WormBase Tree Display for Gene: WBGene00003553
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| WBGene00003553 | Evidence | Author_evidence | Moehrlen F | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C17G1 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | nas-37 | Person_evidence | WBPerson1103 | |||||
| Sequence_name | C17G1.6 | ||||||||
| Molecular_name | C17G1.6a | ||||||||
| C17G1.6a.1 | |||||||||
| CE31417 | |||||||||
| C17G1.6b | |||||||||
| CE38034 | |||||||||
| C17G1.6b.1 | |||||||||
| Other_name | CELE_C17G1.6 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | nas-37 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nas | ||||||||
| Allele (69) | |||||||||
| Strain | WBStrain00002602 | ||||||||
| WBStrain00037444 | |||||||||
| WBStrain00006660 | |||||||||
| WBStrain00006680 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (31) | |||||||||
| Paralog (48) | |||||||||
| Structured_description | Concise_description | nas-37 encodes a Astacin-class metalloprotease required for full ecdysisthat is expressed in hypodermal cells 4 hours before each ecdysis; NAS-37protein has an N-terminal signal sequence followed by an Astacin proteasedomain and three protein-binding domains (EGF-like, CUB, andthrombospondin); NAS-37 accumulates in anterior cuticle, being shed withit after ecdysis; nas-37 mutants fail to complete anterior ecdysis at eachmolt; nas-37(ox196) mutations alter an evolutionarily invariant histidineresidue yet are phenotypically indistinguishable from null mutations,consistent with the hypothesis that NAS-37 encodes a functional protease;NAS-37 orthologs are found in other nematodes such as Brugia malayi. | Paper_evidence | WBPaper00024579 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 16 Dec 2010 00:00:00 | ||||||||
| Automated_description | Enables metalloendopeptidase activity. Involved in collagen and cuticulin-based cuticle development and ecdysis, collagen and cuticulin-based cuticle. Located in extracellular region. Expressed in cuticle; epithelial cell; intestine; and rectal gland cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C17G1.6a | |||||||
| C17G1.6b | |||||||||
| Corresponding_CDS_history | C17G1.6:wp83 | ||||||||
| Corresponding_transcript | C17G1.6a.1 | ||||||||
| C17G1.6b.1 | |||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf1006575 | ||||||||
| WBsf1006576 | |||||||||
| WBsf1006577 | |||||||||
| WBsf1023644 | |||||||||
| WBsf237814 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product | WBCnstr00006847 | ||||||||
| WBCnstr00011093 | |||||||||
| WBCnstr00011155 | |||||||||
| WBCnstr00013626 | |||||||||
| WBCnstr00036048 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (174) | |||||||||
| Interaction (15) | |||||||||
| Map_info | Map | X | Position | 1.73123 | Error | 0.000121 | |||
| Positive | Positive_clone | C17G1 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5083 | |||||||
| Pseudo_map_position | |||||||||
| Reference (18) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
