WormBase Tree Display for Gene: WBGene00003214
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| WBGene00003214 | SMap | S_parent | Sequence | C05D11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mel-32 | Person_evidence | WBPerson314 | |||||
| Sequence_name | C05D11.11 | ||||||||
| Molecular_name | C05D11.11a | ||||||||
| C05D11.11a.1 | |||||||||
| CE01130 | |||||||||
| C05D11.11b | |||||||||
| CE29661 | |||||||||
| C05D11.11a.2 | |||||||||
| C05D11.11a.3 | |||||||||
| C05D11.11b.1 | |||||||||
| Other_name | CELE_C05D11.11 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | mel-32 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mel | ||||||||
| Allele (60) | |||||||||
| Legacy_information | [Vatcher GP] homozygotes develope into adults that lay egg which do not hatch. | ||||||||
| [Schnabel H] other name: emb-25 NA18 | |||||||||
| Complementation_data | [Vatcher GP] complements let-713 (s2449), let-721(s2447), let-725(s2454), let-728(2573), let-747(s2456), let-756(s2613), let-767(s2464). | ||||||||
| Strain | WBStrain00001425 | ||||||||
| WBStrain00000962 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Ortholog (42) | |||||||||
| Structured_description | Concise_description | mel-32 encodes a serine hydroxymethyltransferase; by homology, MEL-32 is predicted to catalyze the biochemical reaction that converts serine to glycine and in the process transfers a methyl group to tetrahydrofolate and, thus, into the one-carbon pool used for a variety of cellular metabolic processes; in C. elegans MEL-32 activity is required maternally for embryonic development past the 100-cell stage. | Paper_evidence | WBPaper00003021 | |||||
| WBPaper00003363 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 10 Jan 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable several functions, including glycine hydroxymethyltransferase activity; ion binding activity; and nucleic acid binding activity. Involved in embryo development. Located in mitochondrion. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Is an ortholog of human SHMT1 (serine hydroxymethyltransferase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10850) | ||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10850) | ||||||
| Molecular_info | Corresponding_CDS | C05D11.11a | |||||||
| C05D11.11b | |||||||||
| Corresponding_transcript | C05D11.11a.1 | ||||||||
| C05D11.11a.2 | |||||||||
| C05D11.11a.3 | |||||||||
| C05D11.11b.1 | |||||||||
| Other_sequence (140) | |||||||||
| Associated_feature | WBsf651128 | ||||||||
| WBsf666995 | |||||||||
| WBsf666996 | |||||||||
| WBsf992765 | |||||||||
| WBsf992766 | |||||||||
| WBsf226823 | |||||||||
| WBsf226824 | |||||||||
| WBsf226825 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Chronogram490 | ||||||||
| Expr5167 | |||||||||
| Expr1024771 | |||||||||
| Expr1031517 | |||||||||
| Expr1143823 | |||||||||
| Expr2013519 | |||||||||
| Expr2031753 | |||||||||
| Drives_construct | WBCnstr00002309 | ||||||||
| WBCnstr00036183 | |||||||||
| Construct_product | WBCnstr00036183 | ||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (200) | |||||||||
| Interaction (121) | |||||||||
| Map_info | Map | III | Position | -1.27054 | Error | 0.001406 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDf127 | |||||||
| sDf125 | |||||||||
| sDp3 | |||||||||
| Positive_clone | C05D11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| pC05.11 | |||||||||
| Negative | Outside_rearr | sDf121 | |||||||
| Mapping_data | Pos_neg_data | 9286 | |||||||
| 9287 | |||||||||
| 9288 | |||||||||
| 9289 | |||||||||
| Reference (25) | |||||||||
| Remark | pC05.11 is a subclone of C05D11 containing only ORF 11. It partially rescues the Mel phenotype. | ||||||||
| Sequence connections updated by Darin Blasiar Jan, 2002 | |||||||||
| Method | Gene |
