WormBase Tree Display for Gene: WBGene00003161
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| WBGene00003161 | SMap | S_parent | Sequence | Y69A2AR | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mdf-2 | Person_evidence | WBPerson533 | |||||
| Sequence_name | Y69A2AR.30 | ||||||||
| Molecular_name | Y69A2AR.30a | ||||||||
| Y69A2AR.30a.1 | |||||||||
| CE26559 | |||||||||
| Y69A2AR.30b | |||||||||
| CE30468 | |||||||||
| Y69A2AR.30c | |||||||||
| CE48529 | |||||||||
| Y69A2AR.30a.2 | |||||||||
| Y69A2AR.30b.1 | |||||||||
| Y69A2AR.30c.1 | |||||||||
| Other_name | mad-2 | Person_evidence | WBPerson1836 | ||||||
| Y69A2A_2326.a | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y69A2AR.30 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | mdf-2 | ||||||||
| DB_info | Database | AceView | gene | 4D402 | |||||
| WormQTL | gene | WBGene00003161 | |||||||
| WormFlux | gene | WBGene00003161 | |||||||
| NDB | locus_tag | CELE_Y69A2AR.30 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003161|UniProtKB=Q9NGT3 | |||||||
| family | PTHR11842 | ||||||||
| NCBI | gene | 177046 | |||||||
| RefSeq | protein | NM_001383055.1 | |||||||
| NM_001028392.8 | |||||||||
| NM_001307684.3 | |||||||||
| TREEFAM | TREEFAM_ID | TF101084 | |||||||
| TrEMBL | UniProtAcc | Q9NGT3 | |||||||
| U4PC21 | |||||||||
| Q8T870 | |||||||||
| UniProt_GCRP | UniProtAcc | Q9NGT3 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 19 Nov 2013 09:50:52 | WBPerson2970 | Name_change | Other_name | mad-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mdf | ||||||||
| Allele (107) | |||||||||
| Strain | WBStrain00000068 | ||||||||
| WBStrain00048564 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (33) | |||||||||
| Structured_description | Concise_description | mdf-2 encodes the C. elegans ortholog of the Mad2p spindle assembly checkpoint protein; mdf-2 activity is essential for regulation of the anaphase-promoting complex (APC) during oocyte meiosis I as well as for normal brood size, growth rates, and embryonic, larval, and vulval development; in addition, mdf-2 is essential for mitotic spindle checkpoint activity in response to anoxia, in which microscopically visible movement ceases and cell cycle progression reversibly arrests; by genetic analyses and comparison to studies in budding yeast, MDF-2 likely negatively regulates APC activity by inhibiting the activity of the FZY-1/CDC20p APC co-activator. | Paper_evidence | WBPaper00006169 | |||||
| WBPaper00028738 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Dec 2007 00:00:00 | ||||||||
| Automated_description | Involved in embryo development; mitotic spindle assembly checkpoint signaling; and response to anoxia. Located in kinetochore; microtubule cytoskeleton; and nucleus. Expressed in germ line. Is an ortholog of human MAD2L1 (mitotic arrest deficient 2 like 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y69A2AR.30a | |||||||
| Y69A2AR.30b | |||||||||
| Y69A2AR.30c | |||||||||
| Corresponding_transcript | Y69A2AR.30a.1 | ||||||||
| Y69A2AR.30a.2 | |||||||||
| Y69A2AR.30b.1 | |||||||||
| Y69A2AR.30c.1 | |||||||||
| Other_sequence (35) | |||||||||
| Associated_feature (16) | |||||||||
| Experimental_info | RNAi_result (25) | ||||||||
| Expr_pattern | Expr1095 | ||||||||
| Expr8641 | |||||||||
| Expr1026769 | |||||||||
| Expr1031496 | |||||||||
| Expr1161467 | |||||||||
| Expr2013464 | |||||||||
| Expr2031698 | |||||||||
| Drives_construct | WBCnstr00009405 | ||||||||
| WBCnstr00018337 | |||||||||
| WBCnstr00036208 | |||||||||
| Construct_product | WBCnstr00000910 | ||||||||
| WBCnstr00036208 | |||||||||
| Antibody | WBAntibody00000258 | ||||||||
| WBAntibody00002935 | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (176) | |||||||||
| Interaction (155) | |||||||||
| Map_info | Map | IV | Position | -6.81598 | Error | 0.022219 | |||
| Positive | Positive_clone | Y69A2AR | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5671 | |||||||
| 5262 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (49) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| This gene has been named mad (Mitotic Arrest Deficient) in other species and so mad-2 has been added as an other_name. | |||||||||
| Method | Gene |
