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WormBase Tree Display for Gene: WBGene00003796

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Name Class

WBGene00003796SMapS_parentSequenceZK328
IdentityVersion1
NameCGC_namenpp-10Person_evidenceWBPerson1780
Sequence_nameZK328.5
Molecular_nameZK328.5a
ZK328.5a.1
CE44281
ZK328.5b
CE44292
ZK328.5c
CE44327
ZK328.5b.1
ZK328.5c.1
Other_nameNup96Paper_evidenceWBPaper00026834
Nup98Paper_evidenceWBPaper00026834
CELE_ZK328.5Accession_evidenceNDBBX284603
Public_namenpp-10
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnpp
Allele (84)
Possibly_affected_byWBVar02154080
StrainWBStrain00035673
WBStrain00022364
WBStrain00055401
WBStrain00054175
RNASeq_FPKM (74)
GO_annotation (51)
Ortholog (43)
Structured_descriptionConcise_descriptionnpp-10 is orthologous to the human gene NUCLEOPORIN, 98-KD (NUP98; OMIM:601021), which can promote leukemias (myelodysplastic syndromes, AML, or CML) when chromosomally rearranged.Curator_confirmedWBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables RNA binding activity. Involved in embryo development; organelle organization; and protein localization to organelle. Located in P granule; kinetochore; and nuclear envelope. Part of nuclear pore. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Is an ortholog of human NUP98 (nucleoporin 98 and 96 precursor).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:5603Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8068)
Molecular_infoCorresponding_CDSZK328.5a
ZK328.5b
ZK328.5c
Corresponding_CDS_historyZK328.5a:wp101
ZK328.5a:wp209
ZK328.5b:wp101
ZK328.5b:wp209
Corresponding_transcriptZK328.5a.1
ZK328.5b.1
ZK328.5c.1
Other_sequence (19)
Associated_featureWBsf655439
WBsf666428
WBsf666948
WBsf666949
WBsf226748
WBsf226749
WBsf226750
WBsf226751
Experimental_infoRNAi_result (21)
Expr_patternExpr9020
Expr9024
Expr1026045
Expr1031782
Expr1162768
Expr2014370
Expr2032611
Drives_constructWBCnstr00035863
WBCnstr00042404
Construct_productWBCnstr00006025
WBCnstr00013677
WBCnstr00035863
WBCnstr00042404
AntibodyWBAntibody00001025
WBAntibody00001887
WBAntibody00001888
WBAntibody00001893
WBAntibody00002138
WBAntibody00002139
Microarray_results (32)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00031132:LiCl_downregulated
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038289:oocyte_protein
WBPaper00040209:B.thuringiensis_upregulated_MY15
WBPaper00042477:prp-8(RNAi)_upregulated_RNAseq
WBPaper00044037:eat-2_downregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045571:germline-ablation_downregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048644:germline_enriched
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049217:TCER-1_downregulated
WBPaper00049498:npr-1(ur89)_regulated_6
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050015:ifg-1(RNAi)_upregulated
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050522:mafr-1(tm6082)_downregulated
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_nucleus_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051245:nucleus_specific
WBPaper00051245:pharyngeal-muscle_nucleus_expressed
WBPaper00051265:F1_morc-1(tm6048)_downregulated
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053615:SMO-1_target
WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00053814:25C_downregulated_OP50
WBPaper00053814:25C_downregulated_PY79
WBPaper00054913:AKIR-1_interacting_protein
WBPaper00055226:ADR-2_target_N2
WBPaper00055334:DLC-1_interacting
WBPaper00055648:germline_expressed
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056139:soil-microbiota_downregulated
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058598:sin-3(tm1276)_upregulated
WBPaper00058725:sftb-1(cer6)_upregulated
WBPaper00059027:neuron-synapses_enriched
WBPaper00059605:MUT-16_interacting
WBPaper00059664:srbc-48(ac23)_downregulated
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00060014:set-2(tm1630)_upregulated
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060871:M.humicola-infection_48h_regulated
WBPaper00061007:S.aquatilis_downregulated
WBPaper00061203:sin-3(tm1276)_downregulated
WBPaper00061203:spr-1(ok2144)_downregulated
WBPaper00061340:Excretory_cell_parent
WBPaper00061527:npp-6-mtr-4_21425
WBPaper00062123:GLH-1_interacting
WBPaper00062143:PQN-59_interacting
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062498:PPM-1.D_interacting
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
WBPaper00064071:NHR-49_interacting
WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
WBPaper00064716:paraquat_upregulated
WBPaper00064871:hypoxia_upregulated_F1
WBPaper00065096:25C_vs_20C_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_Ref
WBPaper00065945:epidermis-rpoa-2(-)_upregulated_transcript
WBPaper00065945:global-rpoa-2(-)_upregulated_transcript
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066110:tetraploid_vs_diploid_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4489_group_25
WBPaper00005124:progesterone_10-9M_regulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00030985:Erwinia_carotovora_downregulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031832:slr-2_regulated
WBPaper00032948:FedUp
WBPaper00036130:mir-243_down_regulated
WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
WBPaper00040821:Au-NP_regulated
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00045673:colistin_downregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00056330:mrps-5(RNAi)_downregulated
[cgc5767]:expression_class_E
[cgc5767]:expression_class_ET
[cgc5767]:expression_class_ET_max(66_min)
[cgc5767]:expression_class_E_pi(53_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc5767]:expression_class_MET
[cgc6390]:intrinsic
Interaction (183)
Map_infoMapIIIPosition-1.42704Error0.000206
PositivePositive_cloneZK328Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4248
4546
Pseudo_map_position
Reference (19)
RemarkSequence connection from [Askjaer P, Mattaj IW]. krb 13/11/01
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene