WormBase Tree Display for Gene: WBGene00003144
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| WBGene00003144 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | max-2 | Paper_evidence | WBPaper00005251 | |||||
| Sequence_name | Y38F1A.10 | ||||||||
| Molecular_name (18) | |||||||||
| Other_name | pak-8 | ||||||||
| CELE_Y38F1A.10 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | max-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 04 Dec 2006 12:09:25 | WBPerson1847 | Event | Acquires_merge | WBGene00012611 | ||||
| Name_change | Other_name | pak-8 | |||||||
| Acquires_merge | WBGene00012611 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | max | ||||||||
| Allele (334) | |||||||||
| Strain | WBStrain00036615 | ||||||||
| WBStrain00037251 | |||||||||
| WBStrain00008431 | |||||||||
| WBStrain00008432 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (47) | |||||||||
| Ortholog (34) | |||||||||
| Paralog (27) | |||||||||
| Structured_description | Concise_description | max-2 encodes, by alternative splicing, at least two isoforms of aputative p21-activated kinase that is required (redundantly with itsparalog, PAK-1) for normal axonal guidance of motoneurons, P cellmigration, and locomotion, with max-2(cy2);pak-1(ok448) double mutantsphenotypically resembling unc-73 or ced-10;mig-2 mutants; max-2 isexpressed ubiquitously in early embryos, then localizes to the anteriorembryo and is expressed in pharynx and head neurons; postembryonically,max-2 seems to be expressed in body wall touch receptors (ALM, PLM, PVD,and PLM), but can rescue max-2 mutations when transgenically expressedin ventral cord motoneurons; by themselves, max-2 mutations have onlymild axonal guidance phenotypes and only subtle defects in movement;MAX-2 is required for normal sensitivity to aldicarb; max-2 mutationssuppress UNC-5 overexpression phenotypes, and are dominantly enhanced byunc-5 or unc-6 mutations, indicating that MAX-2 functions downstream ofthe netrin receptor UNC-5. | Paper_evidence | WBPaper00005251 | |||||
| WBPaper00026667 | |||||||||
| WBPaper00028729 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 31 Jan 2007 00:00:00 | ||||||||
| Automated_description | Enables mitogen-activated protein kinase kinase kinase binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including gonad morphogenesis; inductive cell migration; and signal transduction. Predicted to be located in cytoplasm. Expressed in neurons; pharynx; and ventral nerve cord. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y38F1A.10a | |||||||
| Y38F1A.10b | |||||||||
| Y38F1A.10c | |||||||||
| Y38F1A.10d | |||||||||
| Y38F1A.10e | |||||||||
| Y38F1A.10f | |||||||||
| Corresponding_CDS_history | Y38F1A.10:wp109 | ||||||||
| Y38F1A.10:wp165 | |||||||||
| Corresponding_transcript | Y38F1A.10a.1 | ||||||||
| Y38F1A.10b.1 | |||||||||
| Y38F1A.10c.1 | |||||||||
| Y38F1A.10d.1 | |||||||||
| Y38F1A.10e.1 | |||||||||
| Y38F1A.10f.1 | |||||||||
| Other_sequence (44) | |||||||||
| Associated_feature (24) | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr3622 | ||||||||
| Expr4345 | |||||||||
| Expr1017414 | |||||||||
| Expr1031483 | |||||||||
| Expr1159555 | |||||||||
| Expr2013428 | |||||||||
| Expr2031662 | |||||||||
| Drives_construct | WBCnstr00011934 | ||||||||
| WBCnstr00020139 | |||||||||
| Construct_product | WBCnstr00011547 | ||||||||
| WBCnstr00020139 | |||||||||
| WBCnstr00020140 | |||||||||
| Microarray_results (37) | |||||||||
| Expression_cluster (106) | |||||||||
| Interaction (15) | |||||||||
| Map_info | Map | II | Position | 13.6601 | Error | 0.086737 | |||
| Positive | Positive_clone | Y38F1A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (23) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
