WormBase Tree Display for Gene: WBGene00003601
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| WBGene00003601 | Evidence | Paper_evidence | WBPaper00002779 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C32F10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | nhr-2 | Person_evidence | WBPerson600 | |||||
| Sequence_name | C32F10.6 | ||||||||
| Molecular_name | C32F10.6 | ||||||||
| C32F10.6.1 | |||||||||
| CE39002 | |||||||||
| Other_name | crf-2 | ||||||||
| CELE_C32F10.6 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | nhr-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nhr | ||||||||
| Allele (38) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes member of nuclear hormone receptor superfamily (pka crf-2). 50% identity to mouse thyroid hormone receptor in zinc finger region. NHR-2 present in embryonic nuclei at 2 cellstage, ubiquitous until gastrulation, later diminishes; transcript in maternal germline. Antisense expression leads to posterior necrosis in L4, adult. [Seydoux and Fire 1994; AE; GR] | ||||||||
| Strain | WBStrain00028896 | ||||||||
| WBStrain00030003 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Contained_in_operon | CEOP1897 | ||||||||
| Ortholog (41) | |||||||||
| Paralog (216) | |||||||||
| Structured_description | Concise_description | nhr-2 encodes a member of the nuclear hormone receptor family that is required for embryonic viability and morphogenesis; expressed during embryogenesis. | Paper_evidence | WBPaper00002044 | |||||
| WBPaper00003469 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation; hormone-mediated signaling pathway; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including Cpaaaa; Cpaaap; Cpaapa; Cpaapp; and germ line. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); congenital nongoitrous hypothyroidism 6; and cystic fibrosis. Is an ortholog of human PPARA (peroxisome proliferator activated receptor alpha) and THRA (thyroid hormone receptor alpha). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9232) | ||||
| DOID:1485 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9232) | ||||||
| DOID:9452 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9232) | ||||||
| DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9232) | ||||||
| DOID:0070128 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11796) | ||||||
| DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11796) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9232) | ||||||
| DOID:3146 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9232) | ||||||
| DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9232) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11796) | ||||||
| Molecular_info | Corresponding_CDS | C32F10.6 | |||||||
| Corresponding_CDS_history | C32F10.6:wp147 | ||||||||
| Corresponding_transcript | C32F10.6.1 | ||||||||
| Other_sequence | SR04400 | ||||||||
| JI166756.1 | |||||||||
| CR07066 | |||||||||
| SRC05723_1 | |||||||||
| Dviv_isotig29725 | |||||||||
| Hbac_isotig06552 | |||||||||
| CRC11806_1 | |||||||||
| Associated_feature | WBsf649193 | ||||||||
| WBsf664281 | |||||||||
| WBsf664282 | |||||||||
| WBsf664283 | |||||||||
| WBsf978463 | |||||||||
| WBsf983775 | |||||||||
| WBsf219488 | |||||||||
| WBsf219489 | |||||||||
| Gene_product_binds (291) | |||||||||
| Transcription_factor | WBTranscriptionFactor000729 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00076188 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00003066 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00086704 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003067 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041701 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007228 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027636 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00111897 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114322 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00064050 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00000073 | ||||||||
| WBCnstr00012498 | |||||||||
| WBCnstr00015288 | |||||||||
| WBCnstr00015391 | |||||||||
| WBCnstr00016505 | |||||||||
| WBCnstr00017939 | |||||||||
| WBCnstr00020357 | |||||||||
| WBCnstr00036011 | |||||||||
| Construct_product | WBCnstr00012498 | ||||||||
| WBCnstr00015391 | |||||||||
| WBCnstr00016594 | |||||||||
| WBCnstr00036011 | |||||||||
| Antibody | WBAntibody00000144 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (226) | |||||||||
| Interaction (200) | |||||||||
| Product_binds_matrix | WBPmat00005560 | ||||||||
| WBPmat00005561 | |||||||||
| Map_info | Map | I | Position | 0.464502 | Error | 0.000795 | |||
| Positive | Positive_clone | AD7 | Person_evidence | WBPerson600 | |||||
| C32F10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 4517 | |||||||
| 4926 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (27) | |||||||||
| Remark | Sluder et al., 1997 [021217 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
