WormBase Tree Display for Gene: WBGene00003171

WBGene00003171 SMap: S_parent: Sequence: ZK154
  Identity: Version: 1
    Name: CGC_name: mec-7 Person_evidence: WBPerson95
      Sequence_name: ZK154.3
      Molecular_name: ZK154.3
        ZK154.3.1
        CE15257
      Other_name: CELE_ZK154.3 Accession_evidence: NDB BX284606
      Public_name: mec-7
    DB_info: Database: AceView gene XI394
        WormQTL gene WBGene00003171
        WormFlux gene WBGene00003171
        NDB locus_tag CELE_ZK154.3
        Panther gene CAEEL|WormBase=WBGene00003171|UniProtKB=P12456
          family PTHR11588
        NCBI gene 181036
        RefSeq protein NM_076912.5
        SwissProt UniProtAcc P12456
        UniProt_GCRP UniProtAcc P12456
        OMIM gene 191130
            602660
            602662
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info (11)
  Disease_info: Experimental_model: DOID:14452 Homo sapiens Paper_evidence: WBPaper00002711
          Curator_confirmed: WBPerson324
          Date_last_updated: 24 Aug 2018 00:00:00
    Potential_model: DOID:0112242 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20778)
      DOID:0090136 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20778)
      DOID:0112240 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20771)
      DOID:0060798 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20774)
      DOID:0090041 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20774)
    Disease_relevance: C. elegans mec-4 and deg-1 genes encode proteins, called degenerins, that are similar to the subunits of the human amiloride-sensitive epithelial sodium-channels; death-inducing substitutions in the gain-of-function mutant deg-1, e1611 and u231, may hyperactivate the channels, resulting in increased or altered ion flow and/osmotic imbalance and consequent neuron death; similarities between the degenerin-induced deaths and the early pathology of of neurons in human dominant myotonias, excitotoxicity, and epilepsy suggest similar mechanisms; studies with the elegans mutations show that the abnormalities infolding of the plasma membrane whorls, cytoplasmic vacuoles, cell swelling, chromatin aggregates and nuclear invaginations; mitochondria and golgi are not dramatically affected until the final stages of cell death when organelles, and sometimes the cells lyse; pathology of degeneration is dependent on abnormal degenerin gene dosage. Homo sapiens Paper_evidence: WBPaper00002711
          Curator_confirmed: WBPerson324
          Date_last_updated: 13 Nov 2014 00:00:00
  Models_disease_asserted: WBDOannot00000609
  Molecular_info: Corresponding_CDS: ZK154.3
    Corresponding_transcript: ZK154.3.1
    Other_sequence (45)
    Associated_feature: WBsf654161
      WBsf654162
      WBsf977521
      WBsf977522
      WBsf977523
      WBsf977524
      WBsf1005948
      WBsf1023307
      WBsf237608
  Experimental_info: RNAi_result (18)
    Expr_pattern: Expr266
      Expr1504
      Expr1524
      Expr1577
      Expr11808
      Expr1015364
      Expr1031504
      Expr1162675
      Expr2013501
      Expr2031735
    Drives_construct (154)
    Construct_product: WBCnstr00000678
      WBCnstr00001034
      WBCnstr00015918
      WBCnstr00036199
    Antibody: WBAntibody00000087
      WBAntibody00001541
      WBAntibody00001774
      WBAntibody00001775
    Microarray_results (18)
    Expression_cluster (243)
    Interaction (229)
    WBProcess: WBbiopr:00000002
  Map_info: Map: X Position: -1.27615 Error: 0.00769
    Well_ordered
    Positive: Inside_rearr: raDf7
      Positive_clone: NW#B4
        ZK154 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 167
        672
        1828
      Multi_point (15)
      Pos_neg_data: 7293
        7294
        7295
        529
        3176
        9433
  Reference: WBPaper00000502
    WBPaper00000550
    WBPaper00000560
    WBPaper00000608
    WBPaper00000688
    WBPaper00000708
    WBPaper00000937
    WBPaper00001047
    WBPaper00001163
    WBPaper00001168
    WBPaper00001224
    WBPaper00001292
    WBPaper00001296
    WBPaper00001325
    WBPaper00001364
    WBPaper00001399
    WBPaper00001570
    WBPaper00001576
    WBPaper00001655
    WBPaper00001664
    WBPaper00001668
    WBPaper00001704
    WBPaper00001732
    WBPaper00001758
    WBPaper00001793
    WBPaper00001804
    WBPaper00001829
