WormBase Tree Display for Gene: WBGene00003155

WBGene00003155 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C25D7
  Identity: Version: 1
    Name: CGC_name: mcm-3 Person_evidence: WBPerson1160
      Sequence_name: C25D7.6
      Molecular_name: C25D7.6
        C25D7.6.1
        CE08392
      Other_name: CELE_C25D7.6 Accession_evidence: NDB BX284605
      Public_name: mcm-3
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mcm
    Allele (50)
    Strain: WBStrain00047480
    RNASeq_FPKM (74)
    GO_annotation (29)
    Ortholog (39)
    Paralog: WBGene00003154 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003158 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003156 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003157 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003159 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: mcm-3 encodes a member of the MCM2/3/5 family with similarity to human DNA replication licensing factor, MCM3, and affects embryonic viability. Paper_evidence: WBPaper00005599
          Curator_confirmed: WBPerson48
          Date_last_updated: 09 Aug 2004 00:00:00
      Automated_description: Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Predicted to be involved in DNA strand elongation involved in DNA replication; double-strand break repair via break-induced replication; and mitotic DNA replication initiation. Located in condensed chromosome and pronucleus. Expressed in ciliated neurons. Is an ortholog of human MCM3 (minichromosome maintenance complex component 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C25D7.6
    Corresponding_transcript: C25D7.6.1
    Other_sequence (33)
    Associated_feature: WBsf653428
      WBsf653429
      WBsf669765
      WBsf669766
      WBsf977368
      WBsf977369
      WBsf977370
      WBsf235021
  Experimental_info: RNAi_result (16)
    Expr_pattern: Expr9923
      Expr13708
      Expr15984
      Expr1026374
      Expr1031490
      Expr1145206
      Expr2013450
      Expr2031684
    Drives_construct: WBCnstr00036214
      WBCnstr00042634
    Construct_product: WBCnstr00009677
      WBCnstr00036214
      WBCnstr00042634
    Antibody: WBAntibody00002984
    Microarray_results (20)
    Expression_cluster: WBPaper00028451:Oogenic_protein
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032425:up_in_lin-35
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038168:lin-35_upregulated
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_Day5
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00044760:germline_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045050:csr-1(hypomorph)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045618:puf-8_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046421:cdc-48.2(tm659)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050193:cec-4(ok3124)_downregulated_L1
      WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00051265:F1_morc-1(tm6048)_downregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051461:pig-1(gm344)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00054191:H3.3(null)_L1_upregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056284:ints-5(RNAi)_downregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00059174:MEG-3_interacting
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059728:5ug_cholesterol_downregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:ABarpaaa_lineage
      WBPaper00061340:ADA_ADE_grandparent
      WBPaper00061340:Ciliated_amphid_neuron
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:PLM_ALN_great_grandparent
      WBPaper00061527:F54E7.8-orc-5_6376
      WBPaper00061527:pch-2-B0393.3
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061699:daf-18(ok480)_upregulated
      WBPaper00061753:csr-1(tor159)_downregulated_25C
      WBPaper00062056:efl-1(se1)_upregulated
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062056:lin-36(we36)_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062456:doxycycline_downregulated_N2_protein
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064502:spe-44(fx110)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065149:lin-52(n771)_upregulated
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_6_2
      cgc4489_group_2
      WBPaper00025032:cluster_13
      WBPaper00025032:cluster_87
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_A
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031060:2-deoxy-D-glucose_downregulated
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00034739:N2lessDR1350
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_F
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040426:CYD-1_CDK-4_upregulated
      WBPaper00040426:CYE-1_CDK-2AF_upregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040963:TA300_down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_3h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042258:DA1877_downregulated_GravidAdult
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00055435:AuNPs_downregulated
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (203)
  Map_info: Map: V Position: 7.23535 Error: 0.008915
    Positive: Positive_clone: C25D7 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (12)
  Remark: Sequence connection from [Kim SK]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene