WormBase Tree Display for Gene: WBGene00003221
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| WBGene00003221 | SMap | S_parent | Sequence | F54C1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mes-3 | Person_evidence | WBPerson632 | |||||
| Sequence_name | F54C1.3 | ||||||||
| Molecular_name | F54C1.3a | ||||||||
| F54C1.3a.1 | |||||||||
| CE11046 | |||||||||
| F54C1.3b | |||||||||
| CE53747 | |||||||||
| F54C1.3a.2 | |||||||||
| F54C1.3b.1 | |||||||||
| Other_name | CELE_F54C1.3 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | mes-3 | ||||||||
| DB_info | Database | AceView | gene | 1F571 | |||||
| WormQTL | gene | WBGene00003221 | |||||||
| WormFlux | gene | WBGene00003221 | |||||||
| NDB | locus_tag | CELE_F54C1.3 | |||||||
| NCBI | gene | 172123 | |||||||
| RefSeq | protein | NM_001026321.4 | |||||||
| NM_001374884.2 | |||||||||
| SwissProt | UniProtAcc | Q10665 | |||||||
| TREEFAM | TREEFAM_ID | TF344107 | |||||||
| TrEMBL | UniProtAcc | G8JY65 | |||||||
| UniProt_GCRP | UniProtAcc | Q10665 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mes | ||||||||
| Allele (69) | |||||||||
| Legacy_information | [C.elegansII] bn35 : grandchildless, progeny undergo normal embryogenesis but develop into agametic adults; few germ cells made. Normal P granule staining. XO germ line less affected. OA4: bn53 (stronger allele), bn21ts (100% sterile 25C, 2% 16C; T-shift suggests action in early embryo). Cloned: 3.1 kb transcript, encodes novel protein. In operon with dom-3. [Capowski et al. 1991; SS] | ||||||||
| Strain | WBStrain00034437 | ||||||||
| WBStrain00034439 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00021119 | ||||||||
| 00021120 | |||||||||
| 00056599 | |||||||||
| 00056600 | |||||||||
| 00056601 | |||||||||
| 00056602 | |||||||||
| 00056603 | |||||||||
| Contained_in_operon | CEOP1212 | ||||||||
| Ortholog (19) | |||||||||
| Structured_description | Concise_description | mes-3 encodes a novel protein with no discernible motifs; however, as a member of a Polycomb-like chromatin repressive complex with MES-2 and MES-6, MES-3 is required maternally for normal germline development and during larval development, for anteroposterior patterning; during germline development, the MES-2/MES-3/MES-6 complex is believed to be essential for maintaining repression of the X chromosome, and in transgenic animals, the complex is necessary for germline repression of repetitive transgenes; in axial patterning, the MES-2/MES-3/MES-6 complex is required in somatic tissues for maintaining homeotic gene repression, acting upstream of the Hox genes lin-39, mab-5, and egl-5, as well as the egl-5 target gene lin-32; MES-3 expression is detected in the nuclei of all cells during early embryogenesis, in some somatic cells and the germline precursors Z2 and Z3 during late embryogenesis and the L1 larval stage; in adults, MES-3 is expressed at highest levels in oocytes and germline nuclei in the proximal meiotic region with expression in the pachytene region negatively regulated by the RNA-binding protein GLD-1; MES-3 appears to be localized primarily to the nucleoplasm with some chromosomal association detectable during metaphase and early anaphase; in >24-cell-stage embryos, normal MES-3 levels and localization are dependent upon wild-type activity of MES-2 and MES-6 | Paper_evidence | WBPaper00001477 | |||||
| WBPaper00002342 | |||||||||
| WBPaper00005019 | |||||||||
| WBPaper00005301 | |||||||||
| WBPaper00005923 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 30 Jul 2004 00:00:00 | ||||||||
| Automated_description | Involved in regulation of gene expression. Located in nucleus. Part of PcG protein complex and nucleosome. Expressed in several structures, including Caa; Psub4; Z2; Z3; and germ line. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F54C1.3a | |||||||
| F54C1.3b | |||||||||
| Corresponding_CDS_history | F54C1.3b:wp114 | ||||||||
| F54C1.3b:wp273 | |||||||||
| Corresponding_transcript | F54C1.3a.1 | ||||||||
| F54C1.3a.2 | |||||||||
| F54C1.3b.1 | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Expr1736 | ||||||||
| Expr4057 | |||||||||
| Expr1024393 | |||||||||
| Expr1031521 | |||||||||
| Expr1152051 | |||||||||
| Expr2013531 | |||||||||
| Expr2031765 | |||||||||
| Drives_construct | WBCnstr00036179 | ||||||||
| Construct_product | WBCnstr00036179 | ||||||||
| Regulate_expr_cluster | WBPaper00064315:mes-3(bn199)_downregulated_EGCs | ||||||||
| WBPaper00064315:mes-3(bn199)_downregulated_PGCs | |||||||||
| WBPaper00064315:mes-3(bn199)_upregulated_EGCs | |||||||||
| WBPaper00064315:mes-3(bn199)_upregulated_PGCs | |||||||||
| Antibody | WBAntibody00000437 | ||||||||
| WBAntibody00000739 | |||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (101) | |||||||||
| Interaction (78) | |||||||||
| Map_info | Map | I | Position | -0.428825 | Error | 5.5e-05 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | B0231 | |||||||
| F54C1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Y55F5 | |||||||||
| Y72E2 | |||||||||
| Mapping_data | 2_point | 6041 | |||||||
| 6042 | |||||||||
| 6043 | |||||||||
| 6044 | |||||||||
| 6045 | |||||||||
| 6046 | |||||||||
| Multi_point (11) | |||||||||
| Pos_neg_data | 5997 | ||||||||
| 5998 | |||||||||
| 5999 | |||||||||
| 6000 | |||||||||
| 6001 | |||||||||
| 6002 | |||||||||
| 6003 | |||||||||
| 6004 | |||||||||
| 6005 | |||||||||
| 6025 | |||||||||
| Reference (89) | |||||||||
| Method | Gene |