    WBPaper00001871
    WBPaper00001872
    WBPaper00001873
    WBPaper00001881
    WBPaper00001958
    WBPaper00002006
    WBPaper00002018
    WBPaper00002137
    WBPaper00002138
    WBPaper00002208
    WBPaper00002322
    WBPaper00002333
    WBPaper00002355
    WBPaper00002362
    WBPaper00002413
    WBPaper00002416
    WBPaper00002465
    WBPaper00002482
    WBPaper00002489
    WBPaper00002579
    WBPaper00002721
    WBPaper00002731
    WBPaper00002737
    WBPaper00002742
    WBPaper00002800
    WBPaper00002956
    WBPaper00002968
    WBPaper00003024
    WBPaper00003027
    WBPaper00003038
    WBPaper00003265
    WBPaper00003414
    WBPaper00003641
    WBPaper00003679
    WBPaper00003680
    WBPaper00004147
    WBPaper00004243
    WBPaper00004356
    WBPaper00005101
    WBPaper00005234
    WBPaper00005356
    WBPaper00005559
    WBPaper00005666
    WBPaper00005787
    WBPaper00005849
    WBPaper00005923
    WBPaper00006034
    WBPaper00006110
    WBPaper00006159
    WBPaper00006279
    WBPaper00006309
    WBPaper00006389
    WBPaper00006494
    WBPaper00010335
    WBPaper00010336
    WBPaper00010482
    WBPaper00010519
    WBPaper00010529
    WBPaper00010934
    WBPaper00010941
    WBPaper00010949
    WBPaper00010978
    WBPaper00011043
    WBPaper00011082
    WBPaper00011094
    WBPaper00011186
    WBPaper00011202
    WBPaper00011957
    WBPaper00013396
    WBPaper00013718
    WBPaper00013736
    WBPaper00013969
    WBPaper00013972
    WBPaper00014192
    WBPaper00014195
    WBPaper00014196
    WBPaper00014231
    WBPaper00014232
    WBPaper00014293
    WBPaper00014506
    WBPaper00014507
    WBPaper00014538
    WBPaper00014559
    WBPaper00014618
    WBPaper00014711
    WBPaper00014747
    WBPaper00014762
    WBPaper00014763
    WBPaper00014787
    WBPaper00014809
    WBPaper00014932
    WBPaper00014933
    WBPaper00014963
    WBPaper00014991
    WBPaper00015038
    WBPaper00015081
    WBPaper00015083
    WBPaper00015264
    WBPaper00015317
    WBPaper00015377
    WBPaper00015440
    WBPaper00015635
    WBPaper00015691
    WBPaper00015762
    WBPaper00016120
    WBPaper00016381
    WBPaper00016795
    WBPaper00017098
    WBPaper00017183
    WBPaper00017197
    WBPaper00017325
    WBPaper00017599
    WBPaper00017652
    WBPaper00017711
    WBPaper00017965
    WBPaper00017980
    WBPaper00018184
    WBPaper00018234
    WBPaper00018282
    WBPaper00018288
    WBPaper00018348
    WBPaper00018528
    WBPaper00018588
    WBPaper00018942
    WBPaper00019276
    WBPaper00020793
    WBPaper00020834
    WBPaper00020933
    WBPaper00020939
    WBPaper00021639
    WBPaper00021733
    WBPaper00021743
    WBPaper00021851
    WBPaper00021913
    WBPaper00022018
    WBPaper00022086
    WBPaper00022143
    WBPaper00022179
    WBPaper00022318
    WBPaper00022472
    WBPaper00022533
    WBPaper00022681
    WBPaper00022757
    WBPaper00022920
    WBPaper00023066
    WBPaper00023085
    WBPaper00023126
    WBPaper00023336
    WBPaper00023423
    WBPaper00023615
    WBPaper00023803
    WBPaper00023827
    WBPaper00023963
    WBPaper00024195
    WBPaper00024889
    WBPaper00025096
    WBPaper00025615
    WBPaper00025816
    WBPaper00025958
    WBPaper00026115
    WBPaper00026148
    WBPaper00027192
    WBPaper00027280
    WBPaper00027305
    WBPaper00027309
    WBPaper00028145
    WBPaper00028179
    WBPaper00029017
    WBPaper00030335
    WBPaper00030344
    WBPaper00030928
    WBPaper00031224
    WBPaper00032203
    WBPaper00032465
    WBPaper00033087
    WBPaper00033966
    WBPaper00033969
    WBPaper00034491
    WBPaper00034736
    WBPaper00034884
    WBPaper00035070
    WBPaper00037300
    WBPaper00038206
    WBPaper00038491
    WBPaper00040171
    WBPaper00041826
    WBPaper00042741
    WBPaper00043301
    WBPaper00043348
    WBPaper00043689
    WBPaper00044004
    WBPaper00044083
    WBPaper00044649
    WBPaper00045955
    WBPaper00047170
    WBPaper00049828
    WBPaper00050344
    WBPaper00050667
    WBPaper00050853
    WBPaper00052008
    WBPaper00052286
    WBPaper00052611
    WBPaper00052855
    WBPaper00054844
    WBPaper00055090
    WBPaper00059214
    WBPaper00059745
    WBPaper00060816
    WBPaper00061515
    WBPaper00061547
    WBPaper00061553
    WBPaper00063032
    WBPaper00063566
    WBPaper00064215
    WBPaper00064660
    WBPaper00065972
  Method: Gene