WormBase Tree Display for Gene: WBGene00003387
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| WBGene00003387 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y54E10BR | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mod-5 | Person_evidence | WBPerson268 | |||||
| Sequence_name | Y54E10BR.7 | ||||||||
| Molecular_name | Y54E10BR.7 | ||||||||
| Y54E10BR.7.1 | |||||||||
| CE28995 | |||||||||
| Other_name | Y54E10BR.b | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y54E10BR.7 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | mod-5 | ||||||||
| DB_info | Database | AceView | gene | 1D604 | |||||
| WormQTL | gene | WBGene00003387 | |||||||
| WormFlux | gene | WBGene00003387 | |||||||
| NDB | locus_tag | CELE_Y54E10BR.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003387|UniProtKB=Q9N3C7 | |||||||
| family | PTHR11616 | ||||||||
| NCBI | gene | 171879 | |||||||
| RefSeq | protein | NM_058694.4 | |||||||
| TrEMBL | UniProtAcc | Q9N3C7 | |||||||
| UniProt_GCRP | UniProtAcc | Q9N3C7 | |||||||
| OMIM | gene | 182138 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mod | ||||||||
| Allele (285) | |||||||||
| Legacy_information | [Ranganathan R] Modulation of locomotion defective. Hypersensitive to serotonin in assays of locomotion. | ||||||||
| Strain | WBStrain00027352 | ||||||||
| WBStrain00027366 | |||||||||
| WBStrain00027389 | |||||||||
| WBStrain00006656 | |||||||||
| WBStrain00051808 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (39) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | mod-5 encodes a Na[+],Cl[-]-dependent serotonin transporter that is required for serotonin uptake by neurosecretory motor neurons and for the experience-dependent enhanced slowing response to food; MOD-5 has serotonin transport activity in cell culture, and is a target of the serotonin uptake inhibitor fluoxetine (Prozac) in vivo; MOD-5 is orthologous to the human serotonin transporter (SLC6A4, OMIM:182138, associated with varying levels of neuroticism, introversion, and anxiety). | Paper_evidence | WBPaper00004809 | |||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables serotonin:sodium:chloride symporter activity. Involved in serotonin uptake. Predicted to be located in neuron projection. Expressed in several structures, including nerve ring. Used to study cocaine abuse. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; alexithymia; and attention deficit hyperactivity disorder. Is an ortholog of human SLC6A4 (solute carrier family 6 member 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:809 | Homo sapiens | Paper_evidence | WBPaper00034643 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 28 May 2019 00:00:00 | ||||||||
| Potential_model (23) | |||||||||
| Models_disease_asserted | WBDOannot00000682 | ||||||||
| Molecular_info | Corresponding_CDS | Y54E10BR.7 | |||||||
| Corresponding_transcript | Y54E10BR.7.1 | ||||||||
| Other_sequence | JI182100.1 | ||||||||
| ACC22817_1 | |||||||||
| ES672715.1 | |||||||||
| CRC04707_1 | |||||||||
| Dviv_isotig27782 | |||||||||
| SS01616 | |||||||||
| CR06131 | |||||||||
| Associated_feature | WBsf664007 | ||||||||
| WBsf717471 | |||||||||
| WBsf983050 | |||||||||
| WBsf983051 | |||||||||
| WBsf983052 | |||||||||
| WBsf1009445 | |||||||||
| WBsf1009446 | |||||||||
| WBsf219092 | |||||||||
| WBsf219093 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00057365 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00113742 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00113746 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00004736 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr9349 | ||||||||
| Expr9350 | |||||||||
| Expr9351 | |||||||||
| Expr1029124 | |||||||||
| Expr1160802 | |||||||||
| Expr2013646 | |||||||||
| Expr2031880 | |||||||||
| Drives_construct | WBCnstr00013917 | ||||||||
| WBCnstr00013918 | |||||||||
| Antibody | WBAntibody00002265 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (95) | |||||||||
| Interaction | WBInteraction000001398 | ||||||||
| WBInteraction000001399 | |||||||||
| WBInteraction000029562 | |||||||||
| WBInteraction000031265 | |||||||||
| WBInteraction000162267 | |||||||||
| WBInteraction000162559 | |||||||||
| WBInteraction000165837 | |||||||||
| WBInteraction000166111 | |||||||||
| WBInteraction000426665 | |||||||||
| WBInteraction000471671 | |||||||||
| Map_info | Map | I | Position | -4.51354 | Error | 0.034726 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | Y54E10A_154 | |||||||
| Y54E10BR | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 3833 | |||||||
| 3831 | |||||||||
| 3834 | |||||||||
| 3835 | |||||||||
| 3873 | |||||||||
| 3832 | |||||||||
| Reference (79) | |||||||||
| Remark | mod-5 was once called dmo-5. Y54E10BR.7 is the real CGC-approved mod-5, and all the Ranganathan genetic mapping data belong to it, as mod-5, reference allele n822. The gene dmo-5 (reference allele t1502, cgc3363) is something different, but was originally incorrectly published. The allele t1502 is therefore, deleted from mod-5 | CGC_data_submission | |||||||
| Method | Gene |
