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WormBase Tree Display for Gene: WBGene00003474

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Name Class

WBGene00003474SMapS_parentSequenceT08G5
IdentityVersion1
NameCGC_namemtl-2Person_evidenceWBPerson1414
Sequence_nameT08G5.10
Molecular_nameT08G5.10
T08G5.10.1
CE25109
Other_namemet-IIAccession_evidenceEMBLX53245
D17365
CELE_T08G5.10Accession_evidenceNDBBX284605
Public_namemtl-2
DB_infoDatabaseAceViewgene5O498
WormQTLgeneWBGene00003474
WormFluxgeneWBGene00003474
NDBlocus_tagCELE_T08G5.10
NCBIgene179899
RefSeqproteinNM_074081.9
SwissProtUniProtAccP17512
UniProt_GCRPUniProtAccP17512
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmtl
Allele (15)
Legacy_information[C.elegansII] NMK. Encodes 63 aa metallothionein; accumulates after exposure to CdCl2. mtl-1:lacZ expressed in intestine after cadmium treatment or heat shock. [Freedman et al. 1993]
StrainWBStrain00005079
WBStrain00005080
WBStrain00005081
WBStrain00005101
WBStrain00040877
WBStrain00035525
RNASeq_FPKM (74)
GO_annotation00039557
00039558
00106045
00106046
00106267
00106268
OrthologWBGene00027389Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
WBGene00027390Caenorhabditis briggsaeFrom_analysisOrthoMCL
Inparanoid_8
WormBase-Compara
WBGene00151369Caenorhabditis brenneriFrom_analysisOMA
Inparanoid_8
WormBase-Compara
WBGene00271681Caenorhabditis briggsaeFrom_analysisWormBase-Compara
FL83_06429Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_020394Caenorhabditis remaneiFrom_analysisWormBase-Compara
chrV_pilon.g16404Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00057046Caenorhabditis remaneiFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionmtl-2 encodes one of two C. elegans metallothioneins, small, cysteine-rich, metal-binding proteins; MTL-2 functions in metal detoxification and homeostasis and stress adaptation; in addition, mtl-2 plays a role in regulating growth and fertility; mtl-2 expression is induced in larval and adult intestinal cells following exposure to cadmium or heat shock; MTL-2 intestinal expression is dependent upon ELT-2, an intestine-specific GATA-type transcription factor; mtl-2 is downregulated by DAF-16 in daf-2 mutants.Paper_evidenceWBPaper00001688
WBPaper00003700
WBPaper00004299
WBPaper00004381
WBPaper00005295
WBPaper00005976
WBPaper00028866
Curator_confirmedWBPerson1843
Date_last_updated07 May 2007 00:00:00
Automated_descriptionEnables cadmium ion binding activity and zinc ion binding activity. Involved in response to cadmium ion and response to heat. Expressed in intestinal cell and intestine.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDST08G5.10
Corresponding_transcriptT08G5.10.1
Other_sequenceCBC00932_1
CBC01514_2
FD517649.1
CBC01514_1
CJC01860_1
CSC00487_1
FD517704.1
Associated_featureWBsf653359
WBsf919637
WBsf919638
WBsf982357
WBsf982358
WBsf234895
Experimental_infoRNAi_result (11)
Expr_patternExpr1380
Expr1509
Expr3079
Expr1020789
Expr1156496
Expr2013808
Expr2032048
Drives_construct (15)
Construct_productWBCnstr00007972
WBCnstr00007973
WBCnstr00011119
WBCnstr00036093
Microarray_results (19)
Expression_cluster (257)
Interaction (39)
WBProcessWBbiopr:00000039
WBbiopr:00000050
WBbiopr:00000053
WBbiopr:00000096
Map_infoMapVPosition6.07164Error0.009738
PositivePositive_cloneCR#MT2
T08G5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4288
4500
Pseudo_map_position
ReferenceWBPaper00001688
WBPaper00002326
WBPaper00002660
WBPaper00003210
WBPaper00003700
WBPaper00004255
WBPaper00005295
WBPaper00005312
WBPaper00005976
WBPaper00006437
WBPaper00011056
WBPaper00020783
WBPaper00022556
WBPaper00023053
WBPaper00023447
WBPaper00024190
WBPaper00024351
WBPaper00025370
WBPaper00025433
WBPaper00026592
WBPaper00027264
WBPaper00027309
WBPaper00027584
WBPaper00027642
WBPaper00028564
WBPaper00028782
WBPaper00028866
WBPaper00030811
WBPaper00032518
WBPaper00033210
WBPaper00033444
WBPaper00034499
WBPaper00034661
WBPaper00036001
WBPaper00036389
WBPaper00036743
WBPaper00037044
WBPaper00037835
WBPaper00038506
WBPaper00038729
WBPaper00038942
WBPaper00038996
WBPaper00039992
WBPaper00040044
WBPaper00040519
WBPaper00041036
WBPaper00042179
WBPaper00042606
WBPaper00042865
WBPaper00042867
WBPaper00044127
WBPaper00044243
WBPaper00044641
WBPaper00045040
WBPaper00046211
WBPaper00048380
WBPaper00048459
WBPaper00049204
WBPaper00050950
WBPaper00051639
WBPaper00051907
WBPaper00052350
WBPaper00053286
WBPaper00053737
WBPaper00056297
WBPaper00058783
WBPaper00059429
WBPaper00059551
WBPaper00063411
WBPaper00064255
WBPaper00065088
WBPaper00065134
WBPaper00066294
WBPaper00066337
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene