WormBase Tree Display for Gene: WBGene00003335
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| WBGene00003335 | Evidence | Paper_evidence | WBPaper00005825 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F56A12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mir-241 | Person_evidence | WBPerson18 | |||||
| Sequence_name | F56A12.4 | ||||||||
| Molecular_name | F56A12.4 | ||||||||
| F56A12.4a | |||||||||
| F56A12.4b | |||||||||
| Other_name | cel-mir-241 | Remark | miRBase V21 import | ||||||
| Cel-Let-7-P8 | Remark | MirGeneDB 2.1 import | |||||||
| CELE_F56A12.4 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | mir-241 | ||||||||
| DB_info | Database | miRBase | acc | MI0000317 | |||||
| SignaLink | mirna | cel-mir-241 | |||||||
| MirGeneDB | cel | Cel-Let-7-P8 | |||||||
| NDB | locus_tag | CELE_F56A12.4 | |||||||
| NCBI | gene | 3565950 | |||||||
| RefSeq | protein | NR_002403.2 | |||||||
| RNAcentral | URSid | URS00002BFC83 | |||||||
| URS000040AE62 | |||||||||
| URS000040F239 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001265 | |||||||
| Gene_class | mir | ||||||||
| Allele (11) | |||||||||
| Strain | WBStrain00027442 | ||||||||
| WBStrain00027449 | |||||||||
| WBStrain00027441 | |||||||||
| WBStrain00040223 | |||||||||
| WBStrain00040225 | |||||||||
| WBStrain00040228 | |||||||||
| WBStrain00051617 | |||||||||
| In_cluster | LET-7 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00106260 | ||||||||
| 00106261 | |||||||||
| Structured_description | Concise_description | mir-241 encodes a microRNA, a small non-protein coding RNA and appears to have a potential ortholog in C. briggsae; based on RNA sequence identity, miR-241 belongs to the let-7 family of microRNAs along with C. elegans miR-48 and miR-84 and human let-7, miR-196-1 and miR-196-2; mir-241 acts redundantly with miR-48 and mir-84 to control L2 to L3 larval and larval to adult stage transitions; miR-241 is strongly expressed from the L3 larval stage into the adult stage in normal worms and in glp-4(bn2) mutant worms. | Paper_evidence | WBPaper00005825 | |||||
| WBPaper00010853 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 08 Feb 2005 00:00:00 | ||||||||
| Automated_description | Involved in miRNA-mediated gene silencing by inhibition of translation and positive regulation of development, heterochronic. Expressed in body wall musculature; excretory canal; hermaphrodite distal tip cell; and touch receptor neurons. Used to study Parkinson's disease. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00035654 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jan 2014 00:00:00 | ||||||||
| Disease_relevance | mir-241 is a small non-protein coding RNA that belongs to the let-7 family; microRNA expression profiling studies indicate that mir-241 is overexpressed in an elegans Parkinson''s disease model, the pdr-1 mutant (pdr-1 is orthologous to human PARKIN). | Homo sapiens | Paper_evidence | WBPaper00035654 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jan 2014 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000268 | ||||||||
| Molecular_info | Corresponding_transcript | F56A12.4 | |||||||
| F56A12.4a | |||||||||
| F56A12.4b | |||||||||
| Associated_feature | WBsf034325 | ||||||||
| WBsf979128 | |||||||||
| WBsf1001991 | |||||||||
| WBsf1001992 | |||||||||
| WBsf1001993 | |||||||||
| WBsf1001994 | |||||||||
| WBsf1020828 | |||||||||
| WBsf1020829 | |||||||||
| WBsf1020830 | |||||||||
| WBsf1020831 | |||||||||
| Experimental_info | Expr_pattern (11) | ||||||||
| Drives_construct | WBCnstr00005522 | ||||||||
| WBCnstr00011651 | |||||||||
| WBCnstr00015774 | |||||||||
| WBCnstr00015775 | |||||||||
| WBCnstr00017833 | |||||||||
| Construct_product | WBCnstr00015775 | ||||||||
| Expression_cluster (38) | |||||||||
| Interaction (17) | |||||||||
| WBProcess | WBbiopr:00000083 | ||||||||
| Map_info | Map | V | Position | 6.27847 | Error | 0.001234 | |||
| Positive | Inside_rearr | nDf51 | |||||||
| Positive_clone | F56A12 | Inferred_automatically | From CDS info | ||||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5653 | |||||||
| Pos_neg_data | 10750 | ||||||||
| Pseudo_map_position | |||||||||
| Reference (52) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
