mir-34 encodes a microRNA, a small non-protein coding RNA; miR-34 expression increases during adulthood, and loss of mir-34 activity results in increased adult lifespan along with increased resistance to heat and oxidative stress; in regulating adult lifespan, mir-34 functions via negative regulation of autophagy; mir-34 is conserved in C. briggsae as well as in Drosophila and humans.
Involved in several processes, including determination of adult lifespan; negative regulation of autophagy; and response to heat. Expressed in excretory canal; hypodermis; neurons; somatic nervous system; and vulval precursor cell.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.