WormBase Tree Display for Gene: WBGene00003133
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| WBGene00003133 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | apc-1 | Person_evidence | WBPerson29989 | |||||
| Sequence_name | W10C6.1 | ||||||||
| Molecular_name | W10C6.1 | ||||||||
| W10C6.1.1 | |||||||||
| CE54528 | |||||||||
| Other_name | pod-3 | ||||||||
| evl-22 | |||||||||
| mat-2 | Person_evidence | WBPerson205 | |||||||
| apc-17 | Person_evidence | WBPerson1816 | |||||||
| WBPerson205 | |||||||||
| CELE_W10C6.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | apc-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 03 Jan 2022 22:40:49 | WBPerson1983 | Event | Acquires_merge | WBGene00007501 | ||||
| Name_change | CGC_name | apc-1 | |||||||
| Other_name | mat-2 | ||||||||
| Acquires_merge | WBGene00007501 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | apc | ||||||||
| Allele (171) | |||||||||
| Legacy_information | [Shakes DC] Mutation is defective in metaphase to anaphase transition. | ||||||||
| [C.elegansII] ar104 : everted vulva, sterile, no L4 vulval invagination; no uterine cavity; no sperm or oocytes. NA1. [Seydoux et al., 1993] | |||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Contained_in_operon | CEOP2516 | ||||||||
| Ortholog (47) | |||||||||
| Structured_description | Concise_description | mat-2 encodes a subunit of the anaphase-promoting complex or cyclosome (APCC) which is a multi-subunit E3 ubiquitin ligase that targets proteins for degradation during the metaphase-to-anaphase transition of the cell cycle; mat-2 is required for chromosome segregation during meiosis I and is involved in polarity specification of the anterior/posterior axis in the developing embryo. | Paper_evidence | WBPaper00004484 | |||||
| WBPaper00005095 | |||||||||
| WBPaper00005096 | |||||||||
| WBPaper00005823 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable molecular adaptor activity. Involved in several processes, including establishment of meiotic spindle localization; metaphase/anaphase transition of cell cycle; and polarity specification of anterior/posterior axis. Part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Is an ortholog of human ANAPC1 (anaphase promoting complex subunit 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2732 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19988) | ||||
| Molecular_info | Corresponding_CDS | W10C6.1 | |||||||
| Corresponding_CDS_history | W10C6.1:wp197 | ||||||||
| W10C6.1:wp282 | |||||||||
| Corresponding_transcript | W10C6.1.1 | ||||||||
| Other_sequence | Oden_isotig19802 | ||||||||
| CBC06189_1 | |||||||||
| EX553911.1 | |||||||||
| MP00954 | |||||||||
| Acan_isotig09044 | |||||||||
| Tcol_isotig14030 | |||||||||
| JI236511.1 | |||||||||
| ACC09101_1 | |||||||||
| EX553361.1 | |||||||||
| Dviv_isotig23131 | |||||||||
| Associated_feature | WBsf658222 | ||||||||
| WBsf989629 | |||||||||
| WBsf989630 | |||||||||
| WBsf222095 | |||||||||
| WBsf222096 | |||||||||
| WBsf222097 | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Expr1013593 | ||||||||
| Expr1026786 | |||||||||
| Expr1031478 | |||||||||
| Expr1033226 | |||||||||
| Expr1144328 | |||||||||
| Expr1158612 | |||||||||
| Expr2009353 | |||||||||
| Expr2013391 | |||||||||
| Expr2027589 | |||||||||
| Expr2031623 | |||||||||
| Microarray_results (37) | |||||||||
| Expression_cluster (169) | |||||||||
| Interaction (120) | |||||||||
| Map_info | Map | II | Position | 3.31638 | Error | 0.004741 | |||
| Positive | Positive_clone | W10C6 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 3923 | |||||||
| 3466 | |||||||||
| 4551 | |||||||||
| 4599 | |||||||||
| Pos_neg_data | 10567 | ||||||||
| 10568 | |||||||||
| 10569 | |||||||||
| 10570 | |||||||||
| Reference (38) | |||||||||
| Method | Gene |
