WormBase Tree Display for Gene: WBGene00003563

WBGene00003563 SMap: S_parent: Sequence: C44C1
  Identity: Version: 1
    Name: CGC_name: ncs-1
      Sequence_name: C44C1.3
      Molecular_name: C44C1.3
        C44C1.3.1
        CE24845
      Other_name: CELE_C44C1.3 Accession_evidence: NDB BX284606
      Public_name: ncs-1
    DB_info: Database: AceView gene XB580
        WormQTL gene WBGene00003563
        WormFlux gene WBGene00003563
        NDB locus_tag CELE_C44C1.3
        Panther gene CAEEL|WormBase=WBGene00003563|UniProtKB=P36608
          family PTHR23055
        NCBI gene 180448
        RefSeq protein NM_075785.4
        SwissProt UniProtAcc P36608
        UniProt_GCRP UniProtAcc P36608
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ncs
    Allele (41)
    Legacy_information: Calcium and NCS-1 are essential for isothermal track behavior (conditioning behavior with food and temperature).A functional NCS-1 is necessary in the AIY interneuron (not in AFD).The amount of NCS-1 regulates this associative learning and memory behaviour (more NCS-1 means faster learning and longer memory,no NCS-1 means absence of associative learning). [email from Patrick Nef 0106]
    Strain: WBStrain00040596
    RNASeq_FPKM (74)
    GO_annotation: 00044962
      00044963
      00044964
      00044965
      00044966
      00044967
      00044968
      00044969
      00044970
      00111140
    Ortholog (34)
    Paralog: WBGene00003565 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00008998 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021116 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008307 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00015867 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003564 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007710 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: The ncs-1 gene encodes a neuronal calcium sensor protein that, along with calcium, is essential for thermotaxis along isothermal paths in thermal gradients. Paper_evidence: WBPaper00004666
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Involved in chemosensory behavior; chemotaxis; and response to alkaline pH. Located in neuronal cell body. Expressed in head neurons; pm1; and tail neurons. Is an ortholog of human NCS1 (neuronal calcium sensor 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C44C1.3
    Corresponding_transcript: C44C1.3.1
    Other_sequence (31)
    Associated_feature: WBsf1003905
      WBsf236982
  Experimental_info: RNAi_result: WBRNAi00042442 Inferred_automatically: RNAi_primary
      WBRNAi00090678 Inferred_automatically: RNAi_primary
      WBRNAi00011923 Inferred_automatically: RNAi_primary
      WBRNAi00011924 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr892
      Expr893
      Expr13260
      Expr1020033
      Expr1146432
      Expr2013910
      Expr2032150
    Drives_construct: WBCnstr00008347
      WBCnstr00013614
      WBCnstr00018283
      WBCnstr00036041
    Construct_product: WBCnstr00036041
    Antibody: WBAntibody00000364
    Microarray_results (19)
    Expression_cluster (105)
    Interaction (30)
  Map_info: Map: X Position: -18.8811 Error: 0.001861
    Positive: Positive_clone: C44C1 Person_evidence: WBPerson1321
          Author_evidence: de Castro E
          Inferred_automatically: From sequence, transcript, pseudogene data
        F53H8 Person_evidence: WBPerson1321
          Author_evidence: de Castro E
    Mapping_data: Multi_point: 4512
    Pseudo_map_position
  Reference (29)
  Remark: [de Castro E, Nef P] Tc1 insertion obtained (pk242), also excision derivative. ncs for Neuronal Calcium Sensor. Region already sequenced, but in ACEDB ncs-1 gene (C44C1.3) is just named "similar to frequenin and other EF Hand calcium binding proteins" and there are errors in the intron/exon boundaries ("compared" to our cDNA), 3 parts of the 2nd intron are considered as exons ([viknfesrskiiilqllffky,ielyiptvkcfvpeksdise,pvkcmdpffdvlvlfsietshn] a.a. are in excess!) (we do not observe alt. splicing) Ce-NCS-1: cDNA: genbank name CELNCS1, accession L33680; Protein: Swiss Prot name NCS1_CAEEL, accession p36608
    X -18.85
    [P Nef] Gomez M, De Castro E, Guarin E, Sasakura H, Kuhara A, Mori I, Bartfai T, Bargmann CI, Nef P. Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans. Neuron. 2001 Apr;30(1):241-8.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene