WormBase Tree Display for Gene: WBGene00003260
expand all nodes | collapse all nodes | view schema
| WBGene00003260 | Evidence | Paper_evidence | WBPaper00004928 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WBPaper00005879 | |||||||||
| SMap | S_parent | Sequence | T09B4 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mir-1 | Person_evidence | WBPerson18 | |||||
| Sequence_name | T09B4.11 | ||||||||
| Molecular_name | T09B4.11 | ||||||||
| T09B4.11a | |||||||||
| T09B4.11b | |||||||||
| Other_name | cel-mir-1 | Remark | miRBase V21 import | ||||||
| MirGeneDB 2.1 import | |||||||||
| CELE_T09B4.11 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | mir-1 | ||||||||
| DB_info | Database | miRBase | acc | MI0000003 | |||||
| SignaLink | mirna | cel-mir-1 | |||||||
| MirGeneDB | cel | Cel-Mir-1 | |||||||
| NDB | locus_tag | CELE_T09B4.11 | |||||||
| NCBI | gene | 260145 | |||||||
| RefSeq | protein | NR_000172.2 | |||||||
| RNAcentral | URSid | URS0000348947 | |||||||
| URS000040D2F8 | |||||||||
| URS00004AFA66 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001265 | |||||||
| Gene_class | mir | ||||||||
| Allele (11) | |||||||||
| Strain | WBStrain00027408 | ||||||||
| WBStrain00027409 | |||||||||
| WBStrain00027582 | |||||||||
| WBStrain00035886 | |||||||||
| WBStrain00026615 | |||||||||
| In_cluster | MIR-1 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| Structured_description | Concise_description | mir-1 encodes a muscle-specific microRNA (miRNA) conserved in Caenorhabditis briggsae, Drosophila, mice, and humans; miR-1 activity is required for proper pre- and postsynaptic functions at neuromuscular junctions; postsynaptic targets of miR-1 include the UNC-29 and UNC-63 nicotinic acetylcholine receptors and the MEF-2 muscle transcription factor; miR-1 regulation of presynaptic function is mediated by a MEF-2-dependent retrograde signal that requires the RAB-3 synaptic vesicle GTPase; miR-1 is expressed at uniform levels throughout C. elegans development and is also detected in him-8 mutant animals as well as dauer and starved L1 larvae; a mir-1::gfp transcriptional fusion is expressed in pharyngeal and body wall muscle. | Paper_evidence | WBPaper00004928 | |||||
| WBPaper00031913 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 Jun 2008 00:00:00 | ||||||||
| Automated_description | Expressed in body wall musculature; muscle cell; and pharyngeal muscle cell. Used to study Parkinson's disease. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00035654 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jan 2014 00:00:00 | ||||||||
| Disease_relevance | mir-1 is a small muscle-specific non-protein coding RNA; microRNA expression profiling studies in an elegans transgenic model of Parkinson''s disease, where A53T alpha-synuclein is overexpressed, indicate that elegans mir-1 is differentially expressed; separate studies in elegans show that a retrograde signal from muscle to motor neurons that inhibits acetylcholine release at neuromuscular junctions, is induced by inactivation of mir-1 and abolished by inactivating the transcription factor, mef-2, a mir-1 target; mef-2 along with the elegans synaptic adhesion molecules, Neurexin (nrx-1) and Neuroligin (nlg-1), mediates the retrograde synaptic signal, mutations in all three human genes are associated with autism spectrum disorder and alter cognition based on their perturbation of synapse development and function; mutations inactivating nlg-1, nrx-1 and mef-2 in C. elegans, are all associated with prolonged ACh release; such studies support additional mechanisms by which synapse function can be perturbed, leading to cognitive disorders. | Homo sapiens | Paper_evidence | WBPaper00035654 | |||||
| WBPaper00041363 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jan 2014 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000262 | ||||||||
| Molecular_info | Corresponding_transcript | T09B4.11 | |||||||
| T09B4.11a | |||||||||
| T09B4.11b | |||||||||
| Associated_feature | WBsf983854 | ||||||||
| WBsf983855 | |||||||||
| WBsf1009912 | |||||||||
| Experimental_info | Expr_pattern | Expr1664 | |||||||
| Expr2467 | |||||||||
| Expr8106 | |||||||||
| Expr8411 | |||||||||
| Expr12251 | |||||||||
| Expr13549 | |||||||||
| Drives_construct | WBCnstr00000979 | ||||||||
| WBCnstr00005544 | |||||||||
| WBCnstr00013114 | |||||||||
| WBCnstr00019508 | |||||||||
| Regulate_expr_cluster | WBPaper00058945:mir-1(gk276)_downregulated | ||||||||
| WBPaper00058945:mir-1(gk276)_upregulated | |||||||||
| WBPaper00061740:mir-1(gk276)_downregulated_protein | |||||||||
| WBPaper00061740:mir-1(gk276)_upregulated_protein | |||||||||
| Expression_cluster (18) | |||||||||
| Interaction | WBInteraction000503662 | ||||||||
| WBInteraction000503663 | |||||||||
| WBInteraction000503664 | |||||||||
| WBInteraction000542242 | |||||||||
| Map_info | Map | I | Position | 0.867368 | Error | 0.006934 | |||
| Positive | Positive_clone | T09B4 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4217 | |||||||
| 5447 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
