WormBase Tree Display for Gene: WBGene00003884
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| WBGene00003884 | SMap | S_parent | Sequence | M02B7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | osm-3 | Person_evidence | WBPerson242 | |||||
| Sequence_name | M02B7.3 | ||||||||
| Molecular_name (8) | |||||||||
| Other_name | caf-1 | ||||||||
| klp-2 | |||||||||
| CELE_M02B7.3 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | osm-3 | ||||||||
| DB_info | Database | AceView | gene | 4E562 | |||||
| WormQTL | gene | WBGene00003884 | |||||||
| WormFlux | gene | WBGene00003884 | |||||||
| NDB | locus_tag | CELE_M02B7.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003884|UniProtKB=P46873 | |||||||
| family | PTHR24115 | ||||||||
| NCBI | gene | 177141 | |||||||
| RefSeq | protein | NM_001380163.1 | |||||||
| NM_001380164.2 | |||||||||
| SwissProt | UniProtAcc | P46873 | |||||||
| TREEFAM | TREEFAM_ID | TF105223 | |||||||
| UniProt_GCRP | UniProtAcc | P46873 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | osm | ||||||||
| Reference_allele | WBVar00095126 | ||||||||
| Allele (75) | |||||||||
| Legacy_information | p802 : fails to avoid 4M fructose or 4M NaCl; non-chemotactic; defective dauer formation; normal thermotaxis; fails to take up FITC; eliminates distal segment of amphid channel cilia other ciliated neurons normal; octopamine-deficient. ES1 ME3. NA1. | ||||||||
| See also e1806, e1811, p802 | |||||||||
| hf3 : resistant to 30 mM caffeine; no gross phenotype. ES1. NA8. | |||||||||
| [Kari C] caf-1(hf3) is defective in dye (FITC or DiO) filling of amphid and phasmid neurons. | |||||||||
| [C.elegansII] p802 : fails to avoid 4M fructose or 4M NaCl; non-chemotactic; defective dauer formation; normal thermotaxis; fails to take up FITC; eliminates distal segment of amphid channel; cilia in other ciliated neurons normal; octopamine-deficient. ES1 ME3. OA>7: e1806, e1811, hf3 (pka caf-1, resistant to 30 mM caffeine, Dyf), etc. Cloned: encodes 672 aa kinesin-like protein, osm-3:lacZ expressed in all 26 sensory neurons with external openings. [Tabish et al. 1995; Starich et al. 1995] | |||||||||
| related to kinesin like protein by sequence similarity.[Siddiqui SS] | |||||||||
| Complementation_data | [Kari C] caf-1(hf3) fails to complement osm-3(p802) with respect to dye filling. caf-1(hf3) complements dyf-3(sa122). | ||||||||
| Strain | WBStrain00002574 | ||||||||
| WBStrain00027079 | |||||||||
| WBStrain00027089 | |||||||||
| WBStrain00030673 | |||||||||
| WBStrain00030794 | |||||||||
| WBStrain00034359 | |||||||||
| WBStrain00034363 | |||||||||
| WBStrain00040581 | |||||||||
| WBStrain00049023 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (52) | |||||||||
| Ortholog (30) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | osm-3 encodes a kinesin-2 family member that forms a homodimeric kinesin motor protein; OSM-3, in conjunction with the heterotrimeric kinesin-II composed of KLP-20, KLP-11, and KAP-1, is required for intraflagellar transport (IFT) along the middle segment of the cilia and on its own, is required for IFT along the distal segment; OSM-3 is thus also required for formation of the distal segment of amphid channel cilia, responses to osmotic stimuli, dauer formation, and sensitivity to caffeine; OSM-3 is intensely localized in the ciliated endings of amphid, inner labial, and phasmid chemosensory neurons and shows a punctate localization pattern in the corresponding cell bodies and dendrites. | Paper_evidence | WBPaper00001757 | |||||
| WBPaper00002154 | |||||||||
| WBPaper00003466 | |||||||||
| WBPaper00004178 | |||||||||
| WBPaper00028529 | |||||||||
| WBPaper00028530 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 13 Oct 2008 00:00:00 | ||||||||
| Automated_description | Enables plus-end-directed microtubule motor activity. Involved in several processes, including cilium organization; dauer entry; and regulation of non-motile cilium assembly. Located in neuronal cell body; perinuclear region of cytoplasm; and plasma membrane bounded cell projection. Part of kinesin complex. Expressed in ciliated neurons. Is an ortholog of human KIF17 (kinesin family member 17). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | M02B7.3a | |||||||
| M02B7.3b | |||||||||
| Corresponding_CDS_history | M02B7.3:wp82 | ||||||||
| Corresponding_transcript | M02B7.3a.1 | ||||||||
| M02B7.3a.2 | |||||||||
| M02B7.3a.3 | |||||||||
| M02B7.3b.1 | |||||||||
| Other_sequence | Dviv_isotig36133 | ||||||||
| Acan_isotig20221 | |||||||||
| Acan_isotig10473 | |||||||||
| Oden_isotig23182 | |||||||||
| JI173984.1 | |||||||||
| JI169383.1 | |||||||||
| JI173969.1 | |||||||||
| JO470440.1 | |||||||||
| JI168066.1 | |||||||||
| Oden_isotig23251 | |||||||||
| Associated_feature | WBsf996077 | ||||||||
| WBsf996078 | |||||||||
| WBsf996079 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00050810 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00063713 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017119 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (15) | |||||||||
| Drives_construct | WBCnstr00004404 | ||||||||
| WBCnstr00009059 | |||||||||
| WBCnstr00009060 | |||||||||
| WBCnstr00010345 | |||||||||
| WBCnstr00013043 | |||||||||
| WBCnstr00017227 | |||||||||
| WBCnstr00017229 | |||||||||
| WBCnstr00018169 | |||||||||
| WBCnstr00021214 | |||||||||
| WBCnstr00021218 | |||||||||
| Construct_product (13) | |||||||||
| Regulate_expr_cluster | WBPaper00061853:osm-3(dh441)_downregulated | ||||||||
| WBPaper00061853:osm-3(dh441)_downregulated_tunicamycin | |||||||||
| WBPaper00061853:osm-3(dh441)_upregulated | |||||||||
| WBPaper00061853:osm-3(dh441)_upregulated_tunicamycin | |||||||||
| Antibody | WBAntibody00000219 | ||||||||
| WBAntibody00001582 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (117) | |||||||||
| Interaction (65) | |||||||||
| Map_info | Map | IV | Position | -2.20722 | Error | 0.011645 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | K09B3 | |||||||
| M02B7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 364 | |||||||
| 365 | |||||||||
| 2593 | |||||||||
| 2594 | |||||||||
| 4522 | |||||||||
| 4523 | |||||||||
| Multi_point | 900 | ||||||||
| 903 | |||||||||
| 906 | |||||||||
| 962 | |||||||||
| 1569 | |||||||||
| Pos_neg_data | 1630 | ||||||||
| 1631 | |||||||||
| Reference (220) | |||||||||
| Method | Gene |
