WormBase Tree Display for Gene: WBGene00003230
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WBGene00003230 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | W02A2 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | mex | ||||||
Allele (51) | |||||||
Legacy_information | [Priess, J.] zu199: maternal-effect lethal mutation. Embryos produce excess intestine and pharyngeal muscle from the AB blastomere, while germ cells appear normal in most embryos by morphological criteria. | ||||||
Strain (15) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (21) | |||||||
Ortholog (30) | |||||||
Paralog (20) | |||||||
Structured_description | Concise_description | mex-5 encodes a novel protein that contains two CCCH zinc finger motifs; maternally provided MEX-5, which functions partly redundantly with the highly similar CCCH finger protein MEX-6, is essential for transducing polarity cues and establishing soma/germline asymmetry in the early embryo; in regulating soma/germline asymmetry, MEX-5 interacts with, and activates, the SOCS-box protein ZIF-1, which functions as part of an E3 ubiquitin ligase complex that degrades germ plasm proteins in somatic blastomeres; accordingly, ectopic expression of MEX-5 throughout the early embryo results in reduced expression of germline proteins in germline blastomeres; MEX-5 activity is regulated in vivo by PLK-1 and PLK-2, which presumably bind and phosphorylate MBK-2-primed MEX-5; MEX-5 is a cytoplasmic protein expressed at uniform levels in oocytes and newly fertilized eggs; from the 1-cell to 4-cell stages of embryogenesis, MEX-5 expression is dynamic, with highest levels seen in the anterior AB blastomere and, for a time, its daughters, the anterior portion of the P1 blastomere, P1 centrosomes (both, then posterior only), and the EMS and C blastomeres; the asymmetric distribution of MEX-5 in early embryos depends upon a phosphorylation/dephosphorylation cycle by the PAR-1 kinase and PP2A phosphatases including LET-92, that regulate MEX-5's association with slow- or fast-diffusing RNA-containing complexes. | Paper_evidence | WBPaper00004112 | |||
WBPaper00005160 | |||||||
WBPaper00005735 | |||||||
WBPaper00005930 | |||||||
WBPaper00006004 | |||||||
WBPaper00031434 | |||||||
WBPaper00040201 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 03 Oct 2011 00:00:00 | ||||||
Automated_description | Enables RNA binding activity; protein domain specific binding activity; and protein kinase binding activity. Involved in regulation of protein localization. Located in P granule and centrosome. Expressed in germ line; head muscle; head neurons; intestine; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | W02A2.7 | |||||
Corresponding_transcript | W02A2.7.1 | ||||||
Other_sequence (40) | |||||||
Associated_feature | WBsf977016 | ||||||
WBsf977017 | |||||||
WBsf977018 | |||||||
WBsf977019 | |||||||
WBsf977020 | |||||||
WBsf977021 | |||||||
WBsf977022 | |||||||
WBsf978625 | |||||||
WBsf229424 | |||||||
WBsf229425 | |||||||
Gene_product_binds | WBsf034344 | ||||||
WBsf034345 | |||||||
WBsf034346 | |||||||
WBsf034347 | |||||||
WBsf034348 | |||||||
WBsf034349 | |||||||
WBsf034350 | |||||||
WBsf034351 | |||||||
WBsf034352 | |||||||
Transcription_factor | WBTranscriptionFactor000124 | ||||||
Experimental_info | RNAi_result (42) | ||||||
Expr_pattern | Expr2463 | ||||||
Expr4082 | |||||||
Expr7693 | |||||||
Expr1027384 | |||||||
Expr1031527 | |||||||
Expr1158094 | |||||||
Expr2013543 | |||||||
Expr2031777 | |||||||
Drives_construct (165) | |||||||
Construct_product (27) | |||||||
Antibody | WBAntibody00000279 | ||||||
WBAntibody00000903 | |||||||
WBAntibody00001692 | |||||||
WBAntibody00002283 | |||||||
WBAntibody00002284 | |||||||
WBAntibody00002285 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (219) | |||||||
Interaction (311) | |||||||
WBProcess | WBbiopr:00000017 | ||||||
Map_info | Map | IV | Position | 8.5394 | Error | 0.011779 | |
Well_ordered | |||||||
Positive | Positive_clone | W02A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 3912 | |||||
3913 | |||||||
4914 | |||||||
Reference (109) | |||||||
Method | Gene |