||||||||
| Reference (39) | |||||||||
| Method | Gene |
